neurogenetics

Understanding how molecular changes shape brain function and disease requires more than measuring genes in bulk tissue.

Findings from a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons suggest that the trickle of neurons created in the adult hippocampus could be instrumental in preventing depression. Most of the brain’s 100 billion neurons are created before birth. Published in the journal Nature Medicine, the study shows for the […]

The mini-brains are full of surprises The post The Remarkable Lives of 5-Year-Old Brain Organoids appeared first on Nautilus .

Consciousness remains incompletely explained at the anatomical, biophysical, and functional levels. Although existing theories characterize key functional correlates of conscious experience—including global broadcasting, information integration, attentional selection, working-memory-based awareness, and electromagnetic field dynamics—none has yet identified a specific cellular mechanism embedded …

How does autism manifest in the brain? Researchers from the University of Southern Denmark and Odense University Hospital have investigated this question in a new study involving 60 adults.

Most of our brain's 100 billion neurons are created before we're born, but the trickle of neurons created in the adult brain hippocampus could be instrumental in preventing depression, suggest findings from a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

Researchers identified wake-activated neurons in the median raphe and anterior medial preoptic area that track sleep pressure and help regulate when and how deeply mice sleep. Manipulating these circuits altered NREM sleep, sleep-pressure accumulation, and rebound sleep, revealing key neural mechanisms underlying mammalian sleep homeostasis.

By using chemical signals to guide cells to adopt distinct regional identities, scientists created lab-grown human organoids that mimic early brain development and could illuminate how specialized brain areas emerge. The post Lab-Grown Neocortex Models Mimic Early Brain Organization appeared first on GEN - Genetic Engineering and Biotechnology News .

Neuropsychopharmacology, Published online: 19 August 2026; doi:10.1038/s41386-026-02525-9 Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice

Nature Reviews Neuroscience, Published online: 21 August 2026; doi:10.1038/s41583-026-01075-9 Early-life exposure to stressors can lead to increased stress susceptibility in later life, shown here to be mediated in mice by SETD7-mediated monomethylation of H3K4 in dopaminergic neurons of the ventral tegmental area.

Human brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, following human-specific endogenous programs, even outside the context of the organism.

Thirty years ago, an insight from a rare brain disease took Robert Darnell's career in an unexpected direction. He's still surprised by what he's learning.

Thirty years ago, an insight from a rare brain disease took Robert Darnell's career in an unexpected direction. He's still surprised by what he's learning.

Thirty years ago, an insight from a rare brain disease took Robert Darnell's career in an unexpected direction. He's still surprised by what he's learning.

Nature Reviews Neuroscience, Published online: 20 August 2026; doi:10.1038/s41583-026-01074-w Understanding how early life stress becomes biologically embedded remains a major challenge in neuroscience. In this Review, Maze and colleagues discuss recent advances in cell-type-specific epigenetic and transcriptional mechanisms underlying long-term stress susceptibility.

A study by the University of Eastern Finland revealed for the first time clear differences in the function and gene expression of microglial cells from patients with genetic and sporadic types of frontotemporal dementia.

The ALBA Network invites nominations for the 2027 ALBA-Elsevier Award Lecture. This award celebrates outstanding neuroscientists who are pushing the frontiers of brain research, championing diversity and equal opportunity in science. Candidates must have run their own lab for at least five years and be based in countries underrepresented in neuroscience publications and conferences. Non-eligible …

IntroductionExercise and metabolic health are key modulators of brain plasticity, influencing processes such as angiogenesis and neurogenesis.MethodsThe present study investigated the effects of eight weeks of high-intensity interval training on capillary density and neurogenesis in the hippocampus of diabetic (db/db) and non-diabetic (db/+) mice, using established markers for capillaries (collag…