immunology

A review finds increasing evidence that obesity and Alzheimer's disease (AD) are biologically linked. The researchers highlight shared early metabolic disruptions involving mitochondrial dysfunction, chronic inflammation and abnormal signaling from fat tissue, which can affect brain health long before symptoms appear. The research also points to the gut-brain axis as a contributor to neurodegener…

Intestinal ischemia/reperfusion (I/R) injury is a common pathophysiological phenomenon that is widely present in various primary intestinal diseases and systemic critical illnesses, potentially leading to multiple organ dysfunction and failure, with high morbidity and mortality.

Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72642-y Molecular characteristics of amniote lineages can inform evolutionary inference. Here, the authors present a single-cell RNA-sequencing atlas of the chicken, which is applied to compare immune cells of chicken, turtle, duck and human, determining similarities and distinctions across amniote immune system evolutio…

Nature Biomedical Engineering, Published online: 30 April 2026; doi:10.1038/s41551-026-01671-1 PRIME-In couples a prime edited donor template with either single or paired genomic nicks to enable precise integration of even large constructs into human cells, as exemplified by high-efficiency integration of a 3-kb CAR construct in T cells.

Nature, Published online: 05 May 2026; doi:10.1038/d41586-026-01443-6 Thymic health under the microscope

Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72791-0 Pre-existing hypoglycemia weakens the host’s interferon-based immune defense by downregulating the antiviral protein TRIM5 in the lung, thereby increasing the susceptibility to influenza infection.

A biopsy of a woman's cancer seems to have triggered an immune response against the tumour, putting her into remission

IntroductionAxillary bromhidrosis is characterized by excessive sweat gland activity and foul body odor, significantly affecting patients’ psychological well-being and social interactions.MethodsThis study recruited 30 axillary bromhidrosis patients and 30 healthy controls, collecting sweat and stool samples for microbiome analysis. Among the patients, 8 patients received microwave therapy, colle…

npj Vaccines, Published online: 04 May 2026; doi:10.1038/s41541-026-01453-5 Immunogenicity of PCV13 during Hospitalization soon after infection resolution: Vaccis study

Scientific Reports, Published online: 05 May 2026; doi:10.1038/s41598-026-49131-9 Involvement of autoantibodies against G protein-coupled receptors in post-COVID condition and Chronic Fatigue Syndrome

St. Jude Children's Research Hospital immunologist recognized for his contributions to advancing immunology and immunometabolism.

Research from Mayo Clinic is helping refine how multiple myeloma is diagnosed and treated, with findings that support more personalized therapies and identify promising immunotherapy strategies for aggressive forms of the disease.

Cedars-Sinai Health Sciences University investigators are bringing their stem cell expertise to a collaboration with two other academic medical centers with the goal of clarifying the connection between pesticide exposure and Parkinson's disease.

Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72395-8 This study identifies a mitochondrial protection pathway that safeguards mitochondrial DNA integrity and limits liver damage. Disrupting this pathway triggers inflammation and fibrosis, while restoring protection or inhibiting DNA sensing markedly ameliorates fatty liver disease.

BackgroundEndometriosis is a complex gynaecological disorder that affects 10%–15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction is implicated in endometriosis pathogenesis, the causal relationships between mitochondrial genes and endometriosis remain unclear. This study aims to elucidate these relationships…

Traumatic experiences can cause memory problems, and estrogen may be a key factor that shapes the brain's resilience against such stressors, a mouse study finds.

Corewell Health(tm) is now offering Tumor-Infiltrating Lymphocyte (TIL) therapy at Corewell Health William Beaumont University Hospital in Royal Oak, becoming one of the first Michigan health systems to provide this newly approved cellular treatment for advanced melanoma.

Akkermansia muciniphila's impact on immunity and pregnancy outcomes underscores its promise as a probiotic, with implications for infectious disease treatment.

Somewhere in your bloodstream, a type of white blood cell is quietly doing double duty. Monocytes are foot soldiers of the immune system, dispatched to sites of infection and inflammation with workaday efficiency. But these cells are also, it turns out, keeping a kind of biological diary, accumulating chemical modifications to their DNA that record how fast they are aging. And a new study suggest…