AZoLifeSciences - The A to Z of Life Sciences

Inside every cell, thousands of proteins must reach the right place at the right time. Helping coordinate this complex logistics network are centriolar satellites-tiny, membrane-less organelles that play important roles in protein trafficking, cell division, and the formation of cilia.

Understanding how molecular changes shape brain function and disease requires more than measuring genes in bulk tissue.

A two-headed molecule designed by Stanford Medicine researchers hijacks one of the most common protein drivers of B-cell lymphoma, flipping it from its role as a promoter of cell growth into an arbiter of cell death.

Researchers at the University of Cologne, University Hospital Cologne, and the Max Planck Institute for Metabolism Research have developed a method that, for the first time, enables damage to individual cells to be precisely quantified.

Precise activation of tens of thousands of genes is critical for healthy development and growth. Specialized segments of our DNA are responsible for carefully orchestrating genetic sequences that result in the production of enzymes, hormones, proteins and other crucial components underlying cell structure and function.

Stopping tumor growth is only half the battle. Rather than kill tumor cells, many cancer therapies can only push them into cellular senescence, a state in which cells stop dividing but do not die. These "undead" cells will continue to release signals that reshape the tumor environment.

Cancer patients often face more than the disease itself. Their treatment is frequently complicated by infections and other health conditions, meaning they may need to take several different medications at once.

A human, an octopus, and a coral could hardly look more different - yet deep inside their cells, their chromosomes still carry recognizable pieces of a genome inherited from an animal ancestor that lived more than 600 million years ago.

Biology doesn’t happen at one scale. Molecular interactions unfold in milliseconds and nanometers, while disease-associated change such as in Alzheimer’s spreads across millimeters of brain tissue.

In a new study, scientists from Johns Hopkins Medicine report that an experimental mRNA-based platform has the potential to help deliver next-generation mRNA therapeutics, including vaccines fighting against infectious disease, cancer and autoimmune conditions, faster and more efficiently than the industry standard.

Selenosugars are the major urinary metabolites responsible for the physiological excretion of selenium. Understanding selenium metabolism relies on accurately detecting and identifying selenosugars.

If you want to describe a particular color, you could look to the Pantone color wheel to find its exact hue, saturation and brightness, and how it compares to other colors. But nothing like that has existed for complex odors.

The human brain is often described as one of the most complex structures in biology, and much of its power comes from how it's organized.

All living things have a fleet of tiny copy machines that turn instructions from DNA into RNA, the molecules responsible for helping build proteins that keep organisms alive.

Drug-target interaction prediction can help researchers explain mechanisms of action, identify candidate targets, reposition existing medicines and prioritize compounds before costly laboratory work.

Whether you are characterizing cell state transitions, assessing organelle integrity, or building a multiplex immunofluorescence (IF) assay, you need reliable structural markers for your imaging.

In people with type 1 diabetes, the immune system mistakenly destroys the pancreatic beta cells responsible for producing insulin. Patients therefore require lifelong insulin therapy to regulate their blood glucose levels.

Researchers at Karolinska Institutet and Stockholm University have developed a new tool that estimates a cell's biological age by analysing its gene activity.

Most people carry the fungus Cryptococcus neoformans in their lungs for life and never know it, held in check by the immune system.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans-with 5,000 more diagnosed each year.