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Depression may shape how much children pay attention to emotional expressions - sad or happy faces - and those changes appear to depend on whether the child has a family history of depression, according to a first-of-its-kind study from Binghamton University, State University of New York.

New research suggests that a common second-line blood pressure treatment may not be as kidney-friendly as previously assumed for some people with diabetic kidney disease. Blood pressure control is one of the most important ways to slow kidney damage in people with type 2 diabetes. But new research suggests that one of the most commonly [...]
Activists say blanket ban could prevent teenagers from discovering peers and role models with similar conditions Disability activists have said banning under-16s from social media risks cutting off a “lifeline for friendship” for disabled children and could push them into social isolation by preventing them from making connections online. Charities and high-profile figures in disability advocacy …

Early research suggests that some mental health conditions could stem from metabolic disorders. If so, the findings could change how we treat mental illness
I was recently reading Quine (1948) and came across this passage: The physical conceptual scheme simplifies our account of experience because of the way myriad scattered sense events come to be ...

Litter-picking creatures emerge from underground for global franchise targeting nostalgic adults and gen Alpha Move over Paddington Bear. After almost 30 years off screen, the Wombles – the furry, litter-picking creatures who live beneath Wimbledon Common – are set for a comeback. The characters, whose motto is “Make Good Use of Bad Rubbish”, are being revived after the consolidation of the brand…


Rent the Intelligence, Own the Memory On Friday, a single government letter pulled a frontier AI model off the internet for everyone. The Commerce Department issued an export-control directive on Anthropic's Claude Fable 5 — the reported concern being that its guardrails could be jailbroken. To comply, Anthropic disabled it for all customers, not just foreign nationals. One letter at 5:21pm on a …

4E Therapeutics, Inc. ("4E"), an Austin-based neuroscience company developing next-generation treatments for chronic pain, today announced that it has been acquired by Eli Lilly and Company ("Lilly").

Rutgers Health study published in Genomic Psychiatry identifies an ultra-rare loss-of-function variant in a gene associated with psychosis and mood disorders in multiple family members.
“Longevity” — a buzzy catchall for the quest for a longer life — is having a moment. Tech titans like Peter Thiel, Mark Zuckerberg, and Jeff Bezos are spending billions to fund research into how to slow aging. Celebrities like Gwyneth Paltrow and Hailey Bieber are touting peptide use. And the world’s most powerful authoritarian […]
For decades, Florida was the archetypal presidential swing state — and as recently as 2016 and 2018, Democrats came close to winning statewide elections there.  Then things took a turn. After Ron DeSantis was elected governor in 2018, the Sunshine State moved solidly right of the country in 2020, and 2022 and 2024 brought double-digit […]
In a sense, Anthropic CEO Dario Amodei is getting what he wanted. Amodei has long argued that AI is becoming dangerously powerful — and thus, that regulatory restrictions on the technology are urgently needed. In an essay published last week, Amodei wrote that the release of cutting-edge AI models “should be blocked or reversed as […]
This story was originally published by Grist and is reproduced here as part of the Climate Desk collaboration. As the midterm elections approach, something strange has happened: Democratic politicians who once talked about climate change as the defining crisis of our time now barely mention it at all. The phrase has begun disappearing from their speeches, social medi…
IntroductionThe clinical translation of magnetic stimulation for central nervous system trauma is severely hindered by “parameter ambiguity”—the lack of evidence-based screen of stimulation protocol. Repetitive trans-spinal magnetic stimulation (rTSMS) holds therapeutic promise, yet its frequency-dependent effects on the complex spinal microenvironment remain poorly understood. To address this ga…
BackgroundAs a first-line treatment for acute ischemic stroke (AIS), tenecteplase (TNK) can cause adverse effects, such as depression, in AIS patients.ObjectiveThis study aims to elucidate the TNK target-related pathogenic mechanisms underlying major depressive disorder (MDD) in AIS patients.MethodsBy analyzing six public peripheral blood bulk datasets from AIS and MDD patients using integrative …
IntroductionUnderstanding how neurotransmitter systems organize into large-scale networks is essential for elucidating the mechanisms through which drugs, diseases, and behavioral states alter brain function. Existing imaging modalities such as functional MRI (fMRI) and positron emission tomography (PET) provide measures of hemodynamic and metabolic connectivity, but cannot noninvasively map neur…
IntroductionDysfunction in brain protein clearance mechanisms is thought to contribute to many neurodegenerative diseases, yet non-invasive assessment of these mechanisms in humans remains challenging. This study is the first to examine whether intravoxel incoherent motion (IVIM) diffusion MRI metrics, measures of water diffusion and fluid dynamics, are associated with pathological protein accumu…
Every git user eventually has that moment. The terminal returns. The working directory looks wrong. You type git log and the last two hours of work are simply not there. Usually, this is not data loss. It is a solvable problem, and git reflog is what solves it. What reflog actually is git reflog records every position HEAD has pointed to on your machine. Every commit, checkout, merge, rebase, and…
Every morning for three months, I re-explained myself to my coding agents. The same preferences. The same project structure. The same "no, we already tried that" conversation. Fresh context window, zero memory of anything we'd discussed before. Then I built Lorekeeper — an open-source memory layer for AI agents. Fixing the storage problem was the easy part. The hard part was making memory get bet…
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