Nature Cell Biology

Nature Cell Biology, Published online: 21 August 2026; doi:10.1038/s41556-026-02039-y We present an updated reporter as the most sensitive readout for cGAS activation. Using this biosensor, we show that cGAS activation during genotoxic stress is rare, and that it is not driven by micronuclei. Instead, subsets of chromosome bridges and complex DNA structures containing DNA–RNA hybrids were found t…

Nature Cell Biology, Published online: 21 August 2026; doi:10.1038/s41556-026-02037-0 Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chromatin bridges as potential cGAS activators.

Nature Cell Biology, Published online: 21 August 2026; doi:10.1038/s41556-026-02053-0 This Perspective discusses emerging evidence for non-cell-autonomous propagation of ferroptotic cell death and highlights the mechanisms that underlie its restriction in tissues, as well as ferroptosis surveillance beyond the cellular level.

Nature Cell Biology, Published online: 20 August 2026; doi:10.1038/s41556-026-02046-z Long recognized for its roles in autophagy and endosomal trafficking, phosphatidylinositol 3-kinase class III (PI3K-3) is now shown to also function in the nucleus. A recent study shows that PI3K-3 associates with the transcriptional machinery and a chromatin-modifying complex, and contributes to transcriptional…

Nature Cell Biology, Published online: 14 August 2026; doi:10.1038/s41556-026-02048-x Kim et al. demonstrate a non-canonical function for EZH2 in modulating cholesterol metabolism and tumour development by interacting with SREBP2, which may be targeted by PROTACs to disrupt its oncogenic activity.

Nature Cell Biology, Published online: 14 August 2026; doi:10.1038/s41556-026-02036-1 Metabolic adaptation functions as an important selective bottleneck during tumour development. A study reveals that in response to glucose starvation, a metabolite from the TCA cycle is leveraged to enhance translation of the transcription factor NRF2, providing a critical adaptive response against disulfidptosi…

Nature Cell Biology, Published online: 10 August 2026; doi:10.1038/s41556-026-02049-w Early human crosstalk

Nature Cell Biology, Published online: 10 August 2026; doi:10.1038/s41556-026-02051-2 A chromatin remodeller silences SINE retrotransposons

Nature Cell Biology, Published online: 10 August 2026; doi:10.1038/s41556-026-02060-1 Author Correction: HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance

Nature Cell Biology, Published online: 10 August 2026; doi:10.1038/s41556-026-02043-2 Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on the transcription factor Etv1 and is dynamic during neuronal maturation.

Nature Cell Biology, Published online: 07 August 2026; doi:10.1038/s41556-026-02042-3 Chen, Xu, Zhou, Wu et al. report that a citric acid cycle enzyme OGDH regulates METTL3 succinylation and its activation as an m6A reader, thereby modulating NRF2 translation, disulfidptosis evasion and tumour growth.

Nature Cell Biology, Published online: 07 August 2026; doi:10.1038/s41556-026-02016-5 Li et al. report that FLT3 inhibition impairs selenoprotein translation and induces ferroptosis to suppress FLT3-mutant leukaemia. This can be counteracted by dietary vitamin E, which may disrupt the efficacy of tyrosine kinase inhibitors in treatment of acute myeloid leukaemia.

Nature Cell Biology, Published online: 07 August 2026; doi:10.1038/s41556-026-02033-4 How tumour cells rewire metabolic processes in response to changing nutrient availability in the tumour microenvironment is complex. Here, Zhang et al. define a role for PGAM1 in promoting autophagy in response to nutrient deprivation that competes with its catalytic function in glycolysis, which may explain sel…

Nature Cell Biology, Published online: 07 August 2026; doi:10.1038/s41556-026-02003-w The detailed study of membrane contact sites is challenging owing to their small size and highly dynamic nature. This Review highlights advanced imaging methods and available biosensors that can be used to elucidate their composition and dynamics.

Nature Cell Biology, Published online: 06 August 2026; doi:10.1038/s41556-026-02032-5 In clonal haematopoiesis, pre-cancerous mutant blood cells induce premature senescence in bone marrow stromal cells, creating an environment that allows mutant blood cells to outcompete healthy ones. Clearing senescent stromal cells reduces mutant clone expansion and delays progression to blood cancer in mouse m…

Nature Cell Biology, Published online: 06 August 2026; doi:10.1038/s41556-026-02025-4 Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.

Nature Cell Biology, Published online: 06 August 2026; doi:10.1038/s41556-026-02041-4 Aygenli et al. map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to establish tissue-specific circadian transcription.

Nature Cell Biology, Published online: 05 August 2026; doi:10.1038/s41556-026-02056-x Author Correction: Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

Nature Cell Biology, Published online: 05 August 2026; doi:10.1038/s41556-026-02044-1 Brandon, Robinson-Thiewes, Kaulage et al. report that targeted BRD4 recruitment enables transcription through H3K9me3/HP1-marked heterochromatin without erasing repressive marks, identifying condensate partitioning as a mechanism for gene desilencing.

Nature Cell Biology, Published online: 04 August 2026; doi:10.1038/s41556-026-02055-y Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis