neurodegeneration

Scientists have taken a major step toward safely freezing and reviving brain tissue by preventing the microscopic damage normally caused by ice crystals. What if living tissue could be frozen for years, or even decades, and later revived without losing its function? Scientists searching for ways to make this possible have turned to an unlikely [...]

Obesity may worsen Alzheimer’s disease through fat molecules that send harmful signals to the brain, but targeting those molecules could offer a new path for intervention. Alzheimer’s disease is often viewed as a disorder that begins and ends in the brain. But growing evidence suggests the disease may also be shaped by what happens throughout [...]

Neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and stroke, remain major causes of global disability and mortality, with limited neuroprotective therapies available. Traditional Chinese medicine (TCM) offers multi-target therapeutic potential, but its mechanistic complexity requires systematic investigation using appropriate model systems. Zebrafish (Danio rerio) has e…

Scientific Reports, Published online: 25 May 2026; doi:10.1038/s41598-026-43151-1 Stabilizing fractional dynamical networks suppresses epileptic seizures

Scientific Reports, Published online: 24 May 2026; doi:10.1038/s41598-026-54619-5 Photothrombotic and middle cerebral artery occlusion models produce distinct neurovascular injury and sex-dependent outcomes

Risk of CTE in men’s sports has been widely studied, but female brains are softer and more vulnerable Cleo Pallister-Turley, a back for Cardiff university’s women’s rugby team, winces as she recalls two major concussions from playing rugby. “Girls ask me, ‘aren’t you worried about getting injured?’,” the biomedical sciences student said. “I enjoy the physicality and the intensity. For me, no othe…

Nature Human Behaviour, Published online: 19 May 2026; doi:10.1038/s41562-026-02468-7 Ageing impairs strategic re-aiming but enhances implicit recalibration during sensorimotor learning. The strategic deficit probably reflects reduced memory caching, whereas the implicit enhancement is linked to altered multisensory integration.

Scientists around the world have been searching for better ways to treat Alzheimer’s disease, a condition that slowly destroys memory and thinking ability. Millions of families are affected by the disease, and the number of cases is expected to rise as populations continue to age. Alzheimer’s disease is often linked to abnormal protein buildup in […] The post Scientists use the brain’s own cleani…

Abstract Background Ventriculo-peritoneal shunt insertion is an age-long and yet persistent procedure employed for the management of hydrocephalus in children. Although, the concerns of foreign body implantation and possible complications, is gaining attention, many surgeons continue to use ventriculo-peritoneal shunt to surgically treat hydrocephalus. In low-resource settings with limited or una…

Motor neuron disease (MND) is marked by progressive neurodegeneration in which presynaptic Ca2+-handling and mitochondrial metabolism are thought to be vulnerable, but direct functional studies in human brain are scarce because most material is frozen long-term. Here, we show that synaptosomes isolated from paired fresh and experimentally frozen mouse cortex, and from cryopreserved human motor co…

Abstract Background and Objectives: Friedreich ataxia (FA) causes progressive impairment of communication due to gradual deterioration of speech, associated with impaired hearing, socio-cognitive and language skills. There is an urgent need to investigate the impact of this multiparametric alteration on patients’ lives. Therefore, the COMunication and ATAXia measure (COMATAX) was developed and va…

Abstract Background External ventricular drainage (EVD)-associated ventriculitis is a serious complication in neurocritical care. Diagnostic uncertainty and heterogeneous infection prevention and control (IPC) practices may contribute to variable ventriculitis rates and potentially avoidable antibiotic exposure. We evaluated the impact of implementing an interdisciplinary standard operating proce…

A new study led by a team from the University of Ottawa takes a major step forward in understanding how a heart attack can dramatically reshape brain function and trigger neurological effects, from depression and anxiety to different types of cognitive decline.

IntroductionPrevious Western studies have shown an association between neurodegenerative plasma biomarkers and geriatric depression. However, few studies have examined this relationship in sub-Saharan African countries. This article examines this association in older adults with or without clinical dementia in Kinshasa, Democratic Republic of Congo.MethodsThis cross-sectional study included eight…

Many people notice that their handwriting changes as they grow older. Writing may become slower, shakier, less organized, or harder to read. Most people think these changes are simply a normal part of aging. However, scientists are now discovering that handwriting may reveal much more about brain health than previously believed. A new study published […] The post Your handwriting could reveal ear…

BackgroundWolfram syndrome is a rare autosomal recessive disorder characterized by antibody-negative early-onset diabetes mellitus, optic atrophy, sensorineural hearing loss, arginine-vasopressin deficiency, and progressive neurodegeneration of the brainstem and cerebellum. It is caused primarily by pathogenic variants in the WFS1 gene, which encodes a transmembrane endoplasmic reticulum–resident…

Studies of Alzheimer’s disease (AD) have long been dominated by the amyloid cascade hypothesis, although mounting evidence suggests that amyloid-β (Aβ) deposition might be a late downstream event, rather than the initiating trigger of AD. Here, I propose a unifying Triple-Hit Hypothesis in which AD develops through a sequential interaction among three causative processes that have been individual…