A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Michael D. Milsom
Nature Cell Biology, Published online: 25 May 2026; doi:10.1038/s41556-026-01958-0 Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of HSC lineage bias.