autoimmunity

Nature Communications, Published online: 11 September 2026; doi:10.1038/s41467-026-77812-6 Anti-IgLON5 disease is a rare neuro-immunological disorder characterized by the production of autoantibodies against the cell adhesion molecule, IgLON5. Here, the authors examine the B cell receptor repertoire of an individual with this condition and present a cryo–electron microscopy structure of a patient…

[Proceedings of the National Academy of Sciences of the United States of America] Using three complementary mouse models reflecting distinct causes of lupus-like disease, scientists show that disruption of the SLC15A4–TASL complex broadly prevents autoimmunity, including immune activation, pathogenic B cell responses, and autoantibody production.

Investigators at Cedars-Sinai Health Sciences University used an experimental drug to reverse the effects of systemic sclerosis, a serious autoimmune disease. The study, conducted in a laboratory, was published in JCI Insight.

In autoimmune diseases, the immune system turns against the body through pathogenic high-affinity B cells or T cells, leading to severe organ damage. Multiple sclerosis (nervous system paralysis), type 1 diabetes (a strong risk factor for atherosclerosis requiring lifelong treatment) and rheumatoid arthritis (debilitating, excruciating joint deformities) are examples of clinically important autoi…

A new study in mice and patients shows that atherosclerosis meets the criteria for an autoimmune disease.

[Science Advances] Scientists demonstrated that HMGCS1, a cholesterol biosynthesis precursor enzyme, was highly induced by inflammatory cytokines and preferentially expressed by pathogenic T helper 17 cells in vitro and in vivo .

A massive analysis of immune cells in human tissue is yielding clues to the root cause of lung and autoimmune diseases.

A massive analysis of immune cells in human tissue is yielding clues to the root cause of lung and autoimmune diseases.

Nature Communications, Published online: 01 August 2026; doi:10.1038/s41467-026-76285-x APECED is a monogenic autoimmune disorder resulting from deleterious variants in the Autoimmune Regulator gene. Here, the authors report the cases of two patients with APECED in whom early intervention with the JAK1/2 inhibitor ruxolitinib prevented endocrine autoimmunity.

The Autoimmune Association is pleased to announce that registration is now open for the 5th Annual Autoimmune Community Summit, a free, fully virtual event designed to provide trusted information, practical tools, and meaningful support for people affected by autoimmune disease.

Sjögren's disease is a widespread chronic autoimmune disorder that attacks the body's own glands, yet its underlying disease mechanisms remain poorly understood.

The Colton Consortium for Autoimmunity today announced a new $15 million, three-year investment from the Colton Foundation to strengthen scientific leadership, expand faculty expertise, and advance collaborative research to accelerate breakthroughs in autoimmune disease across its partner institutions at New York University, Tel Aviv University, and Yale University.

The National Institutes of Health has launched its first agencywide Strategic Plan for Autoimmune Disease Research, a five-year initiative aimed at accelerating research into diseases that affect an estimated 50 million Americans and cost more than $100 billion annually.

Nature Communications, Published online: 12 May 2026; doi:10.1038/s41467-026-72975-8 CD4+ T cells are key drivers of chronic inflammation and immune-mediated tissue damage in autoimmune diseases. Here, the authors employ a mouse model of primary Sjögren disease (pSjD) and identify a subset of CD153+ CD4+ T cells responsible for inflammation and autoimmunity through interactions with CD30+ residen…

Ahead of World Lupus Day on May 10, new research from the Garvan Institute of Medical Research and UNSW Sydney helps explain why women are significantly more likely to be diagnosed with an autoimmune disease – a condition where the immune system misfires and mistakenly attacks the body's own healthy tissues.

Gillian Sandler is a life sciences investor who funds health tech companies with potential to help millions. But she began with a simple desire: Find a treatment for her sister’s autoimmune disease.