Nature Cell Biology

Nature Cell Biology, Published online: 12 June 2026; doi:10.1038/s41556-026-01980-2 Bassot, Violy, Gorka, Cigalotto and colleagues identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and mitochondria bioenergetics, which may be potentially targeted to inhibit glioblastoma growth in vivo.

Nature Cell Biology, Published online: 12 June 2026; doi:10.1038/s41556-026-01975-z This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and academic journey as an LGBTQIA+ immigrant.

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-02000-z Publisher Correction: Epigenetic programming by H3K23ac defines lineage fate of Meg3 + haematopoietic stem cells and drives immune ageing

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01986-w Zollo et al. examine DRP1 behaviour at mitochondria: DRP1 diffuses along mitochondria in helical-like patterns influenced by MID49/MID51, scanning the organelle surface and stalling at preconstricted fission sites.

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01985-x Wang, Liang and colleagues show that the TEAD1 transcription factor can organize micrometre-sized nuclear biomolecular condensates independently of active transcription. TEAD1 condensates may act as depots for excess TEAD1.

Nature Cell Biology, Published online: 11 June 2026; doi:10.1038/s41556-026-01993-x This Perspective highlights the use of current proteomics technologies in defining stage-specific reprogramming events to understand reproductive ageing, improve oocyte quality, and refine the outcomes of assisted reproductive technology (ART).

Nature Cell Biology, Published online: 10 June 2026; doi:10.1038/s41556-026-01965-1 De Belly et al. show Rac induces membrane-tension-mediated mTORC2 activation to stimulate long-range Rho activation. Meanwhile, Rho-mediated contractility and blebbing at the opposite side of the cell may lead to PI3K-dependent Rac activation.

Nature Cell Biology, Published online: 10 June 2026; doi:10.1038/s41556-026-01974-0 Oshio, Shiiba and colleagues show that HMOX2, which catalyses haem degradation, supplies haem-derived iron to mitochondria at ER–mitochondria contact sites in a process mediated by the mitochondrial ubiquitin ligase MITOL, also known as MARCH5/MARCHF5.

Nature Cell Biology, Published online: 08 June 2026; doi:10.1038/s41556-026-01999-5 Author Correction: Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum

Nature Cell Biology, Published online: 02 June 2026; doi:10.1038/s41556-026-01951-7 PARP inhibitors kill cancer cells by trapping poly(ADP-ribose) polymerase 1 (PARP1) on DNA. A study now shows that cancer cells use a specialized form of autophagy to extract and degrade trapped PARP1, limiting the efficacy of PARP-trapping drugs. Blocking this escape route can re-sensitize resistant tumours.

Nature Cell Biology, Published online: 02 June 2026; doi:10.1038/s41556-026-01961-5 Hoslett et al. show that trapped PARP1 is cleared from the nucleus by nucleophagy involving the autophagy receptor TEX264 and p97. Inactivation of nucleophagy resensitizes acquired resistance of BRCA1-deficient cells to PARP inhibitors.

Nature Cell Biology, Published online: 01 June 2026; doi:10.1038/s41556-026-01962-4 He, Wang, Ding and colleagues report a transcriptomic atlas of human female reproductive tract segments from fetuses at gestational weeks 10 to 25.

Nature Cell Biology, Published online: 01 June 2026; doi:10.1038/s41556-026-01972-2 This Review discusses the roles of ferroptosis in shaping the immune landscape in glial tumours and highlights potential strategies that combine ferroptosis induction with immunotherapy for a durable control of gliomas.

Nature Cell Biology, Published online: 01 June 2026; doi:10.1038/s41556-026-01971-3 Cao, Lin, Feng, Chen, Wu and colleagues develop a mouse developmental single-cell atlas covering 2-cell stage through to birth.

Nature Cell Biology, Published online: 01 June 2026; doi:10.1038/s41556-026-01966-0 Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate intracellular signalling.

Nature Cell Biology, Published online: 28 May 2026; doi:10.1038/s41556-026-01948-2 Valdivieso, Rozmaric et al. show that wounding rapidly induces a senescent state in skin cells involving p21 protein induction, without the need for new transcription. These senescent cells are beneficial to early stages of healing.

Nature Cell Biology, Published online: 27 May 2026; doi:10.1038/s41556-026-01973-1 Jiang et al. show that SLC25A12 interacts with the mitochondrial protease OMA1, enabling activation of integrated stress response during mitochondrial damage. This role is independent of SLC25A12’s transport activity.

Nature Cell Biology, Published online: 26 May 2026; doi:10.1038/s41556-026-01963-3 Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid droplets.

Nature Cell Biology, Published online: 26 May 2026; doi:10.1038/s41556-026-01955-3 Lipid droplets acquire hairpin-containing proteins from the ER, but how they travel to lipid droplets and subsequently accumulate has remained unclear. With single-molecule tracking, a study now shows that persistent connections serve as bridges to lipid droplets, where nanoscale domains corral arriving proteins.

Nature Cell Biology, Published online: 26 May 2026; doi:10.1038/s41556-026-01960-6 Wei et al. show that Meg3+ haematopoietic stem cells (HSCs) expand upon ageing and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocyte/platelet and myeloid skewing in aged HSCs.