neurodegeneration

A large study of older adults in China suggests that depression can lead to a decline in memory and thinking skills by causing people to withdraw from their social circles, highlighting a potential pathway to protect aging brains.

Researchers at UT Southwestern Medical Center studying Parkinson's disease have discovered a previously unrecognized sequence of abnormal activity across multiple regions of the brain, providing a new level of understanding that could improve treatment options.

BackgroundPost-stroke depression (PSD) is the most common neuropsychiatric complication following stroke. Puerarin (PU), the principal bioactive compound extracted from the medicinal and edible plant Pueraria lobata, has shown beneficial therapeutic effects in both depression and stroke. However, the therapeutic effect of PU on PSD and its underlying mechanisms remain unclear. This study investig…

Most of our brain's 100 billion neurons are created before we're born, but the trickle of neurons created in the adult brain hippocampus could be instrumental in preventing depression, suggest findings from a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by debilitating motor impairment, cognitive decline, and a substantial reduction in patient quality of life. While pharmacological treatments and standard physiotherapy provide essential symptomatic relief, they often offer only transient benefits. Consequently, there is growing interest in non-pharmacological inte…

Nature Medicine, Published online: 21 August 2026; doi:10.1038/s41591-026-04571-8 The largest multiomic atlas of the adult human hippocampus identifies disrupted neurogenesis, gene regulation and neural circuits in major depressive disorder, revealing molecular pathways and potential therapeutic targets related to stress, cellular aging and neuroplasticity.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans-with 5,000 more diagnosed each year.

A new study from the Yale Department of Pathology and Department of Ophthalmology and Visual Sciences suggests that immune cells that live at the borders of the brain are shaped not only by inflammatory signals, but also by the physical environment of the tissues they inhabit.

This perspective provides an overview of the growing literature on the role of the immune system in driving neurodegeneration and argues that restoring neuroimmune dialogue, rather than simply clearing protein aggregates, is the next frontier for therapeutic development.

Research using human brain organoids onboard the International Space Station International Space Station (ISS) helped lead to the clinical trial of a potential therapy for Rett syndrome, a debilitating neurological disorder in children.

The development of Alzheimer disease (AD) involves a cluster of pathogenic processes, including amyloid-beta (Aβ) deposition, tau-mediated neurodegeneration, chronic neuroinflammation, oxidative stress (OS), metabolic dysregulation, and disruption of circadian rhythms. Nuclear hormone receptor, Retinoic Acid-Related Orphan Receptor Alpha (RORα) was shown to regulate multiple neuroprotective pathw…

Specialized brain scans reveal that schizophrenia is linked to widespread loss of the synapses that connect brain cells, with the left side of the brain hit especially hard. The damage follows a surprisingly organized pattern tied to the brain’s chemistry and wiring. Researchers also identified a left frontal region that may serve as a starting point for the loss.

IntroductionExercise and metabolic health are key modulators of brain plasticity, influencing processes such as angiogenesis and neurogenesis.MethodsThe present study investigated the effects of eight weeks of high-intensity interval training on capillary density and neurogenesis in the hippocampus of diabetic (db/db) and non-diabetic (db/+) mice, using established markers for capillaries (collag…

Author: Dr. Jacque Pak Kan Ip Affiliation: School of Biomedical Sciences & Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong SAR, China Key themes: Hong Kong’s contribution to the journal Neuroscience • Strategic regional and global integration • Focus on aging and neurodegeneration • Generational continuity of pioneering researchers   Reflection […] The post 50 R…