bioinformatics

AlphaFold and the Protein Folding Revolution: What Developers Need to Know Protein folding was a 50-year problem. Scientists called it the "holy grail of biology" — the question of how a string of amino acids spontaneously folds into a precise 3D shape that determines its function. Then in 2020, DeepMind's AlphaFold solved it. Not approximately. Not theoretically. Solved it well enough that the o…

Published on June 6, 2026 2:02 PM GMT I'm leading a non-profit team building a pathogen-agnostic early-warning system . As AI systems become increasingly capable substitutes for expert human biologist expertise, the risk that someone could engineer a pathogen to spread widely before detection is going up. We've made great progress and we're now running the world's largest metagenomic biosurveilla…

Scientific Data, Published online: 06 June 2026; doi:10.1038/s41597-026-07585-6 A Dataset of Benchmark Boolean Models for Gene Regulatory Networks

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74000-4 Mapping cell dynamics from static data is a challenge in genomics. Here, authors introduce ArchVelo, a computational method for modeling transcription dynamics and trajectory inference using chromatin accessibility archetypes in single-cell multi-omics, and infer new T cell transitions in infection.

Scientific Data, Published online: 05 June 2026; doi:10.1038/s41597-026-07526-3 DNA methylation profiles of quail blood cells by whole-genome bisulfite and Oxford Nanopore sequencing

Nature Communications, Published online: 05 June 2026; doi:10.1038/s41467-026-73863-x In this work, the authors develop a machine learning–based enhanced sampling workflow to target the intrinsically disordered AR-NTD, identifying druggable conformations and enabling transferable modeling of ligand binding for rational drug discovery.

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investigators at Weill Cornell Medicine and the New York Genome Center.

The Jane Goodall Institute worked with AWS to identify AI use cases. They're digitizing decades of research and preserving Goodall's contributions.

Purpose: More than 50 inherited retinal diseases are known, with rod photoreceptor functional loss serving as an early indicator in nearly half of them. The “optoretinogram” is a relatively new assay that detects optical changes in cells in response to stimuli. This tool has excellent potential for providing insights into the earliest functional changes of rod photoreceptors, with the potential t…

Nature Communications, Published online: 04 June 2026; doi:10.1038/s41467-026-73948-7 Obtaining matched spatial transcriptomic and epigenomic measurements from the same cell remains technically challenging. The authors develop a computational framework ISON to integrate widely available spatial transcriptomics data with sc-multiome profiles to infer spatial chromatin accessibility and gene regula…

Scientific Data, Published online: 04 June 2026; doi:10.1038/s41597-026-07557-w A chromosome-level assembly of the alpine snow alga Chloromonas typhlos

Imagine a train parked at the station. Passengers climb aboard and find their seats. Conductors move up and down the aisles, checking tickets.

Scientific Data, Published online: 03 June 2026; doi:10.1038/s41597-026-07565-w Chromosome-level genome assembly of the small-sized Taihang donkey ( Equus asinus )

I am working with limb measurements and have created several functional ratios from them. All my raw measurements are in millimetres (mm). Example of a ratio I am using: humerus diameter (mm) / ...

This comparative analysis synthesizes two 2026 frameworks that approach stress resilience from opposite causal directions: Bulgaria’s Affective Endocrine Integration model, grounded in the Core Emotion Framework (CEF), and Candow et al.’s Creatine Supplementation for Brain Metabolic Stress, grounded in cerebral bioenergetics. Bulgaria advances a top down structural constructivist theory in which …