aging

“Longevity” — a buzzy catchall for the quest for a longer life — is having a moment. Tech titans like Peter Thiel, Mark Zuckerberg, and Jeff Bezos are spending billions to fund research into how to slow aging. Celebrities like Gwyneth Paltrow and Hailey Bieber are touting peptide use. And the world’s most powerful authoritarian […]

ObjectiveTo investigate whether Gastrodin (Gas) attenuates doxorubicin (Dox)-induced cardiomyocyte senescence and apoptosis by regulating the AMPK/mTOR/4EBP1 signaling pathway and autophagy-related processes.MethodsA Dox-induced senescence model was established in H9c2 cardiomyocytes, and different concentrations of Gas (0.5 mM and 1 mM) were used for intervention. Senescence phenotypes were eval…

Are we on the verge of outrunning aging entirely? Renowned futurist and inventor Ray Kurzweil shares his data-driven predictions on the exponential trajectory of artificial intelligence and its near-term impact on human health. Speaking to a Cosmos conference from his studio, Kurzweil charts the predictable, uninterrupted 80-year history of computing power from early wartime codebreaking […]

The university president and biomedical scientist talks about the hope and doubt in U.S. science today

Cynthia Kenyon is vice president of aging research at Calico Labs. She is an emeritus professor at the University of California, San Francisco, where her lab’s discovery of genes that affect the aging process in a small roundworm called Caenorhabditis elegans helped spawned a groundswell of research around the molecular determinants of aging. [This interview was edited for length and clarity.] Ho…

The biological age of individual cell types can be evaluated using plasma proteomics, revealing diverse aging profiles across more than 40 cell types and links between the accelerated aging of specific cell types and disease.

Aging involves a decline in physiological functions and increased disease susceptibility, with the immune system playing a pivotal role. Recent research reveals that nonimmune structural cells, such as fibroblasts, epithelial cells, and neurons, develop immune-like properties crucial for stress response and tissue integrity. However, with aging, these organized, nonimmune cells in multicellular o…

Understanding why some people stay healthy without developing disease until late in life (have an increased healthspan), whereas others become infirm at a much younger age has important implications for the health of today's ageing population.

A UK cost-of-illness projection estimates that direct NHS dental treatment costs for adult caries and periodontal disease will rise by 20%, from £4.42 billion in 2020 to £5.30 billion by 2050. The burden shifts strongly toward older adults and severe disease, supporting prevention and earlier intervention as NHS dental planning priorities.

Immorta Bio President Thomas Ichim and TAM Global's Chief Scientific Officer Francesco M. Marincola today announced a landmark preclinical breakthrough demonstrating a more than 70% increase in lifespan in mice.

(MIT Technology Review) – Earlier this week, Life Biosciences, a biotech company focused on reversing age-related diseases, announced that it had dosed its first volunteer. A person with glaucoma has had an experimental treatment injected straight into their eyeball. The … Read More

A target trial emulation of older adults entering skilled-nursing facilities found that those who received the recombinant shingles vaccine (RZV) had a lower risk of developing dementia over the following four years compared with those who were not vaccinated.

Scientists have long known that being obese increases the risk of dementia and Alzheimer's disease. What remains unclear is how that risk develops in the brain.

I turned 48 this week, which meant it was time for my annual physical. After the usual battery of questions from my doctor — How much did I drink? Was I exercising? How was I sleeping? — it was my turn to ask a question. I had one prepared: Should I get the shingles vaccine? […]

We over-5os should worry less about our crepe necks and sunspots and more about our listening skills – and the pettiness we bring to social media When I was young, there was a huge list of things you shouldn’t do, or specifically wear, over the age of 30; there were fewer explicit rules about what you should and shouldn’t wear over the age of 50, but they were all implied by the fact that it was …

An increasing number of people are finding trail running relatively late in life – and they’re reaping the health benefits Earlier this year, 62-year-old Karla Wagner placed second in the 100-mile division of the Grandmaster Ultras, an Arizona trail-running event designed for 50-and-over runners in the age group known as “grandmaster”. For most of her adult life, Wagner, who is from Lander, Wyomi…

Because glucosamine is widely available and frequently used by older adults to support joint health, the researchers wanted to determine whether it could influence Alzheimer’s disease and related dementias (ADRD). Working with collaborators Yi Guo, Ph.D., and Jiang Bian, Ph.D., the team used artificial intelligence to analyze deidentified UF Health records collected between 2012 and […]

A new study of retired athletes found that repetitive head trauma can lead to a "leaky" blood-brain barrier. This long-lasting damage allows immune cells to enter the brain, causing persistent inflammation and accelerating cognitive decline.

A large-scale study suggests that men with higher levels of the amino acid tyrosine may have shorter lifespans, potentially losing close to a year of life expectancy. The finding is especially intriguing because tyrosine is commonly associated with brain health and is often used in supplements aimed at boosting focus and performance.