immunology

Porcine circovirus type 2 (PCV2) and type 3 (PCV3) pose severe threats to swine health worldwide. PCV2 field strains continuously mutate with the co-circulation of multiple genotypes, resulting in potential immune escape from existing vaccines. PCV3, an emerging pathogen, currently has no commercially available vaccines. Clinically, PCV2-PCV3 co-infection is prevalent, thus highlighting an urgent…

Case presentationA 4-year-old spayed female mixed breed dog presented for chronic upper airway noises and dysphagia. The dog presented for inspiratory stridor and expiratory stertor. Serum creatine kinase activity was 3,296 IU/L, and cholesterol and triglyceride levels were elevated at 353 mg/dL and 201 mg/dL, respectively. In-house thyroxine levels were below the reference range, prompting the s…

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74021-z The study shows that disruption of calcium homeostasis triggers the aberrant accumulation of S100A6 in the cytoplasm, thereby promoting Hutchinson-Gilford Progeria Syndrome (HGPS) and natural aging. Mianserin was found to effectively retard the aging process and significantly extend the lifespan of both progeroi…

A new study suggests that subtle changes in the brain’s immune cells could help explain why some people remain mentally sharp despite Alzheimer’s pathology. For decades, Alzheimer’s research has focused on the buildup of amyloid plaques and tau tangles, the two hallmark features of the disease. Yet a puzzling reality has continued to challenge scientists: [...]

The UCLA study, conducted in mouse models and human cells and published in iScience, shows that dendritic cells -- the immune cells that direct killer T cells to attack cancer -- ramp up their intake of creatine inside tumors and depend on it to function effectively in this nutrient-poor environment.

Why studying how the immune system evolves could teach us much about evolution itself

Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, supercharges a critical class of immune cells that activate and prepare the body's key cancer-fighters, according to new UCLA research.

Nature Medicine, Published online: 05 June 2026; doi:10.1038/d41591-026-00030-6 From artificial intelligence-enhanced scans to drugs that target the immune system, inflammation is emerging as a key driver of cardiovascular risk — and clinicians are learning to detect and treat it.

npj Vaccines, Published online: 05 June 2026; doi:10.1038/s41541-026-01499-5 Response to vaccination and immune status after intrauterine exposure to immunomodulating drugs for maternal IBD

npj Vaccines, Published online: 05 June 2026; doi:10.1038/s41541-026-01498-6 Genetically diverse CC and DO mouse models enable comprehensive assessments of novel tuberculosis vaccines

Malignant tumors remain a major threat to human health, with conventional therapies and first-generation immune checkpoint inhibitors (ICIs) facing limitations like drug resistance and low response rates.

In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (Leqembi, from Biogen) and donanemab (KisunlaTM, from Eli Lilly and Company), both based on immunotherapy (the use of molecules from the immune system to treat diseases).

Researchers found that, although antibody evolution is highly chaotic at the level of individual cells, germinal centers reliably produce stronger antibodies through repeated rounds of mutation and selection that are only slightly biased toward success.

A shrimp vaccine for commercial use could protect the environment and prove vaccines aren’t just for vertebrates.

Scientific Data, Published online: 05 June 2026; doi:10.1038/s41597-026-07489-5 Single cell transcriptome profiling of peripheral blood mononuclear cells in Guillain–Barré syndrome patients

The management of psoriatic arthritis is increasingly focused on the early identification of clinical, immunological, and tissue-based phenotypes predictive of therapeutic response.

BackgroundThe effects of the gut microbiota on the regulation of host physiology have recently garnered considerable attention, particularly in metabolism and the immune system. However, the role of the gut microbiota in viral myocarditis (VMC) remains to be fully elucidated.MethodsBalb/c mice were injected with CVB3 to induce VMC. VMC mice were treated with fecal microbiota transplantation (FMT)…