medicine

Detecting melanoma before it becomes visible is a major challenge in dermatology. Now, with researchers from Université de Montréal, scientists at Université du Québec's Institut national de la recherche scientifique (INRS) have developed a promising solution.

ObjectiveTo examine whether psychological resilience and psychological distress serially mediate the association between fear of disease progression and quality of life (QoL) in patients with chronic heart failure (CHF).MethodsThis cross-sectional study enrolled 212 patients with CHF admitted between June 2023 and June 2025. Assessment tools included a demographic questionnaire, the Fear of Progr…

IntroductionFacial feedback mechanisms can modulate affective states. A series of clinical trials have shown that injection of botulinum toxin A can improve the symptoms of depression, probably via the disruption of proprioceptive afferences from the glabellar region to the brain. In extension of this research, we developed a physiotherapeutic program for the facial rehabilitation of wellbeing in…

IntroductionDirect-acting antivirals (DAAs) have dramatically changed hepatitis C virus (HCV) treatment, by achieving high virological cure rates and a reduced percentage of adverse events compared with previous treatments. Despite this, long-term psychiatric and quality-of-life (QoL) outcomes after viral eradication remain insufficiently understood. This study provides an 80-month follow-up of a…

BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is an FDA-approved, non-invasive treatment for Major Depressive Disorder (MDD). rTMS has a favorable safety profile, however, headaches are a common side effect. It is unclear which patients may be at greatest risk for headache, which device parameters might be associated with headache, and whether occurrence of headaches during rTMS a…

BackgroundBreast cancer patients are at an increased risk of insomnia, which can lead to emotional disorders, reduced quality of life, and potentially higher cancer mortality. Auricular acupuncture (AA) offers a feasible treatment option due to its short procedure time, low technical complexity, and relative safety. However, while preliminary studies suggest potential benefits of AA for treating …

BackgroundCadmium(Cd) exposure is associated with anxiety, but mechanism-informed multi-target interventions are limited.MethodsWe profiled plasma proteomes by LC-MS/MS in a propensity-score-matched Cd-exposed cohort (25 anxious vs 25 non-anxious). Anxiety-associated proteins were used as seeds for reverse screening in TCMIP v2.0, followed by network integration, molecular docking, 100ns molecula…

A nationwide survey reveals that eating meals at irregular times is tied to a higher likelihood of depression. Dietary diversity can cushion this effect, while regularly skipping breakfast amplifies the connection between sporadic eating schedules and low mood.

Health workers responding to a rapidly spreading outbreak of a rare type of Ebola in eastern Congo face two kinds of threats.

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01806-9 Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer

Director general of World Health Organization urges neighbouring countries to take immediate action The World Health Organization has warned that the Ebola outbreak is outpacing response efforts and countries neighbouring the Democratic Republic of Congo (DRC) are at high risk from the disease. “We are urgently scaling up operations, but at the moment the epidemic is outpacing us,” said the WHO’s…

Radiochemistry and Radiopharmacy Solutions, more commonly known as RadCore, has launched an exciting new era of scientific possibility at Michigan State University, with several clinical trials underway fueled by the new central facility – the MSU Radiopharmacy. RadCore’s mission is to manufacture and transform raw radioisotopes into high-quality imaging and therapeutic agents for research studie…

Obesity may worsen Alzheimer’s disease through fat molecules that send harmful signals to the brain, but targeting those molecules could offer a new path for intervention. Alzheimer’s disease is often viewed as a disorder that begins and ends in the brain. But growing evidence suggests the disease may also be shaped by what happens throughout [...]

A new type of cell therapy shows promise as the first treatment for advanced liver disease, following results from a clinical trial.

People often ask me for my favorite statistic. My answer changes, depending on what I’m obsessed with at any given moment. But my least favorite has been the same for years: five million children die every year. Not just because of the pain and loss that it represents, but especially because most of these deaths are avoidable. But to reduce mortality, we need to understand what children are dying…

Researchers reviewing decades of evidence conclude that alcohol plays a major role in disease and injury, affecting everything from the immune system to the brain and heart. A major new review published in Addiction paints a sobering picture of alcohol’s impact on health, linking drinking to dozens of diseases, infections, and injuries that affect nearly [...]

Doctors Still Struggle to Diagnose a Condition That Kills More Americans Than Stroke https://www.theatlantic.com/health/...telligence-diagnosing-early-detection/671755/ Each year in the United States, sepsis kills more than a quarter million ... Read more

Scientists at UC Riverside uncovered evidence that compounds beyond THC may influence how the body regulates metabolism and insulin signaling. A preclinical study from the University of California, Riverside offers new insight into a puzzling pattern that scientists have noticed for years: people who use cannabis chronically often have lower body weight and a lower [...]

I was primed to sweat my way through a high-stakes procedure. But once the patient was sedated, a welcome warmth entered the room Read more in this series here I’ve had quite a few surgical procedures over the years but one always sticks in my mind. The 7am arrival to hospital, the injustice of being deprived a morning coffee in the name of “fasting”, the apprehension as I lay on the operating ta…

Two other small British children who stayed at same hotel fell critically ill from same condition months earlier The travel company Tui is under scrutiny over its safety protocols after a British baby girl died from a gastric illness following a stay at an Egyptian hotel – the same resort where two other children were left critically ill from the same condition months earlier. Ariella Mann, one, …