neurogenetics

Hi everyone, I've been hacking on a local personal memory system called Hillock . Honestly, it's very much a work in progress and it isn't some flawless breakthrough, but I wanted to see if we could build a lightweight, completely offline memory layer for local LLMs without the overhead of running a heavy neural vector database or wasting precious VRAM. The project is named after the biological A…

Further reading. https://academic.oup.com/brain/advanc… https://doi.org/10.1093/brain/awae150 #organoids #sciencenews #brainorganoids #sentience #biocomputers #conciousness

Autism is a complex condition that can affect different people in very different ways. While...

Scientists have created the first complete brain-to-body wiring map of a fruit fly, revealing that complex behavior may arise from distributed neural teamwork rather than a central controller. A large international research team led by labs at Harvard Medical School and Princeton University has reached a major neuroscience milestone: a complete wiring diagram of every [...]

For the first time, researchers connected a person's overall genetic risk for ADHD to specific irregularities in how their brain coordinates attention. The finding bridges the gap between inherited DNA and observable neurological changes.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74320-5 Spatial and single-cell transcriptomics of patient-derived brain organoids reveal disrupted progenitor–neuron organization and local neuronal disarray, implicating spatially mosaic pathogenesis in autism heterogeneity.

Support this channel on Patreon to help me make this a full time job: / whatdamath (Unreleased videos, extra footage, DMs, no ads) Alternatively, PayPal donations can be sent here: http://paypal.me/whatdamath. Get a Wonderful Person Tee: https://teespring.com/stores/whatdamath. More cool designs are on Amazon: https://amzn.to/3QFIrFX Hello and welcome! My name is Anton and in this video, […]

The field of human adult neurogenesis has been controversial despite mounting evidence. This Perspective proposes moving beyond debating the existence of adult neurogenesis, and towards discovering strategies to harness endogenous stem cell potential for resilience against cognitive aging.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74274-8 Humans show reproducible sex differences in regional cortical volume, area and thickness controlling for overall brain size. These regions are enriched for effects of potentially causal sex chromosomal and gonadal influences on cortical anatomy.

Midhila Jayan, National Law School of India University ABSTRACT Neuroscience, as a field, by analysing the structure and function of the brain, provides insight that changes the approach to juvenile justice in India. Currently, fixed age thresholds are used in India to assess the responsibility of adolescents involved in cases of a criminal nature. These fixed measures of assessing maturity based…

Mutations in human LIS1 cause lissencephaly, a severe developmental brain malformation. Although most studies focus on development, LIS1 is also expressed in adult mouse tissues. We previously induced LIS1 knock-out (iKO) in adult mice using a Cre-Lox approach with an actin promoter driving CreERT2 expression. This proved to be rapidly lethal, with evidence pointing toward […]

Nature Neuroscience, Published online: 12 June 2026; doi:10.1038/s41593-026-02330-z Striatal direct and indirect pathways jointly control how many actions are performed during counting, and how animals move toward specific goals. These pathways implement a push–pull controller for discrete action counting as well as continuous movement control.

They weren’t just tuning the strength of the incoming signals (the synapses); they were actually training the neuron on *where* those signals should land on its branchy “tree” to get the best results. Cortical pyramidal neurons possess elaborate dendritic trees with diverse nonlinear membrane conductances and thousands of plastic synapses, suggesting substantial computational capabilities at [&#8…

A recent EMBO workshop brought together researchers who are expanding our understanding of how layers of genetic and epigenetic regulation underlie critical brain functions.

A new study suggests that variables linked to socioeconomic status (SES) – such as increased stress and reduced sleep – have strong relationships to brain structure and function in children.

People with traits like narcissism and psychopathy show shared and distinct physical differences in brain regions linked to empathy. These anatomical variations suggest abrasive personality traits carry unique, identifiable signatures in the structure of the human brain.

A study of more than 2,300 9- to 10-year-olds found that socioeconomic factors explained most differences in the preteens' brain development.

Data from animal studies point to a troubling possibility: Caffeine may alter brain development.

Author: Dr. Dipesh Chaudhury Affiliations: New York University Abu Dhabi (NYUAD) Key themes: • United Arab Emirates (UAE) • Neuroscience research • Mental health • Brain development • Neural circuits • Human cognition • Brain plasticity • Memory • Behaviour • Gene regulation • Sleep and circadian rhythms • Scientific growth Reflection #22 The United […] The post 50 Reflections on Neuroscience – #…

Slime molds are slippery, nebulous beings. They're not true molds. They're not even fungi. For...