cell-biology

Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74204-8 Small cell carcinoma of the ovary, hypercalcemic type, is a rare, aggressive cancer caused by SMARCA4 inactivation and features wild-type p53. Here, the authors suggest that loss of SMARCA4 alters chromatin and reprograms p300 binding, undermining p53’s transcriptional repression and promoting cancer growth.

Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74081-1 This study investigates how bacterial cell polarity is controlled by an unconventional G-protein system, where dynamic protein interactions replace classical regulatory mechanisms to direct cell movement.

Collagen is often described as the body’s natural scaffolding. It gives strength and structure to skin, bones, tendons, organs, and many other tissues. For decades, biology textbooks have shown collagen as a long, stiff, rod-shaped molecule. But a surprising new study suggests that picture is only part of the story. Researchers at the Center for […] The post Our body’s most abundant protein behav…

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74320-5 Spatial and single-cell transcriptomics of patient-derived brain organoids reveal disrupted progenitor–neuron organization and local neuronal disarray, implicating spatially mosaic pathogenesis in autism heterogeneity.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74061-5 Inhibition of PLK4 is synthetic lethal in cancers with chromosome 17q TRIM37 copy number gain. Here, the authors show that while RP-1664 (PLK4 inhibitor) causes centrosome depletion in a TRIM37-dependent manner as high doses, low dose causes cell death in a TRIM37-independent manner via centrosome amplification …

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74448-4 Here, the authors describe four distinct DNA sequence patterns in nucleosomes that shape how transcription factors interact with chromatin, revealing previously hidden DNA-encoded rules governing nucleosome positioning and gene regulation.

Collagen, the protein that builds skin, bones, tendons and organs, exists inside cells as a liquid-like droplet rather than the long, rigid rod seen in textbooks over the last half century, according to a new study from the Centre for Genomic Regulation (CRG) in Barcelona.

A new study may have revealed a crucial cog in the biological machinery that spins...

Scientific Data, Published online: 13 June 2026; doi:10.1038/s41597-026-07626-0 Quantitative Proteomics Unveils Comprehensive Tissue-Specific VCP Interaction Networks in Mice

Cancer drugs can shrink fast-growing tumors. But sometimes a few tumor cells survive. These "persister" cells seed new tumors, forcing cancer patients into arduous cycles of testing and treatment.

Malcolm Brenner, an internationally recognized physician‑scientist renowned for his leadership in cell and gene therapy, has been tapped to lead the newly formed Houston Methodist Center for Cell and Gene Therapy.

A molecular geneticist at Montana State University has discovered a cellular process once believed impossible by scientists – the creation of the amino acid cysteine within a living cell when the cell's primary systems to do so fail. The discovery may one day lead to new cancer treatments.

By discovering retinal cell subgroups in mice, researchers hope to pinpoint an optimal cell type for transplantation to restore vision in blinding conditions

A bacterial pathogen that causes colitis and colorectal cancer creates a nutrient-rich niche and “rewires” epithelial cell signaling in the inflamed gut, which promotes bacterial colonization and disease, mechanisms that may be promising therapeutic targets, according to a recent study published in the journal Cell. The post Bacteria ‘Rewire’ Epithelial Cells and Drive Disease in the Gut appeared…

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-73856-w Here they show that PAR3 promotes bile canaliculus elongation and hepatocyte maturation by restricting ERK/MAPK signaling, linking liver architecture formation with functional maturation during development and regeneration.

Nature Cell Biology, Published online: 12 June 2026; doi:10.1038/s41556-026-01980-2 Bassot, Violy, Gorka, Cigalotto and colleagues identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and mitochondria bioenergetics, which may be potentially targeted to inhibit glioblastoma growth in vivo.

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74199-2 Ribosomes are crucial for protein synthesis and managing cellular stress. Here, authors show that ribosomal protein L11 acts as a global regulator, coordinating complex internal signaling to ensure proper bacterial survival during environmental stress.

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74304-5 Functional genomics in algae are limited by efficient methods that connect genotype and metabolic phenotype at single-cell resolution. Here the authors introduce an approach based on a genome-wide mutant library and a Raman Cytometer, discovering a carotenoid synthesis regulating pathway.