bioinformatics

Delve into the fascinating world of organoid intelligence at XPANSE 2024 in Abu Dhabi. Presented by Dr. Thomas Hartung, Professor of Medical Microbiology at Johns Hopkins University, this session explores the cutting-edge research and potential of lab-grown organoids to revolutionize computing, medicine, and neuroscience. XPANSE, the world’s first visioning of the future with exponential technolo…

The search for “alien” intelligences isn’t only looking to outer space: some biologists are convinced that weird and wonderful forms of intelligence already exist right here on earth, and that they hold the key to understanding intelligence itself. In the first of a two part series, Michael Levin tries to shake us out of any […]

Scientific Data, Published online: 13 June 2026; doi:10.1038/s41597-026-07627-z Chromosome-level and high-contiguity genome assembly and annotation of the greasyback shrimp Metapenaeus ensis

Not so long ago, DIY biology mostly meant extracting DNA from strawberries or growing mold in a petri dish for a school science project. Those experiments are still around, but the world of amateur biology has evolved considerably over the past decade.  Today, a growing network of community biology labs and citizen scientists is making biotechnology more […] The post DIY biology experiments: how …

Turning (Protein) language model spaces into in silico laboratories for Scientific (biological) discovery.

Nature Communications, Published online: 11 June 2026; doi:10.1038/s41467-026-74196-5 E-CloudBind improves drug-protein interaction (DPI) prediction by combining electron cloud representations with molecular graphs, enabling robust performance across low-resolution, predicted, and out-of-distribution structures for drug discovery.

This work extends the geometric framework introduced in Geometric Dynamics of Human Olfactory Identity toward a general theory of biological states based on manifold geometry, structural stability, and spectral organization. Starting from high-dimensional olfactory population data, a reduced biological manifold is constructed through covariance analysis and spectral decomposition. Within this man…

BackgroundA better understanding of the response of granulosa cells to exogenous hormone stimulation and how this impacts the complex interplay between the granulosa cells and the oocyte is crucial for the optimal management of infertile couples seeking IVF treatment.MethodsGranulosa and cumulus cells (G + CCs) from women with different degrees of ovarian responsiveness to controlled ovarian hype…

Nature Communications, Published online: 10 June 2026; doi:10.1038/s41467-026-74272-w Single cell RNA sequencing expanded the possibilities of capturing immune repertoires in lymphocytes but assembling long sequences from the individual reads, especially in naive and memory B cells with low expression of immunoglobulin transcripts is challenging. Here the authors present a computational tool to a…

ObjectivesUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by epithelial barrier dysfunction, yet reliable epithelial-derived diagnostic biomarkers remain elusive.MethodsWe employed an integrative multi-omics approach, combining single-cell RNA sequencing (scRNA-seq) and bulk transcriptomics from public datasets. Epithelial cell-specific signatures were identified and…