Frontiers in Pharmacology | New and Recent Articles

Sepsis-induced cardiomyopathy (SIC), a severe complication of sepsis, is strongly associated with significantly increased patient mortality, yet targeted therapeutic strategies remain lacking. Emerging evidence has established ferroptosis, an iron-dependent, lipid peroxidation-mediated regulated cell death pathway, as a critical pathogenic mechanism underlying SIC. Iron metabolism dysregulation p…

Background and PurposeInvestigating the assessment of innovative serum indicators with elevated sensitivity and specificity is crucial for enhancing the early diagnosis and prognosis of HCC (Hepatocellular carcinoma). This study aimed to evaluate the efficacy of COPA (Coatomer Subunit Alpha) in diagnosing hepatocellular carcinoma and assessing the effectiveness of immunotherapy.MethodsThis study …

Aconitum tanguticum (Maxim.) Stapf., commonly known as “Bangga” when used in combination with Aconitum naviculare (Brühl.) Stapf., is a traditional Tibetan medicine widely used in medicinal preparations. It is documented in the Si-Bu-Yi-Dian and Jing-Zhu-Ben-Cao and is mainly used to treat infectious and inflammatory conditions such as fever, liver and biliary disorders, lung diseases, gastroente…

BackgroundVoriconazole, a first-line therapy for invasive aspergillosis, exhibits variable pharmacokinetics due to CYP2C19 polymorphisms. However, severe hematological toxicity, particularly life-threatening neutropenia, remains under-recognized. The concomitant occurrence of dual severe organ toxicities in CYP2C19 poor metabolizers (PMs) poses a significant clinical challenge.CaseWe report a cas…

IntroductionPolycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders affecting women of reproductive age. Dendrobium officinale polysaccharides (DOP) have shown multiple pharmacological activities, but their therapeutic effects and underlying mechanisms in PCOS remain incompletely understood.MethodsA dehydroepiandrosterone (DHEA)-induced mouse model of PCOS was…

Glioma, especially glioblastoma multiforme (GBM), has become one of the major clinical challenges in the field of neurooncology due to its high invasiveness and significant multidrug resistance (MDR). The mechanism of drug resistance is complex and involves the synergy of many factors, including the overexpression of MDR related transporters such as P-glycoprotein (P-gp), multidrug resistance ass…

IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal barrier dysfunction and epithelial cell death. Necroptosis of intestinal epithelial cells (IECs) mediated by the RIPK1/RIPK3/MLKL pathway has emerged as a key driver of UC progression. Celastrol, a bioactive compound from Celastrus wilfordii, has shown anti-inflammatory potential, but its effec…

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with poor prognosis. Surgery is the only curative option for ACC, but recurrence remains high. Effective systemic therapies are still lacking in ACC. Diagnosis currently relies on integrated hormonal, imaging, and histopathological assessments. However, distinguishing ACC from benign adrenocortical adenoma (ACA) remains challengin…

ObjectiveThe integrity of the intestinal mucosal barrier is critical in the pathogenesis of Inflammatory Bowel Disease (IBD). While Astragaloside IV (ASIV) possesses potent anti-inflammatory properties, its specific effects on intestinal epithelial barrier function and the underlying mechanisms involving the Myosin Light Chain Kinase (MLCK) and Myeloid Differentiation Primary Response 88/TNF Rece…

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) compromises function and quality of life (QoL) and may precipitate chemotherapy modification. We evaluated longitudinal Patient-reported outcome measures (PROMs) during duloxetine-based CIPN management and explored clinical predictors of response.MethodsThis secondary longitudinal analysis was conducted within a randomized clinical cohor…

BackgroundSevere early-onset pregnancy-associated cholestasis with atypical features may reflect an intrahepatic cholestasis of pregnancy (ICP) component superimposed on underlying hepatobiliary disease. Evidence for bicyclol use during pregnancy is very limited.Case presentationA 34-year-old pregnant woman, developed palmoplantar pruritus and severe cholestasis at 15 weeks of gestation. She had …

BackgroundPD-1/PD-L1 inhibitors combined with chemotherapy have improved survival outcomes in patients with driver mutation–negative non-squamous non-small cell lung cancer (non-sqNSCLC). However, the comparative efficacy, safety, and economic value of available PD-1/PD-L1 inhibitor–based regimens remain uncertain in China.MethodsWe conducted a network meta-analysis to indirectly compare the effi…

Quinazoline scaffolds are widely recognized in drug discovery for their diverse pharmacological profiles, and several quinazoline derivatives have been reported as phosphodiesterase 7A (PDE7A) inhibitors with potential anti-inflammatory effects. This study aimed to synthesize novel quinazoline derivatives, evaluate their anti-inflammatory activity and investigate their computationally predicted b…

BackgroundHyaluronidases are classically described as spreading factors that facilitate venom dissemination through extracellular matrix degradation, but their immunomodulatory roles remain poorly defined. In particular, comparative data between native scorpion venom hyaluronidase and commercial bovine hyaluronidase remain limited. This study investigated whether hyaluronidase treatment was assoc…

The pathogenesis of maculopathy remains incompletely understood, and emerging evidence implicates the gut–eye axis in retinal and macular diseases. Given that antibiotics with anti-anaerobic activity may disrupt gut microbial ecology, this study investigated their association with the risk of incident maculopathy. We conducted a nationwide population-based study using the National Health Insuranc…

BackgroundAcute pharyngitis and tonsillitis are common in children. Xiao’er Fengreqing Oral Liquid (XFQOL) shows potential benefits in previous studies of pediatric acute upper respiratory tract infections and influenza, but high-quality clinical evidence for pediatric acute pharyngitis/tonsillitis remains limited.MethodsThis multicenter, block-randomized, double-blind, double-dummy, active-contr…

Ageing is increasingly recognised as a microbiota-driven process, with dysbiosis contributing to oxidative stress, chronic inflammation, and cognitive and functional decline. Natural products, long valued in traditional medicine, are emerging as targeted modulators of the gut ecosystem. This systematic review synthesised current evidence on natural product interventions in ageing animal models. S…

Ribophorin I (RPN1), a core component of the oligosaccharyltransferase complex, is traditionally known for its role in endoplasmic reticulum-associated N-glycosylation. Recent studies have identified RPN1 as an emerging regulator of tumor progression and immunity. Aberrant RPN1 overexpression has been reported in multiple malignancies, including glioma, hepatocellular carcinoma, sarcoma, and trip…

BackgroundDespite the advent of targeted therapies, cisplatin remains a cornerstone in the management of non-small cell lung cancer Its systemic toxicity, however, often triggers neutropenic sepsis, a rapidly fatal oncological emergency. Traditional intermittent monitoring is inadequate here. Chemotherapy-induced “inflammatory silence” frequently masks the classical febrile response, leaving pati…