neurogenetics

Kauê M. Costa was a Ph.D. student in Germany trying to understand how amphetamines cause hyperactivity when he noticed his mice were acting weird. The mice were genetically engineered to help researchers study dopamine in the brain, and they were unusually hyperactive. The amphetamines they were taking calmed the females but not the males. The mice were learning differently based on sex, and this…

One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human.

One of the symptoms of schizophrenia is difficulty incorporating new information about the world. This can lead people with schizophrenia to struggle with making decisions and, eventually, to lose touch with reality. MIT neuroscientists have now identified a gene mutation that appears to give rise to this type of difficulty. In a study of mice, […]

By combining connectome data with spatial gene expression maps, scientists have discovered how chemical gradients guide the wiring of the entire brain. The findings offer new ways to understand brain development and neurodevelopmental disorders.

Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74228-0 Neural mechanisms underlying rhythmic motor behaviors are not fully understood. Here authors propose a theory of how the nervous system generates and controls walking, which entails a spatial layout of spinal nerve cells that form longitudinal connectivity patterns of a ‘Mexican hat’, i.e. local excitation and l…

Variants in the DHDDS gene cause a severe neurodegenerative condition, characterized by tremors, seizures, coordination and learning difficulties, usually manifesting in early childhood. This Parkinson's-like condition is extremely rare, and until recently, parents were told that there was nothing that could be done to slow down its progression.

Researchers developed FEDE, a high-fidelity digital brain twin pipeline that combines MRI-derived anatomy with biophysical modeling to reconstruct brain structure and simulate EEG activity. In a single toddler with autism spectrum disorder, the model closely reproduced recorded brain activity and suggested possible patient-specific alterations in neural noise and excitatory-inhibitory balance.

Hi everyone, I've been hacking on a local personal memory system called Hillock . Honestly, it's very much a work in progress and it isn't some flawless breakthrough, but I wanted to see if we could build a lightweight, completely offline memory layer for local LLMs without the overhead of running a heavy neural vector database or wasting precious VRAM. The project is named after the biological A…

Further reading. https://academic.oup.com/brain/advanc… https://doi.org/10.1093/brain/awae150 #organoids #sciencenews #brainorganoids #sentience #biocomputers #conciousness

Autism is a complex condition that can affect different people in very different ways. While...

Scientists have created the first complete brain-to-body wiring map of a fruit fly, revealing that complex behavior may arise from distributed neural teamwork rather than a central controller. A large international research team led by labs at Harvard Medical School and Princeton University has reached a major neuroscience milestone: a complete wiring diagram of every [...]

For the first time, researchers connected a person's overall genetic risk for ADHD to specific irregularities in how their brain coordinates attention. The finding bridges the gap between inherited DNA and observable neurological changes.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74320-5 Spatial and single-cell transcriptomics of patient-derived brain organoids reveal disrupted progenitor–neuron organization and local neuronal disarray, implicating spatially mosaic pathogenesis in autism heterogeneity.

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The field of human adult neurogenesis has been controversial despite mounting evidence. This Perspective proposes moving beyond debating the existence of adult neurogenesis, and towards discovering strategies to harness endogenous stem cell potential for resilience against cognitive aging.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74274-8 Humans show reproducible sex differences in regional cortical volume, area and thickness controlling for overall brain size. These regions are enriched for effects of potentially causal sex chromosomal and gonadal influences on cortical anatomy.

Midhila Jayan, National Law School of India University ABSTRACT Neuroscience, as a field, by analysing the structure and function of the brain, provides insight that changes the approach to juvenile justice in India. Currently, fixed age thresholds are used in India to assess the responsibility of adolescents involved in cases of a criminal nature. These fixed measures of assessing maturity based…

Mutations in human LIS1 cause lissencephaly, a severe developmental brain malformation. Although most studies focus on development, LIS1 is also expressed in adult mouse tissues. We previously induced LIS1 knock-out (iKO) in adult mice using a Cre-Lox approach with an actin promoter driving CreERT2 expression. This proved to be rapidly lethal, with evidence pointing toward […]

Nature Neuroscience, Published online: 12 June 2026; doi:10.1038/s41593-026-02330-z Striatal direct and indirect pathways jointly control how many actions are performed during counting, and how animals move toward specific goals. These pathways implement a push–pull controller for discrete action counting as well as continuous movement control.