Frontiers in Pharmacology | New and Recent Articles

BackgroundThrombocytopenia is a common adverse reaction of linezolid, often leading to severe complications. It is challenging to externally validate directly apply developed in other countries. We aim to develop and validate a risk prediction model of linezolid-associated thrombocytopenia (LAT) tailored to Vietnamese setting and to construct a simplified risk score calculation to support clinica…

The escalating global prevalence of carbapenem-resistant Gram-negative bacteria has significantly constrained therapeutic options, leading to the revived use of polymyxins. However, this resurgence has been paralleled by an increase in reports of associated adverse effects. No case of drug fever induced by polymyxin B (PMB) has been reported in the literature to date. We report the first case of …

BackgroundMetabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic lipid accumulation, with limited safe and effective therapeutic options currently available. Previous studies have demonstrated that mangiferin (MAN) alleviates nonalcoholic fatty liver disease via modulation of the AMPK and NLRP3 signaling pathways. However, there are no reports to date investigating…

Osteoporosis is a type of chronic disease that leads to elevated bone fragility and increased risk of fractures. The principal characteristics of this condition include reduced bone density and bone quality, impaired bone microstructure, and increased vulnerability to fractures. These fractures frequently occur in elderly individuals, resulting in significant health impairment and disruption to t…

BackgroundAge-related macular degeneration (AMD) is a severe eye disease that affects the macula, the central area of the retina. Current treatment consists of intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors. However, some patients remain refractory to treatment even after maximal anti-VEGF dosage. We longitudinally analyzed angiogenic and inflammatory biomarkers i…

ObjectiveTo investigate whether Gastrodin (Gas) attenuates doxorubicin (Dox)-induced cardiomyocyte senescence and apoptosis by regulating the AMPK/mTOR/4EBP1 signaling pathway and autophagy-related processes.MethodsA Dox-induced senescence model was established in H9c2 cardiomyocytes, and different concentrations of Gas (0.5 mM and 1 mM) were used for intervention. Senescence phenotypes were eval…

ObjectiveTo evaluate the protective effects and potential mechanisms of Yang He decoction (YHD), a classic traditional Chinese medicine formula, against cyclophosphamide (CTX)-induced immunosuppression in mice.MethodsAn immunosuppression model was established in Kunming mice via intraperitoneal injection of CTX (80 mg/kg). The mice were then treated with low, medium, or high doses of YHD (50, 100…

Cytokine release syndrome (CRS) is a severe immune-mediated toxicity frequently associated with immunotherapies such as CAR-T cells and bispecific T-cell engagers. Predicting CRS in humans remains difficult because current animal models and in vitro systems do not adequately capture the complex, systemic, and patient-specific nature of pathological inflammation. This perspective highlights key me…

BackgroundHispidulin is a bioactive flavonoid with promising antioxidant and anticancer properties; however, its poor aqueous solubility and stability limit its usage in therapeutic application. This study aimed to develop a suitable nanocarrier system to enhance its bioavailability and biological efficacy.MethodsHispidulin-loaded sodium carboxymethyl cellulose nanoparticles (HIS-CMC NPs) were sy…

BackgroundMetabolic syndrome (MetS) is a prevalent metabolic disorder with a rising global prevalence, serving as a risk factor for cardiovascular disease and type 2 diabetes. Huanglian Wendan Decoction, a commonly used formula in traditional Chinese medicine, has increasingly been used to treat MetS. This study aims to evaluate the efficacy and safety of Huanglian Wendan Decoction as an adjuncti…

Induction chemotherapy for pediatric Acute Lymphoblastic Leukemia (ALL) is highly curative but accompanied by a severe toxicity profile. Evaluating the genetic susceptibility to these adverse events could inform hypothesis-generating risk stratification. In this exploratory retrospective cohort study (N = 178), we investigated the influence of 14 candidate pharmacogenetic variants on the developm…

Background. Soyeom-Jetong (SJ) is a traditional East Asian polyherbal formulation composed of Paeonia lactiflora Pallas, Glycyrrhiza inflata Batal, and Corydalis yanhusuo W.T. Wang, traditionally used for treating inflammatory disorders. Given the central role of the NLRP3 inflammasome in inflammation-related pathologies, SJ is of particular interest as a potential anti-inflammatory modulator. Ho…

IntroductionPotentially inappropriate medications (PIMs), are common among residents of long-term care institutions (LTCIs) and may contribute to cognitive impairment (CIm). STOPPCog criteria, developed in 2025, support the identification of PIMs relevant to cognition and accuracy of dementia treatment.ObjectivesThe study aimed to identify PIMs according to the STOPPCog criteria among residents o…

BackgroundThe comparative cardiovascular effectiveness of different renin–angiotensin system (RAS) inhibitors in patients receiving maintenance hemodialysis remains uncertain, and current guideline recommendations largely assume therapeutic equivalence between angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB).MethodsUsing the TriNetX multi-institutional datab…

PurposeTo test the hypothesis that the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide improves retinal vascular function in mice with polymicrobial sepsis.MethodsThree groups of mice were studied. Two groups underwent cecal ligation and puncture to induce polymicrobial sepsis. One received vehicle and the other liraglutide via intraperitoneal injection starting 24 h before the proce…

ObjectiveIn this study, we developed a gelatin methacryloyl (GelMA) hydrogel composite for the simultaneous delivery of glucosamine (GlcN), platelet-rich plasma (PRP), and bone marrow–derived mesenchymal stem cells (BMMSCs). We systematically investigated its effects on cartilage endplate (CEP) cell behavior, inflammation, and oxidative stress, and evaluated its reparative efficacy in a murine ca…

IntroductionThe treatment of neuropathic pain with traditional and adjuvant analgesics is limited in efficacy and associated with severe adverse effects. Our group has previously shown that somatostatin, released from capsaicin-sensitive peptidergic sensory nerve terminals, mediates analgesic and anti-inflammatory effects at the peripheral and central levels via the somatostatin receptor subtype …

BackgroundHangovers can impair the ability to drive a car or work in industrial settings, in addition to causing unpleasant symptoms such as headaches and fatigue. As for reducing hangover symptoms, the effect of consuming water between drinks, often referred to as a “chaser,” has been empirically recognized; however, this effect has not been verified to date. The purpose of this study was to cla…