medicine

“Longevity” — a buzzy catchall for the quest for a longer life — is having a moment. Tech titans like Peter Thiel, Mark Zuckerberg, and Jeff Bezos are spending billions to fund research into how to slow aging. Celebrities like Gwyneth Paltrow and Hailey Bieber are touting peptide use. And the world’s most powerful authoritarian […]

BackgroundAs a first-line treatment for acute ischemic stroke (AIS), tenecteplase (TNK) can cause adverse effects, such as depression, in AIS patients.ObjectiveThis study aims to elucidate the TNK target-related pathogenic mechanisms underlying major depressive disorder (MDD) in AIS patients.MethodsBy analyzing six public peripheral blood bulk datasets from AIS and MDD patients using integrative …

Fluorodeoxyglucose (FDG) PET to evaluate patients with epilepsy is one of the most common applications for simultaneous PET/MRI, given the need to image both brain structure and metabolism but is suboptimal due to the radiation dose in this young population. Little work has been done synthesizing diagnostic quality PET images from MRI data or MRI data with ultralow-dose PET using advanced generat…

This Collection highlights recent progress in genome editing technology developments. These developments offer exciting opportunities to reshape our approach to understanding biology, driving progress in various fields such as gene therapy, medicine, and agriculture.

Scientific Reports, Published online: 16 June 2026; doi:10.1038/s41598-026-57367-8 Correction: Anticarcinogenic effects of miR-199a-loaded gold nanoparticles on hepatocellular carcinoma: in vitro study

It is hoped that recent legal cases will encourage psychiatrists to think twice before administering ECT and ensure that patients and families are given better information about the risks.

At least eight states have banned the plant-derived product as more people use it and some claim it’s addictive In 2024, Maizie Hepner, 24, started visiting a bar in Dubuque, Iowa that did not serve alcohol and instead offered beverages containing kava and kratom, psychoactive substances derived from plants. The drinks were marketed as “herbal tea mocktails”. Hepner, who works as a server and bar…

A new study finds that a supervised Nordic walking program can significantly reduce moderate to severe depression symptoms in just five weeks. The aerobic workout proved especially beneficial for participants who started with the most severe symptoms.

FutureNeuro, the Research Ireland Centre for Translational Brain Science hosted by RCSI University of Medicine and Health Sciences, has launched a new proteomics study aimed at identifying biological markers that could support more personalized treatment for people experiencing first‑episode psychosis.

A human brain network associated with survival in children with diffuse midline glioma (DMG), the deadliest childhood brain cancer, has been identified by UCL clinician-scientists, raising the possibility of entirely new treatment approaches. The researchers found that DMG tumors seem to exploit the brain’s existing neural circuitry to drive tumor growth and progression. Tumors that […]

Nature Medicine, Published online: 16 June 2026; doi:10.1038/d41591-026-00031-5 Engineered heart muscle allografts derived from induced pluripotent stem cells show promising early outcomes in patients with treatment-refractory advanced heart failure with reduced left ventricular ejection fraction, in support of further clinical investigation.

One of the largest real-world studies of people taking GLP-1 medications found women, those without pre-existing conditions such as type 2 diabetes and high blood pressure, and behavioral factors such as previously setting a weight goal were the best predictors of total weight loss, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.

Acta Pharmacologica Sinica, Published online: 16 June 2026; doi:10.1038/s41401-026-01849-y DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice

Medical societies endorse ACOG’s schedule, saying maternal vaccines are ‘key element’ of protection The leading professional organization for obstetricians and gynecologists in the US has launched its first maternal vaccination schedule and diverged for the first time from federal recommendations. The American College of Obstetricians and Gynecologists (ACOG) has long recommended giving the shots…

The U.S. Food and Drug Administration’s (FDA) renewed focus on drug repurposing is bringing fresh attention to a regulatory pathway that has quietly shaped drug development for decades: 505(b)(2). Starting out as a critical mechanism bridging the gap between traditional 505(b)(1) new drug applications and abbreviated new drug applications (ANDAs), its adoption expanded over time as sponsors recog…

Scientists have modeled the potential size of this current outbreak, which some experts think could become one of the worst Ebola epidemics on record

BackgroundThrombocytopenia is a common adverse reaction of linezolid, often leading to severe complications. It is challenging to externally validate directly apply developed in other countries. We aim to develop and validate a risk prediction model of linezolid-associated thrombocytopenia (LAT) tailored to Vietnamese setting and to construct a simplified risk score calculation to support clinica…

The escalating global prevalence of carbapenem-resistant Gram-negative bacteria has significantly constrained therapeutic options, leading to the revived use of polymyxins. However, this resurgence has been paralleled by an increase in reports of associated adverse effects. No case of drug fever induced by polymyxin B (PMB) has been reported in the literature to date. We report the first case of …

BackgroundMetabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic lipid accumulation, with limited safe and effective therapeutic options currently available. Previous studies have demonstrated that mangiferin (MAN) alleviates nonalcoholic fatty liver disease via modulation of the AMPK and NLRP3 signaling pathways. However, there are no reports to date investigating…