pediatrics

[Science] Investigators found platinum agents caused a specific mutational signature in the livers of children that was absent from other exposed normal tissues. They corroborated this observation through cell line and mouse experiments.

Chemotherapy, which saves the lives of many children with cancer, causes previously unknown DNA alterations in the liver and leaves genetic footprints in other healthy cells as well. These findings could potentially explain the higher risk of health problems later in life.

FRIDAY, Sept. 11, 2026 — The microscopic organisms that live on a baby’s skin could provide an early warning sign of eczema or food allergies, a new study says.Babies about to develop eczema or food allergies experience distinct changes in the...

Fetal dextro-transposition of the great arteries (d-TGA) represents a severe cyanotic congenital heart defect. Without effective intracardiac communication, affected neonates face life-threatening hypoxemia and acidosis shortly after birth. Recent investigations have unveiled an additional dimension: d-TGA patients experience compromised cerebral development and inadequate oxygen delivery beginni…

PurposeIron deficiency (ID) and iron deficiency anemia (IDA) are common in children with autism spectrum disorder (ASD) and may contribute to behavioral problems. We examined their association with internalizing and externalizing behavioral problems.MethodsThis cross-sectional study (October 2023 to March 2025) was conducted at a tertiary hospital in India. Of 179 children aged 2 to 18 years with…

The non-profit Boehringer Ingelheim Stiftung supports LMU clinician-scientist Daniel Kotlarz through its Rise up! program.

BackgroundIbuprofen overdose is commonly associated with gastrointestinal and renal toxicity; however, severe respiratory complications such as bronchial ulceration are rarely reported, and the underlying molecular mechanisms are poorly understood.ObjectiveTo investigate the potential molecular mechanisms of bronchial ulceration induced by an extreme ibuprofen overdose in a pediatric patient by i…

Complement-mediated diseases are individually rare, often rapidly progressive, and historically associated with high rates of permanent organ injury or death but are now among the most therapeutically actionable conditions in pediatric nephrology, hematology, and rheumatology. As demonstrated by thrombotic microangiopathy, and hemolytic uremic syndrome in particular, diagnostic delay can contribu…

Blood pressure thresholds commonly used to identify dangerously unstable vital signs in children may not signal trouble soon enough after a traumatic injury, according to a national study of more than 230,000 pediatric trauma patients.

Blood pressure thresholds commonly used to identify dangerously unstable vital signs in children may not signal trouble soon enough after a traumatic injury, according to a national study of more than 230,000 pediatric trauma patients.

Blood pressure thresholds commonly used to identify dangerously unstable vital signs in children may not signal trouble soon enough after a traumatic injury, according to a national study of more than 230,000 pediatric trauma patients.

ObjectiveTo evaluate the temporal association between voriconazole and hypomagnesemia in pediatric patients with hematologic diseases using prescription sequence symmetry analysis (PSSA) and to assess the utility of hospital information system (HIS)-based active drug safety surveillance.MethodsInpatient data were extracted from the Children’s Hospital of Chongqing Medical University from November…

IntroductionInfantile hemangiomas (IH) are the most common childhood vascular tumors, potentially complicated by ulceration and permanent functional or aesthetic sequelae. Current treatments include corticosteroids, β-blockers, and lasers, among others, existing evidence relies predominantly on direct pairwise comparisons. Consequently, the relative benefits and risks across these modalities rema…

TUESDAY, Sept. 8, 2026 — A growing number of younger children are being prescribed weight-loss drugs like Ozempic or Zepbound to treat their obesity, a new study says.While it’s still relatively rare to see children younger than 12 prescribed GLP-1...

A baby boy from Derbyshire has made medical history by becoming the world's inaugural patient to undergo pioneering treatment for a severe skull abnormality using revolutionary springs crafted from a special metal alloy. Rory Potter, now aged one, received his diagnosis of severe sagittal craniosynostosis, a rare condition in which the skull bones fuse prematurely before birth, shortly following …

Premature babies born across England have more equitable access to a treatment that reduces the risk of cerebral palsy, following a national care improvement programme, and according to new research led by the University of Bristol.

BackgroundCoagulopathy is a common risk factor in the occurrence of intraventricular hemorrhage (IVH) and subsequent poor neurological outcomes in preterm infants. The causal effect of fresh-frozen plasma (FFP) transfusion and IVH needed to be identified urgently.MethodsWithin the framework of target trial emulation (TTE), we mimic the process of a randomized controlled trial based on retrospecti…

The number of US children aged below 12 years old who are prescribed GLP-1 weight-loss drugs such as Wegovy, Zepbound, and Saxenda has increased by 310 times from 2019 to June 2026, according to new research. The study was conducted by researchers from New York University (NYU) Langone Health, US. It found that prescriptions for weight loss medications are less common for children aged eight to 1…