aging

Targeting senescent cells with dasatinib-quercetin preserves disc structure and modulates degeneration-associated pathways in a mouse model.

Scientists have long known that conditions such as chronic stress, depression, heart disease, aging, and poor sleep are linked to a higher risk of dementia. However, researchers have struggled to fully understand why these very different health problems all seem connected to memory loss and brain decline later in life. Now, a new review article […] The post Why Poor Sleep May Raise the Risk of De…

High blood pressure is one of the world’s most common health problems. Millions of people live with it every day, often without noticing symptoms until serious damage has already occurred. Over time, high blood pressure can place enormous stress on blood vessels, the heart, and the brain. This increases the risk of dangerous conditions such […] The post Hidden Blood Vessel ‘Pressure Sensor’ May P…

IntroductionFamily caregivers of persons living with dementia experience high stress, elevated rates of depression and anxiety, and an increased risk of cognitive decline compared to non-caregivers. Applications of telehealth interventions in the field of aging and geriatrics can overcome geographic and logistical barriers in the delivery of education and lifestyle support. We report preliminary …

IntroductionOxidative stress-mediated retinal pigment epithelial (RPE) cell injury is a key pathological feature of age-related macular degeneration (AMD). Ferroptosis—an iron-dependent form of regulated cell death driven by lipid peroxidation—has been increasingly identified as a critical executor of RPE degeneration and a key pathogenic mechanism in AMD. This study aimed to investigate the mech…

A long-running study suggests that one of the simplest ways to support healthy aging may also be one of the most effective: eating slightly fewer calories. Search online, and you will find countless biohacking trends that promise healthier aging, from cold plunges and hyperbaric oxygen therapy to sleeping under red lights. But research from Tufts [...]

Live Science spoke with Alika Maunakea, an Native Hawaiian epigeneticist, about how epigenetics underpins health disparities between Native Hawaiians and others in Hawaii.

New research links trauma and frailty in aging, suggesting EMDR may improve both mental health and physical resilience in older adults.

Alzheimer’s disease has become one of the biggest health challenges facing older adults around the world. The disease slowly damages memory and thinking abilities, eventually making it difficult for people to recognize loved ones, communicate clearly, or care for themselves. Although both men and women can develop Alzheimer’s disease, women are affected much more often. […] The post Common health…

Alzheimer’s disease is one of the most feared health conditions, mainly because it affects memory, thinking, and independence. For many years, people believed that once the disease begins, it always gets worse at a steady pace. However, new research suggests that this belief may not be accurate. A study from the Keck School of Medicine […] The post Study finds three very different outcomes in ear…

As people grow older, it is common for memory and thinking skills to slowly become weaker over time. Many older adults may notice that they sometimes forget names, lose track of conversations, or take longer to make decisions. Scientists have long studied the many things that may affect brain health in old age, including exercise, […] The post Why Sudden Weight Changes in older people May Harm th…

A newly identified brain protein may play a major role in how the body ages. Researchers discovered that declining levels of Menin in the hypothalamus triggered inflammation, memory problems, bone loss, and other aging-related changes in mice. Restoring Menin reversed several of these effects, while a simple amino acid supplement called D-serine boosted cognition. The discovery opens a surprising…

It is a familiar food, but the latest evidence is prompting researchers to take a much closer look at its neurological effects.

Body weight may play a larger role in brain aging than previously understood. A number on the scale may say more about future brain health than previously recognized. New research from the University of Georgia suggests that higher body mass index, or BMI, may be linked to faster cognitive decline in older adults. The finding [...]

After 50, drinking problems can quietly emerge for the first time or return after years of control. Retirement, empty nests, and caregiving stress are often the hidden triggers.

As people grow older, their skin changes in many ways. It becomes thinner, weaker, and slower to repair itself after injury. Cuts, scrapes, burns, and surgical wounds often take much longer to heal in older adults than in younger people. Slow wound healing can increase the risk of infections, pain, and serious medical complications, especially […] The post New Drug Can Help Older Skin Stay Younge…

The 279-neuron connectome of Caenorhabditis elegans is the only complete neural wiring diagram available for any organism. We apply a differentiable causal discovery framework (CDSM) to analyze causal motifs, degree distributions, and Granger-predictive structure. The connectome contains 2213 chemical synapses and 1080 gap junctions (3257 unique connections). Causal motif counting reveals 10793 c…

BackgroundThis study aimed to identify joint longitudinal trajectories of physio-cognitive aging, determine the temporal precedence between physical and cognitive decline, and evaluate both the mediating role of life space constriction and the moderating effect of sensory impairment on incident dementia risk.MethodsUsing 8-year longitudinal data from the National Health and Aging Trends Study (NH…

A new study suggests that people who live past 100 may carry unique metabolic “fingerprints” in their blood that differ from typical aging patterns. What allows some people to live past 100 while staying remarkably healthy? Scientists have long known that exceptional longevity is shaped by a combination of genetics and lifestyle, from plant-rich diets [...]