Journal of Medicinal and Pharmaceutical Chemistry Research

Tyrosine kinase inhibitors (TKIs) have demonstrated favorable responses in lung adenocarcinoma patients with EGFR (Epidermal Growth Factor Receptor) mutations, leading to improved 5-year progression-free survival rates. However, identifying EGFR mutation status typically requires molecular testing through biopsy, which is invasive and may yield insufficient tissue samples. For decades, computed t…

Background: Healthcare systems worldwide are undergoing rapid digital transformation driven by emerging technologies such as the Internet of Things (IoT), artificial intelligence (AI), machine learning (ML), blockchain, edge computing, digital twins, and big data analytics. These innovations are reshaping clinical workflows, patient engagement, healthcare administration, and medical research, res…

Psoriasis is a type of epidermal, hereditary, immune-mediated inflammatory disorder that is often connected to metabolic comorbidities especially in the elderly. Methotrexate is administered once weekly in moderate or severe psoriasis, in addition to anti-glucose effects, Metformin has anti-inflammatory and metabolic effects that can be beneficial in improving the results of treating psoriasis. T…

High Grade Non-Hodgkin Lymphoma (NHL) is a malignancy with limited therapeutic alternatives and poor prognosis. Zinc is a known micronutrient that is involved in immune response expression. It was hypothesized that zinc therapy can modulate the immune system following chemotherapy in patients with high grade NHL. This study aimed to explore the effect of zinc supplementation on serum zinc levels …

To evaluate the therapeutic potential of Emblica officinalis seed extract on ovalbumin-induced allergic asthma in Swiss Albino mice. The hydroalcoholic extract was prepared with seeds of Emblica officinalis (HAE). The seed extract was tested against ovalbumin (OVA)-induced allergic asthma in Swiss albino mice. The test medicines are given orally before being challenged with OVA aerosol 2.5% w/v. …

Pancreaticoduodenectomy (PD) is the only potentially curative treatment for periampullary cancer, but it carries high postoperative morbidity and mortality. Enhanced Recovery After Surgery (ERAS) protocols aim to standardize perioperative care and accelerate recovery. This study evaluated the association of ERAS implementation with postoperative outcomes after PD at Dr. Kariadi General Hospital. …

The primary objective of this study is to evaluate the effectiveness of blowing soap bubbles in lowering pain and promoting comfort among postoperative children. The study employed a quasi-experimental design and used purposive sampling with randomization, with established inclusion and exclusion criteria. The sample comprised 60 postoperative children with minor surgical procedures and were hosp…

Food-specific IgG antibodies are increasingly investigated for their potential role in food intolerance, though their clinical relevance remains debated. Unlike IgE-mediated reactions, IgG-mediated responses are delayed and may be associated with gastrointestinal and systemic symptoms. Most prior studies have focused on Western populations, with limited evidence from Asian cohorts. This study aim…

To critically examine the transition from a symptom-centric model to a social empowerment framework in perinatal mental health care by exploring the lived experiences, key facilitators, and structural barriers identified by childbearing individuals. A qualitative, hermeneutic-phenomenological study utilizing in-depth, semi-structured interviews. Urban public-sector maternity clinics serving a soc…

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that is associated with severe cardiovascular and renal complications. Sodium–glucose co-transporter 2 (SGLT2) inhibitors have emerged as an effective therapeutic class for managing hyperglycemia and its associated comorbidities. In this study, an integrated ligand- and structure-based virtual screening approach was employed to…

Zika virus (ZIKV) remains a significant global health concern due to its association with severe neurological complications and the lack of approved antiviral therapies. The viral non-structural protein 5 (NS5), particularly its RNA-dependent RNA polymerase (RdRp) domain, is essential for viral replication and immune evasion and lacks a human homolog, making it an attractive antiviral target. Usi…