cell-biology

Scientists have taken a major step toward safely freezing and reviving brain tissue by preventing the microscopic damage normally caused by ice crystals. What if living tissue could be frozen for years, or even decades, and later revived without losing its function? Scientists searching for ways to make this possible have turned to an unlikely [...]

PhD is not nothing. This open letter tells the truth about the sacrifice, endurance, failure, and resilience behind earning a PhD in cell and molecular biology—and why the journey deserves respect. The post A PhD Is Not Nothing: An Open Letter to Those Who Dismiss the Journey appeared first on THE SCIENCE NOTES .

Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73471-9 Here they show that, during lumenogenesis, noncanonical autophagy drives formation of a single central cavity by controlling membrane recycling, while canonical autophagy supports its growth, and provide insights into tissue development from neural tube organoids.

Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73711-y Cells prevent the mitochondrial Ca2+ uniporter from causing Ca2+ overload and cell death by expressing the non-conductive regulator MCUb. Here, the authors rebuild Ca2+ conductance in MCUb, revealing the molecular basis of its regulatory function.

Nature Cell Biology, Published online: 25 May 2026; doi:10.1038/s41556-026-01958-0 Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of HSC lineage bias.

Nature Cell Biology, Published online: 25 May 2026; doi:10.1038/s41556-026-01987-9 During embryogenesis, morphogen signalling is known to pattern tissues as they remodel. Using genetic and optogenetic perturbations, together with theoretical frameworks of phase transitions and biochemical networks, we uncovered an autoregulatory feedback loop between morphogen gradients and the tissue material st…

Nature Immunology, Published online: 25 May 2026; doi:10.1038/s41590-026-02536-0 Waterfield and colleagues report the transcription factor RUNX1 expressed in mTECs profoundly influences the diversity of thymic mimetic cells that express tissue-specific antigens.

Scientists have uncovered a surprising twist in how cells behave when division goes wrong. Sometimes a cell successfully copies its DNA but fails to split into two, leaving it with double the genetic material — a mistake linked to aging, cancer, and other major diseases. Researchers discovered that not all of these failures are equal.

Scientists have long known that electric fields can guide cell movement by a process called electrotaxis. However, most studies rely on electrodes that touch the cell medium, creating currents that complicate the biochemistry. Now, researchers designed a wireless platform that delivers a unidirectional electric field (Wi-uEF) without measurable current. Using this system, they discovered that hum…

This book assembles experts from diverse fields to highlight aspects of and insights into epigenetics, RNA networking, virology, genetics, and cell biology that must be part of the Integrative Theory of Evolution. This theory illuminates how the abundance of epigenetic regulations, RNA group interactions, the role of viruses in cellular host organisms, and cell identity drive evolutionary process…

This in vitro study found that negatively charged SiO2 nanoparticles suppressed antigen-induced degranulation and activation-marker changes in IgE-sensitized mouse bone marrow-derived mast cells. By contrast, mTiO2 nanoparticles showed cytotoxic and pro-inflammatory effects, including enhanced DNP-induced IL-6 release, suggesting nanoparticle composition can shape early allergic immune responses.

A new review shines a spotlight on efferocytosis, a critical biological process responsible for the removal of dead cells, as a central force in promoting efficient wound repair and maintaining tissue balance.

Nature Communications, Published online: 23 May 2026; doi:10.1038/s41467-026-72817-7 CD19-specific chimaeric antigen receptor (CAR) T cell therapy has recently been evaluated for the treatment of systemic sclerosis (SSc). Here, the authors use multiomic analyses to demonstrate that CD19 CAR T cell treatment promotes skin tissue remodeling in patients with SSc.

Nature Communications, Published online: 23 May 2026; doi:10.1038/s41467-026-73208-8 The study shows that a subpopulation of brainstem astrocytes actively regulates breathing and brain states. Activating these cells alters respiratory patterns and increases sighing, revealing a key role in linking neural activity, arousal, and respiratory control.

Abstract Mechanistic target of rapamycin (mTOR) signaling pathway controls eukaryotic growth by regulating metabolism, translation, autophagy and cell cycle. Genetic deletion of renal mTORC1 led to a Fanconi-like syndrome with reduction of the renal cortex, tubular epithelial transport and perturbation of the endocytic machinery. Although the main scavenger receptor megalin remained unaltered, a …

Abstract Purpose of Review Quambalaria spp. are fungal pathogens originating from Australian eucalypt species that are becoming increasingly important globally. For example, Quambalaria eucalypti, which was once considered a minor pathogen, now poses a significant threat to plantation productivity and forest health across continents. Their spread has been made possible through the expansion of eu…