neurodegeneration

Huntington disease is a rare, inherited brain disorder that progressively destroys nerve cells, leading to worsening movement, cognitive and psychiatric symptoms.

It is known that heatwaves promote the development of neurological events such as strokes. In addition, people with neurological diseases such as MS, Parkinson's, migraines or dementia are a particularly vulnerable group; rising temperatures lead to a noticeable worsening of their condition. The Ger...

Nature Neuroscience, Published online: 08 June 2026; doi:10.1038/s41593-026-02318-9 Driessen et al. show that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex.

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For over a century, neurodegenerative diseases like Alzheimer’s and Parkinson’s disease have been considered protein disorders, characterised by the accumulation of amyloid-beta plaques, tau tangles, and Lewy bodies. Research and drug development followed the same logic: target the proteins, slow the disease. The results, after decades of trials and considerable investment, have been largely disa…

The mouse is wide awake. It is sniffing at a new object dropped into its cage, paws busy, whiskers going, doing all the things a curious and thoroughly sleep-deprived mouse does. And yet, o New! Sign up for our email newsletter on Substack. New! Sign up for our email newsletter on Substack. The mouse is wide awake. It is sniffing at a new object dropped into its cage, paws busy, whiskers going, d…

By inducing specific patterns of activity in small portions of the brain in awake mice, researchers supported by the National Institutes of Health (NIH) have triggered a recalibration of neural connections that normally only occurs during sleep.

Alzheimer’s disease is the most common cause of dementia, affecting millions of people around the world. It slowly destroys memory, thinking skills, and the ability to carry out everyday activities. Despite decades of research, scientists are still trying to understand exactly why the disease develops and how it progresses over time. One area receiving increasing […] The post A Hidden Brain Switc…

Scientific Reports, Published online: 08 June 2026; doi:10.1038/s41598-026-55387-y Intelligent Parkinson’s disease identification via Residual-Shuffle Network optimized by Improved Dandelion Optimizer

Researchers from ETH Zurich have developed an active ingredient that slows down the progression of typical Alzheimer’s symptoms in mice. This new substance protects nerve cells and could in future alleviate the suffering of Alzheimer’s patients. The active ingredient also shows anti-aging effects.

A single snapshot of brain volume forecasts future memory decline better than tracking brain shrinkage over time. This approach highlights the brain's structural reserve, offering a practical tool to identify those at highest risk for developing clinical dementia.

A massive analysis of brain scans suggests that reduced gray matter volume and white matter integrity mediate aggressive behavior in patients with schizophrenia, providing new insights into the biology of violence.

A new study suggests that subtle changes in the brain’s immune cells could help explain why some people remain mentally sharp despite Alzheimer’s pathology. For decades, Alzheimer’s research has focused on the buildup of amyloid plaques and tau tangles, the two hallmark features of the disease. Yet a puzzling reality has continued to challenge scientists: [...]

A daytime nap feels like a small mercy. Twenty minutes on the sofa, a quick reset, and you wake sharper than before. Yet of all the things 23,000 middle-aged adults told researchers about how they slept, regular napping turned out to be the habit most stubbornly tied to a particular kind of wear and tear deep inside the brain. Not snoring. Not nodding off at your desk. Napping. The finding comes …

Nature Communications, Published online: 05 June 2026; doi:10.1038/s41467-026-73347-y Intracranial tracking of 20 people living in a hospital showed that brain activity shifts via chaotic bursts when people transition between behaviors. A stabilizing manifold steadied these bursts but was impaired by sleep deprivation, increasing chaos.

How we sleep may have lasting impacts for our brain health as we age. A new University of Arizona study has found that several common sleep behaviors may be linked to signs of brain aging.

The death of a six-year-old inspired a UW–Madison researcher to investigate a rare brain cancer.

IntroductionChronic neuroinflammation disrupts oligodendrocyte differentiation and limits effective remyelination across multiple neurological disorders. Among the molecular regulators integrating inflammatory cues with oligodendrocyte maturation, G protein-coupled receptor 17 (GPR17) has emerged as a critical checkpoint. Physiologically, GPR17 expression is low in early oligodendrocyte precursor…

Parkinson’s disease is one of the most common brain disorders in the world, affecting an estimated 8 million people. The condition mainly affects movement and often develops slowly over many years. People with Parkinson’s may experience trembling hands, muscle stiffness, slow movements, balance problems, and difficulty walking. As the disease progresses, it can also affect […] The post Could Gut …

We propose that current Neuroscience approaches can benefit from further integrating morphodynamics across different scales of brain organization and neural network emergent functions in complex systems. While emergence in neuroscience is commonly addressed at higher organizational levels, here we consider neuronal morphology itself as an emergent level of organization. Progressing from form-base…