Comparative efficacy and safety of ursodeoxycholic acid, fibrates, and combination therapy in primary biliary cholangitis: an umbrella meta-analysis of meta-analyses
Qi Shen
BackgroundPrimary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by progressive cholestasis. Although ursodeoxycholic acid (UDCA) is the standard therapy, a substantial proportion of patients show inadequate response, highlighting the need for alternative or adjunct treatments. Fibrates have emerged as adjunct agents to UDCA, but evidence remains inconsistent across trials and meta-analyses.MethodsWe conducted a systematic review of meta-analyses evaluating fibrate