cell-biology

To properly understand aging, we have to understand what is slowly unravelling in individual cells. What is it that makes our cells become less efficient and more vulnerable to disease over time, and eventually break down? A new study, led by researchers from the Fritz Lipmann Institute (FLI) in Germany, details new findings about how […]

Biology – the study of living things – can admittedly be a little reductive at...

Neurons receive thousands of signals via tree-like extensions called dendrites. Until now, these dendrites were thought to be relatively smooth cables that conduct electrical signals to the cell body.

By reproducing elements of human bone marrow on a chip, scientists have created a new tool that will help them gain new insights into how immune cells develop and function. The post Bone Marrow-on-a-Chip Model Offers New Window Into Immune Cell Development and Behavior appeared first on GEN - Genetic Engineering and Biotechnology News .

Johns Hopkins researchers developed CloudScope, a cloud-based microscope enabling continuous, remote brain imaging in freely moving mice, revealing disease progression, seizures, cellular changes and behavior over extended periods. The post CloudScope Enables Continuous Remote Monitoring of Brain Activity in Freely Moving Mice appeared first on GEN - Genetic Engineering and Biotechnology News .

Nature, Published online: 11 September 2026; doi:10.1038/d41586-026-02828-3 Small trial hints at regenerative potential of bone-seeking marrow cells.

[Experimental & Molecular Medicine] Researchers used a human embryonic stem cell-derived hepatocyte organoid differentiation model, identifying JMJD3 as a critical regulator of hepatocyte maturation through metabolic–epigenetic coupling.

[Stem Cell Reports] The authors used the direct reprogramming of fibroblasts into induced hepatocyte-like cells as a model to address why some cells reprogram under identical conditions, while others do not.

Nature Communications, Published online: 11 September 2026; doi:10.1038/s41467-026-77588-9 Environmental cues, such as pH, determine cellular differentiation and function, including that of immune cells. Here the authors identify SLC4A7, a Na + /HCO3–cotransporter as a critical and specific regulator of plasmablast differentiation genetic deletion of which in mice impairing antibody responses.

Nature Communications, Published online: 11 September 2026; doi:10.1038/s41467-026-77609-7 Post-transcriptional regulation of cardiac fibroblast phenotypes during fibrotic cardiac remodeling remains poorly defined. Here, the authors demonstrate that RNA-binding protein PTBP1 regulates alternative splicing to direct the profibrotic response in multiple cardiac injury models.

In a study published in Nature Communications, Krystle Kalafut, now a fellow in the Hotamışlıgil Lab, and colleagues found that a molecular mechanism involving AKT-mediated phosphorylation of TSC2 is the...

Nature Cell Biology, Published online: 11 September 2026; doi:10.1038/s41556-026-02063-y Xie, Tan, Mo and colleagues show that a liver-specific bipartite structure of the active X chromosome is lost early in hepatocarcinogenesis in mice and humans, driving X-linked gene activation and premalignant transformation, particularly in males.

Nature Cell Biology, Published online: 11 September 2026; doi:10.1038/s41556-026-02066-9 Xu, Guo et al. report suppressor screens in Caenorhabditis elegans to counteract tubulin mutants. They report several missense variants in tubulin genes that may restore microtubule architecture and dynamics, which may have some conservation in mammalian cells.

Scientific Reports, Published online: 11 September 2026; doi:10.1038/s41598-026-70215-z Transcriptomic responses of mitochondrial and immune pathways to chronic white-light exposure in the mouse retina

Scientific Reports, Published online: 11 September 2026; doi:10.1038/s41598-026-70765-2 Inspiratory temporal patterning and mechanical architecture shape regional energy distribution in a multicompartment lung model

ObjectiveTo investigate the effects of propranolol on the malignant biological behaviours of renal cancer cells and explore the potential involvement of the IL-6/PI3K/AKT signalling axis.Methods786-O and Caki-2 ccRCC cells were treated with gradient propranolol, followed by CCK-8, wound-healing, Transwell and flow cytometry assays to test cell proliferation, migration, invasion and apoptosis. Wes…

Panelists at the 2026 TIME100 Health Leadership Forum discussed how to make it easier for patients to get treated with lifesaving cell therapies.

The brain is a black box of densely packed neurons, blood vessels and immune cells, all locked away in a sealed skull. WashU's Song Hu has dedicated his career to unlocking that puzzle box by developing new ways to "see" inside. His team's newest innovation could give researchers a new view of how brain cells and blood vessels work together and what happens when the coupling between the two break…

The brain is a black box of densely packed neurons, blood vessels and immune cells, all locked away in a sealed skull. WashU's Song Hu has dedicated his career to unlocking that puzzle box by developing new ways to "see" inside. His team's newest innovation could give researchers a new view of how brain cells and blood vessels work together and what happens when the coupling between the two break…