pharmacology

A naturally derived molecule shows promise in blocking critical behaviors that bacteria rely on to cause disease. Drug-resistant bacteria are quietly reshaping modern medicine, turning once-treatable infections into serious threats. Among the most concerning is Staphylococcus aureus, or “staph,” a microbe that commonly lives on the skin but can trigger dangerous infections if it enters [...]

IntroductionIn the treatment of schizophrenia, antipsychotics used during acute inpatient care must control acute symptoms while remaining sufficiently tolerable to support treatment beyond the acute phase. Brexpiprazole, a serotonin-dopamine activity modulator may be one such option; however, its real-world use and short-term continuation in acute inpatient settings remain insufficiently charact…

Drug development has always required decisions to be made in the face of uncertainty. Which dose should move forward? Which patient population is most appropriate? How should a study be designed to generate meaningful evidence?  For many years, those decisions have been shaped through a largely empirical and sequential process—where decisions are made primarily based on the data generated in the …

People who begin obesity treatment with glucagon-like peptide-1 receptor agonists (GLP-1s) and then undergo metabolic and bariatric surgery achieve substantially greater weight loss than with the medications alone, according to new research presented today at the annual meeting of the American Society for Metabolic and Bariatric Surgery.

Aannual report on the global effort to find a cure for Alzheimer's shows a 35% increase in the number of clinical trials and a 40% increase in therapies being tested since 2016. Significantly, 59 new trials entered the pipeline during the past year signaling an increased confidence in the ability to develop drugs to slow the loss of memory.

The rising concern of antimicrobial resistance, coupled with the continually challenging management of complicated diseases such as cancer, has provided momentum toward precision molecular medicine. This review provides an overview of bacteriophage enabled strategies encompassing both conventional antibacterial applications and advanced bioengineered delivery systems. Recent advances in phage the…

Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72816-8 Despite the proven therapeutic efficacy, CAR T cell treatment carries the risk of severe toxicities. How sex-associated differences affect therapy-associated toxicities is underexplored. Here, the authors conduct a retrospective pharmacovigilant study using the FAERS database and highlight sex-associated differen…

Chiesi Group, an international research-focused biopharmaceutical group, and KalVista Pharmaceuticals, Inc., announced that the companies have entered into a definitive agreement under which Chiesi will acquire KalVista (the “Transaction”). The Transaction was unanimously approved by both Chiesi’s a...

A team led by metabolism researcher Prof Timo D. Müller at Helmholtz Munich has developed a new approach for treating obesity and type 2 diabetes: a hybrid molecule uses the well-known GLP-1/GIP signalling pathway as a “door opener” and delivers an additional metabolic modulator specifically into th...

Glucagonlike peptide-1 (GLP-1) medications have taken over the national conversation around weight loss.

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, has awarded a $3.9 million grant to a multi-institutional team led by scientists at Sanford Burnham Prebys Medical Discovery Institute to develop a non-opioid pain therapeutic and advance it into a Phase 1 clinical trial.

A systematic review of randomized controlled trials evaluated the effectiveness and tolerability of pharmacologic prophylaxis for chronic migraines in adults.

Order signed by Samuel Alito blocks ruling that prevented providers from prescribing mifepristone through the mail The US supreme court has temporarily reinstated nationwide access to mifepristone, blocking a ruling that threatened to upend accessibility of an abortion pill involved in nearly two-thirds of pregnancy terminations across the country. On Monday, justice Samuel Alito signed an order …

Brucellosis, a zoonotic disease, triggers severe inflammation and reproductive complications in both humans and animals. The standard treatment protocol relies on prolonged antibiotic courses, often combining streptomycin and doxycycline, or gentamicin and doxycycline, for a duration of six to eight weeks. However, concerns have arisen regarding the efficacy, with a notable 15% failure rate and f…

It is appealing to think something as simple as honey could cure a cold or prevent hay fever, but is there evidence to back up honey’s health benefits? Columnist Alice Klein finds that it has legitimate medicinal uses, depending on the type of honey you’ve got

A new study suggests a surprisingly simple compound could help fight Alzheimer’s disease. Researchers found that arginine—an inexpensive amino acid already considered safe—can reduce the buildup of toxic amyloid proteins in the brain, a hallmark of the disease. In animal models, oral arginine not only lowered harmful protein deposits but also improved behavior and reduced brain inflammation.

Marijuana is far from a “silver bullet” for various illnesses, but it has some promising applications, scientists say

Weill Cornell Medicine investigators have "reverse engineered" ketamine's antidepressant effects to identify potential new strategies for treating depression.