pharmacology

BackgroundCadmium(Cd) exposure is associated with anxiety, but mechanism-informed multi-target interventions are limited.MethodsWe profiled plasma proteomes by LC-MS/MS in a propensity-score-matched Cd-exposed cohort (25 anxious vs 25 non-anxious). Anxiety-associated proteins were used as seeds for reverse screening in TCMIP v2.0, followed by network integration, molecular docking, 100ns molecula…

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01806-9 Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer

Radiochemistry and Radiopharmacy Solutions, more commonly known as RadCore, has launched an exciting new era of scientific possibility at Michigan State University, with several clinical trials underway fueled by the new central facility – the MSU Radiopharmacy. RadCore’s mission is to manufacture and transform raw radioisotopes into high-quality imaging and therapeutic agents for research studie…

Around a third of people with major depressive disorder don't respond to standard treatments –...

New NIH research reveals that semaglutide sparks different responses inside appetite-controlling brain cells, offering fresh insight into why GLP-1 weight-loss drugs don’t work the same for everyone. Scientists also found a possible way to extend the drugs’ effects, potentially helping patients push past weight-loss plateaus.

Recently, a research team led by Professors Dahong Zhang and Qi Zhang from the Urology Department and the Institute of Urology at Zhejiang Provincial People's Hospital and the Translational Medicine Center discovered that a bladder tumor-targeting polyarginine peptide, R11, can directly bind to actin, destabilize the G-actin tetramer, and trigger the cascade breakdown of the actin-plectin-vimenti…

A massive international study could upend 40 years of heart attack treatment. Researchers found that beta blockers—routinely prescribed after uncomplicated heart attacks—offered no real benefit for patients whose heart function remained normal, despite being given to millions worldwide. Even more surprising, women taking the drugs faced a higher risk of death, repeat heart attack, or hospitalizat…

Nearly 1 billion people across the world are affected by sleep apnea – and that's...

Scientific Reports, Published online: 25 May 2026; doi:10.1038/s41598-026-54828-y Protective effects of herbal toothpastes against dentin erosion: an in vitro study

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01829-2 Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication

Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73412-6 This study presents cryo-EM structures of the kinin receptors B1R and B2R bound to antagonists, revealing key residues that determine subtype selectivity and a shared mechanism that blocks receptor activation, thereby guiding future drug design.

BackgroundPrimary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by progressive cholestasis. Although ursodeoxycholic acid (UDCA) is the standard therapy, a substantial proportion of patients show inadequate response, highlighting the need for alternative or adjunct treatments. Fibrates have emerged as adjunct agents to UDCA, but evidence remains inconsistent across…

ObjectiveCarrier-based local hydromorphone delivery using absorbable materials represents an innovative strategy; however, comparative studies on various carriers remain scarce. This study aims to evaluate and compare the clinical efficacy of artificial dura mater versus gelatin sponge as carriers for hydromorphone in patients undergoing posterior lumbar interbody fusion (PLIF).MethodsThis single…

ObjectiveNon-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in children and adolescents, and there is no defined treatment for this condition. A network meta-analysis (NMA) was conducted to examine the comparative efficacy of specific mechanism pathways of drugs to achieve improvements in hepatic steatosis in pediatric NAFLD patients.MethodsRandomized cont…

IntroductionOxidative stress-mediated retinal pigment epithelial (RPE) cell injury is a key pathological feature of age-related macular degeneration (AMD). Ferroptosis—an iron-dependent form of regulated cell death driven by lipid peroxidation—has been increasingly identified as a critical executor of RPE degeneration and a key pathogenic mechanism in AMD. This study aimed to investigate the mech…

A new “Trojan horse” weight-loss drug sneaks extra metabolic power into cells and delivers striking results in mice. Researchers at Helmholtz Munich have developed a new drug strategy that could improve treatment for obesity and type 2 diabetes. Led by metabolism scientist Prof Timo D. Müller, the team created a hybrid molecule that uses the [...]

A small clinical trial found that a single low-dose infusion of ketamine reduced exhaustion in patients with various chronic illnesses. The findings suggest fast-acting medications could eventually offer relief for people struggling with debilitating and persistent tiredness.

A new study suggests the gut microbiome may retain long-term signatures of past medication use, with some drugs leaving detectable effects years after treatment ends. Your gut may carry a record of medications you stopped taking years ago. A large study from the University of Tartu Institute of Genomics suggests that prescription drugs can leave [...]