cell-biology

Researchers found that TIMP2 supports microglial function and reduces age-related cellular changes associated with inflammation in mice. As the brain grows older, its immune cells can become less effective at clearing debris and controlling potentially harmful responses. Researchers at The Icahn School of Medicine at Mount Sinai have identified a role for TIMP2, a protein [...]

Researchers from Linköping University and the Princess Máxima Center in the Netherlands have discovered how the so called

Inside every cell, thousands of proteins must reach the right place at the right time. Helping coordinate this complex logistics network are centriolar satellites-tiny, membrane-less organelles that play important roles in protein trafficking, cell division, and the formation of cilia.

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-76862-0 Small cell lung cancer (SCLC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment (TME) resistant to Immune checkpoint inhibitor (ICI) therapy. Here, the authors define an XPO1-TRIM21-TNFSF15 axis that promotes the polarization of immunosuppressive TREM2+ macrophages, which…

Cancer drugs are often designed to block specific molecular targets, but what happens after they enter a cell is not always well understood. A new study published in Biophotonics Discovery demonstrates how advanced imaging technology can help answer that question. Using super-resolution microscopy, researchers tracked the cancer drug sunitinib inside living cells and observed how […]

Mitochondria have long been understood as the powerhouse of the cell. Are they also the powerhouse of rejuvenation?

For a new drug to work in the human body, it must make its way to the exact cell type where it's needed and then, in many cases, get inside the cells.

​In a new research report, scientists at Johns Hopkins Medicine say they have developed a technology that allows them to capture a 3D molecular "snapshot" of hundreds of hair follicles as they develop and then reconstruct the fourth dimension - time - to effectively create a stop-motion animation of how this organ forms.

Consciousness remains incompletely explained at the anatomical, biophysical, and functional levels. Although existing theories characterize key functional correlates of conscious experience—including global broadcasting, information integration, attentional selection, working-memory-based awareness, and electromagnetic field dynamics—none has yet identified a specific cellular mechanism embedded …

Biology doesn’t happen at one scale. Molecular interactions unfold in milliseconds and nanometers, while disease-associated change such as in Alzheimer’s spreads across millimeters of brain tissue.

On 26 April, a sun-drenched country hotel in East Sussex set the stage for an intensive three-day workshop that brought together 30 leading metabolism researchers across cell biology, mitochondrial biology, developmental biology, cancer biology and systems biology. Organised by Lydia Finley and Wilhelm Palm, the meeting provided a forum for sharing unpublished findings, assessing the [...] The po…