Nature Communications, Published online: 01 August 2026; doi:10.1038/s41467-026-76285-x APECED is a monogenic autoimmune disorder resulting from deleterious variants in the Autoimmune Regulator gene. Here, the authors report the cases of two patients with APECED in whom early intervention with the JAK1/2 inhibitor ruxolitinib prevented endocrine autoimmunity.