biology

Mechanical forces regulate development, homeostasis, and repair in the skin, lung, and cornea—external barrier organs that are exposed to stretch, shear, and stiffness. Dysregulated mechanotransduction drives fibrosis, inflammation, and impaired repair via conserved pathways [Piezo1 (Piezo-type mechanosensitive ion channel 1), TRPV4 (transient receptor potential vanilloid 4), and integrin–YAP (Ye…

Research has shown that American twinflower cannot pollinate close relatives, and needs less closely-related individuals nearby in order to successfully set seed. Thus, if a population becomes small or isolated from others, it is more likely to die out. Full profile for this plant

A cup of yogurt looks simple, but scientists say its effects on the body may be more complicated than the nutrition label suggests. For generations, fermented milk has been valued as a nourishing food in many cultures. Researchers are now trying to understand whether yogurt may also help support healthy aging and lower the risk […] The post The Surprising Science Behind a Bowl of Yogurt appeared …

After AAV directed evolution led to discovery of a new blood-brain-barrier (BBB) receptor (carbonic anhydrase IV) which facilitates transcytosis, Ding et al. linked a small molecule binder of CA-IV to antibodies, allowing the antibodies to traverse the BBB. This is a major advance since it represents the first time that a receptor target discovered via […]

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