Journal of Medicinal and Pharmaceutical Chemistry Research

AbstractDiabetes is characterized by insulin deficiency and insulin resistance. The Centaurea genus, has been used in traditional medicine. Between the purified sesquiterpene lactones of C. rhizantha, deacylcynaropicrin 8-O-[3′-hydroxy-2′-methylpropionate] demonstrated the cyctotoxic effect on HepG2 (IC50:25.05 µg/ml). All of the tested compounds could increase gluco…

The internal iliac artery (IIA) and superior gluteal artery (SGA) are major vascular structures of the pelvis and gluteal region. Anatomical variations of these vessels may influence pelvic surgery, reconstructive procedures, and endovascular interventions. However, detailed anatomical data in the Vietnamese population remain limited. This study aims to describe the origin, branching patterns, mo…

Cancer pathogenesis is driven by genetic mutations and epigenetic alterations that disrupt core cellular processes, including cell cycle regulation, apoptosis, and differentiation. Deciphering these mechanisms is critical for the development of targeted therapies. This study utilizes Density Functional Theory (DFT) simulations to assess the efficacy of pristine and doped (M = Fe, Zn, N) carbon na…

Co-crystallization offered a promising strategy to improve the physicochemical and pharmacological properties of active pharmaceutical ingredients (APIs). Metformin, a first-line antidiabetic, suffers from gastrointestinal issues and limited bioavailability, while hesperetin, a flavonoid with antioxidant potential, exhibits poor water solubility. Designing metformin and hesperetin co-crystals cou…

Diabetes mellitus (DM) has emerged as an international health issue due to its rapidly rising incidence. Uncontrolled diabetes leads to hyperglycemia, or elevated blood glucose levels, which can damage several body systems, including blood vessels and neurons. This study aims to predict the potential of 10 compounds, including chalcones, quinones, and alkaloids found in the Myristica, against ins…

Healthcare-associated infections are caused by pathogens capable of developing resistance to multiple antimicrobials. The objective was to evaluate the phytochemical profile, antibacterial potential on drug-resistant microorganisms, and toxicity in Artemia salina of Sambucus peruviana extracts. This experimental study evaluated strains of Escherichia coli and Klebsiella pneumoniae ESBL, carbapene…

Abstract. Cerebrovascular disease (CVD) is a major medical problem, significantly impacting patients' quality of life and social adaptation [1]. Asthenia and affective disorders are the most common consequences of both acute cerebrovascular diseases, such as stroke and transient ischemic attacks, and chronic ones [2]. Purpose: To assess and compare the level of asthenia, the severity of…

The article explored the effect of the moderating impact of customer satisfaction on technological readiness of omnichannel banking on the performance of pharmaceutical retailing in Odisha amidst the changing digital environment. Specifically, the study aimed at evaluating the influence of technological readiness on the transaction efficiency, payment processing, inventory coordination, accessibi…

A comprehensive computational investigation was performed on the adsorption behaviour of cytarabine anti-cancer drug on the surface of pristine and Fe-decorated (5,5) armchair single-walled carbon nanotube by the density functional theory. The structural parameters, adsorption energies, dipole moments, density of states, the highest occupied molecular orbitals, the lowest unoccupied molecular orb…

Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment for active moderate-to-severe thyroid eye disease (TED). However, systemic corticosteroids may affect blood pressure, glucose metabolism, and liver enzymes, requiring clinical monitoring. To evaluate changes in blood pressure, random blood glucose, and serum transaminase levels in TED patients receiving IVMP pulse the…

Myasthenia gravis (MG) is an autoimmune disease characterized by a disorder of neuromuscular transmission.Purpose. The aim of the study was to investigate the clinical and epidemiological features of myasthenia in the Stavropol Territory (ST).Material and methods. The study was based on an analysis of the medical records of 85 patients diagnosed with myasthenia gravis. The diagnosis was verified …

In this study, the impact of the omnichannel banking system on the efficiency and accessibility of pharmaceutical retail industry in the state of Odisha in light of digitalization was explored. The impact of integrated channels of banking on transaction management, inventory management, supplier payments, and customer relations in pharmaceutical retail businesses was studied. In this research, pr…

The present study was conducted to investigate the effects of decaffeinated and caffeinated coffee consumption, in a combination with atorvastatin, on selected lipidemic profle parametes, as well as liver and kidney function biomarkers in hyperlipidemia-induced rats. Major coffee constituents, including caffeine and chlorogenic acid, were extracted and quantified using HPLC-DAD. A total of 54 fe…

Tyrosine kinase inhibitors (TKIs) have demonstrated favorable responses in lung adenocarcinoma patients with EGFR (Epidermal Growth Factor Receptor) mutations, leading to improved 5-year progression-free survival rates. However, identifying EGFR mutation status typically requires molecular testing through biopsy, which is invasive and may yield insufficient tissue samples. For decades, computed t…

Background: Healthcare systems worldwide are undergoing rapid digital transformation driven by emerging technologies such as the Internet of Things (IoT), artificial intelligence (AI), machine learning (ML), blockchain, edge computing, digital twins, and big data analytics. These innovations are reshaping clinical workflows, patient engagement, healthcare administration, and medical research, res…

Psoriasis is a type of epidermal, hereditary, immune-mediated inflammatory disorder that is often connected to metabolic comorbidities especially in the elderly. Methotrexate is administered once weekly in moderate or severe psoriasis, in addition to anti-glucose effects, Metformin has anti-inflammatory and metabolic effects that can be beneficial in improving the results of treating psoriasis. T…

High Grade Non-Hodgkin Lymphoma (NHL) is a malignancy with limited therapeutic alternatives and poor prognosis. Zinc is a known micronutrient that is involved in immune response expression. It was hypothesized that zinc therapy can modulate the immune system following chemotherapy in patients with high grade NHL. This study aimed to explore the effect of zinc supplementation on serum zinc levels …

To evaluate the therapeutic potential of Emblica officinalis seed extract on ovalbumin-induced allergic asthma in Swiss Albino mice. The hydroalcoholic extract was prepared with seeds of Emblica officinalis (HAE). The seed extract was tested against ovalbumin (OVA)-induced allergic asthma in Swiss albino mice. The test medicines are given orally before being challenged with OVA aerosol 2.5% w/v. …

Pancreaticoduodenectomy (PD) is the only potentially curative treatment for periampullary cancer, but it carries high postoperative morbidity and mortality. Enhanced Recovery After Surgery (ERAS) protocols aim to standardize perioperative care and accelerate recovery. This study evaluated the association of ERAS implementation with postoperative outcomes after PD at Dr. Kariadi General Hospital. …