Nature Cell Biology

Nature Cell Biology, Published online: 04 May 2026; doi:10.1038/s41556-026-01949-1 Li, Huo, Zhang, Liu and colleagues report that the transcripts of genes involved in haematopoietic stem cell function share a protective mechanism against RNA decay through a non-canonical function of NAT10, independent of its N4-acetylcytidine catalytic activity.

Nature Cell Biology, Published online: 01 May 2026; doi:10.1038/s41556-026-01952-6 We introduce lipid-trap mass spectrometry (LTMS), a technique to systematically identify lipid–protein interactions directly captured from live mammalian cells. By applying LTMS to proteins associated with the cell membrane during cytokinesis, we revealed that proteins bind specific lipid species, which suggests th…

Nature Cell Biology, Published online: 01 May 2026; doi:10.1038/s41556-026-01929-5 We developed a rapid endoplasmic reticulum (ER) immunoprecipitation strategy to isolate ER fractions and, by using it, identified SLC33A1 as an ER transporter that exports oxidized glutathione. This finding provides insight into how the ER sets redox balance and provides a framework to define how ER metabolism is c…

Nature Cell Biology, Published online: 30 April 2026; doi:10.1038/s41556-026-01936-6 Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1.

Nature Cell Biology, Published online: 30 April 2026; doi:10.1038/s41556-026-01910-2 Yu, Li and colleagues explore the metabolome of neurons, microglia and astrocytes under normal, ageing and Alzheimer’s disease conditions. They find enrichment of glutathione and polyamine metabolism in microglia, which decreased with ageing and in Alzheimer’s disease.

Nature Cell Biology, Published online: 29 April 2026; doi:10.1038/s41556-026-01944-6 The innate immunity sensor cGAS detects cytosolic DNA. A study by Song et al. shows that nuclear cGAS slows replication by binding reversed forks, but ATM displaces it to fine-tune fork speed. In ATM‑deficient cells, persistent cGAS causes fork collapse and cytosolic DNA release, activating interferon signalling.

Nature Cell Biology, Published online: 29 April 2026; doi:10.1038/s41556-026-01931-x Song et al. report that ATM maintains replication fork speed by counteracting chromatin-bound cGAS-induced fork slowing. They show that ATM and ATR phosphorylate MRE11 to release cGAS from chromatin in a process dependent on MRE11 nuclease activity.

Nature Cell Biology, Published online: 28 April 2026; doi:10.1038/s41556-026-01959-z Author Correction: A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Nature Cell Biology, Published online: 28 April 2026; doi:10.1038/s41556-026-01941-9 Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K9me3 heterochromatin and genome stability.

Nature Cell Biology, Published online: 27 April 2026; doi:10.1038/s41556-026-01938-4 Kozlova et al. report a functional role for NDRG1 in regulating R-loops and DNA repair, thereby linking cancer-associated fibroblast-derived extracellular matrix to chemotherapy responses in pancreatic cancer.

Nature Cell Biology, Published online: 27 April 2026; doi:10.1038/s41556-026-01943-7 Tandukar et al. dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution.

Nature Cell Biology, Published online: 24 April 2026; doi:10.1038/s41556-026-01921-z D’Ambrosio et al. screen 10,480 electrophilic compounds for senolytic effects and show that senolytic chloroacetamides or GPX4 inhibitors selectively kill senescent cells by ferroptosis.

Nature Cell Biology, Published online: 24 April 2026; doi:10.1038/s41556-026-01937-5 Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.

Nature Cell Biology, Published online: 24 April 2026; doi:10.1038/s41556-026-01939-3 Wang et al. find that leukaemic stem cells preferentially localize to the metaphysis bone marrow niche and lose stemness when mobilized to the central marrow. Targeting DPP4–CXCL12–GPC3 disrupts this niche and enhances leukaemia treatment.

Nature Cell Biology, Published online: 23 April 2026; doi:10.1038/s41556-026-01945-5 This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.

Nature Cell Biology, Published online: 08 April 2026; doi:10.1038/s41556-026-01909-9 This Perspective proposes the use of an integrative embedded ethics approach to evaluate human stem-cell-based embryo models and outlines a nested benchmarking strategy to periodically evaluate their scientific and ethical status.

Nature Cell Biology, Published online: 16 April 2026; doi:10.1038/s41556-026-01934-8 NK progenitors against cancer

Nature Cell Biology, Published online: 17 April 2026; doi:10.1038/s41556-026-01922-y Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an endoplasmic reticulum oxidized glutathione (GSSG) exporter in mammalian cells.

Nature Cell Biology, Published online: 16 April 2026; doi:10.1038/s41556-026-01935-7 GPX1 dictates in vivo ferroptosis

Nature Cell Biology, Published online: 17 April 2026; doi:10.1038/s41556-026-01930-y Sun et al. present a stem cell-derived embryo model recapitulating certain aspects of human peri-gastrulation, including the formation of trilaminar disc-, amnion- and yolk sac-like structures.