Science News

[Cancer Gene Therapy] Researchers discovered a pronounced overexpression of NAT10 in prostate cancer tissues and cell lines, which correlated with enhanced cellular proliferation, migration, invasion, and overall tumor growth.

[Oncogenesis] Scientists elucidated that BCL-xL is the major pro-survival protein in prostate cancer cell lines after docetaxel treatment, which can be reverted using BH3 mimetics or PROTAC strategies against this protein.

[University of Mississippi Medical Center] University of Mississippi Medical Center research to study the mechanisms of prostate cancer bone metastasis and evaluate new therapies has gained nearly $2.6 million in funding from the National Cancer Institute.

[Nature Reviews Urology] Unconventional T cells — including γδ T cells, mucosal-associated invariant T cells, NK T cells, double-positive and double-negative- T lymphocytes — are an underexplored component of immune surveillance in urological cancers. Emerging evidence suggests that each subset exhibits context-dependent behaviour across prostate cancer, bladder cancer, and renal cell carcinoma.

[Trends in Cancer] Researchers explore the key immune-evasive features of prostate cancer, the contribution of the tumor microenvironment, and the immunotherapeutic strategies that have been clinically evaluated to improve outcomes in patients with advanced disease.

[Clinical Cancer Research] Scientists identified SPEN inactivation as a driver of androgen receptor pathway inhibitor resistance. SPEN inactivation results in upregulation of cell cycle proliferation and basal/stem cell activity as well as increased translation of pro-oncogenic genes.

[Journal of Clinical Investigation] To investigate the immunomodulatory effects of poly(ADP-ribose) polymerase inhibitors in an unbiased manner, researchers performed bulk RNA sequencing on homologous recombination repair-proficient MycCaP cells treated with the PARP inhibitor olaparib versus vehicle control.

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Investigators identified the chromatin remodeler HELLS as a critical oncogenic driver in prostate cancer and elucidated a previously unrecognized post-translational cascade that governs its protein stability.

[The Journal of Clinical Investigation] Scientists showed that EZH2 inhibitors synergize with PI3K, AKT, or mTORC1 inhibitors to kill CRPC in vitro and promote tumor regression in vivo .

[Amsterdam UMC] KWF announced 34 research projects that will receive funding in its latest round — including 8 projects involving Cancer Center Amsterdam (CCA) researchers.

[Advanced Science] Scientists validated the biological function of HOXC11 in colorectal cancer (CRC) proliferation and metastasis and established its clinical relevance in CRC.

[Cell Reports Methods] Investigators established a scalable, microarrayed 3D human intestinal organoid platform enabling high-throughput, single-organoid-resolution phenotyping of cytokine-induced epithelial injury and recovery.

[Cancer Letters] Researchers demonstrated that PEBP4 was upregulated in colorectal cancer (CRC) specimens and was also elevated in the serum of CRC patients.

[Communications Biology] Scientists reported that the expression of collapsin response mediator protein 4 (CRMP4) is highly expressed in colorectal cancer cells carrying wild-type tumor protein p53 (p53) under hypoxic conditions and can be compromised by p53 or HIF1α knockdown.

[Cancer Gene Therapy] Vacuolar protein sorting-associated protein 35 (VPS35) was identified as a potential predictive biomarker for chemotherapy response in gastric cancer.

[Experimental Cell Research] Investigators aimed to elucidate the role and mechanism of FAM105A in gastric cancer (GC) progression. FAM105A was significantly overexpressed in GC tissues, and its high expression correlated with advanced TNM stage and poor prognosis.

[Trends in Molecular Medicine] The authors describe how gut microbiota affects drug metabolism on a mechanistic level and outline the interactions of specific microbes and their products with chemo-, targeted, and immunotherapies employed in colorectal cancer.

[Amsterdam UMC] KWF announced 34 research projects that will receive funding in its latest round — including 8 projects involving Cancer Center Amsterdam (CCA) researchers.

[Nature] Scientists established mosaic analysis with double markers technology in mouse embryonic stem cells to probe radial glial progenitor lineage progression in a self-organizing cortical organoid system.

[Developmental Cell] The authors generated elongating heart organoids from hiPSCs that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis.