infectious-disease

BackgroundFabry disease, an X-linked lysosomal storage disorder, can present with mixed ventilatory dysfunction on pulmonary function testing. In patients with a smoking history, this finding may trigger a reflexive consideration of COPD and unnecessary bronchodilator use. We report a case where bronchodilators were briefly used following the diagnosis of Fabry disease, highlighting the clinical …

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04429-z An interim report of a first-in-human phase 1 trial found an adjuvanted, combination inactivated rabies-vectored, Lassa fever vaccine (LASSARAB + 3D-6-acyl PHAD-SE) to be safe and induced immunogenicity to both Lassa and rabies viruses in healthy participants.

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04482-8 Bundibugyo Ebola without vaccines or therapeutics: why public health fundamentals matter more than border closures

Researchers at the University of Maryland School of Medicine's Center for Vaccine Development and Global Health (CVD) reported encouraging results from an early clinical trial that tested a new dual vaccine against Lassa fever and rabies. The study, published today in the journal Nature Medicine, found that the vaccine was safe and induced immune responses against both viruses. There are currentl…

Nature Communications, Published online: 09 June 2026; doi:10.1038/s41467-026-74258-8 This study identifies coordinated TNFRSF upregulation as a potential proteomic signature of HIV associated stroke, reflecting both HIV-related inflammation and cerebrovascular injury, and providing candidate biomarkers for future investigation.

IntroductionSevere Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), a highly pathogenic coronavirus (CoV) belonging to Coronavirus B, has triggered outbreaks or pandemics. Currently, many variants of SARS-CoV-2 have evolved, which exhibit severe immune evasion and imprinting resistance to existing vaccines and cause infected individuals to develop Post-Acute Sequelae of SARS-CoV-2 (als…

BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of nosocomial infections and is associated with increased morbidity, mortality, and healthcare costs. Nasal carriage is a key reservoir for transmission and an important target for infection prevention. Data on MRSA prevalence, risk factors, and Panton–Valentine leucocidin (PVL) associated virulence in Central Africa,…

The bedaquiline (B), pretomanid (Pa), and linezolid (L) (BPaL) regimen is highly effective for drug-resistant tuberculosis (TB) but is limited by linezolid-associated toxicities, including myelosuppression and peripheral neuropathy. We evaluated omadacycline as a representative tetracycline-class protein synthesis inhibitor (PSI) to assess whether it can contribute functional activity within a BP…

Bacteria also produce molecules with an antiviral effect. Researchers at Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich (FZJ), together with colleagues from Marburg and Zurich, have investigated the antiviral molecule daunorubicin and deciphered its mode of action against vi...

While the infection is self-limiting in healthy adults, it can be fatal for children under five years, in whom the highest mortality is reported. The elderly and immunocompromised individuals are also highly vulnerable

A study of 1,474 Clue app users found that women vaccinated against COVID-19 during the follicular phase had higher odds of self-reported side effects than those vaccinated during the luteal phase.

The COVID-19 pandemic showed how quickly a virus can spread across the world and disrupt daily life. Millions of people became ill, healthcare systems were placed under enormous pressure, and economies suffered major setbacks. Although vaccines played a critical role in reducing severe illness and saving lives, the experience also exposed a weakness in the […] The post Could One Vaccine Protect A…

It is known that heatwaves promote the development of neurological events such as strokes. In addition, people with neurological diseases such as MS, Parkinson's, migraines or dementia are a particularly vulnerable group; rising temperatures lead to a noticeable worsening of their condition. The Ger...

A University of Minnesota Medical School research team was awarded a 5-year, $3.8 million grant from the National Institute of Allergy and Infectious Diseases to study early immune responses in the lung and how they influence tuberculosis infection outcomes.

IntroductionPrevious studies and society guidelines have proposed probiotics as a complementary therapy for acute infectious diarrhea, which may shorten the disease course, yet strain-specific effects and microbiome correlates remain incompletely defined. We aim to evaluate the effect of a combination of Lactobacillus acidophilus and Limosilactobacillus reuteri on the duration of diarrhea and gut…

Live Science spoke with Dr. Ali S. Khan, an epidemiologist and former assistant surgeon general of the U.S. Public Health Service, about the ongoing Ebola epidemic and the U.S.'s preparedness for future outbreaks.

For someone living with HIV, the number on a blood test can run their whole week. The drugs are supposed to push the virus below the threshold a machine can see, and most of the time they do. So when the lab comes back with a reading above 20 copies per millilitre, the worry sets in. Has the treatment failed? Is the virus loose again, ready to infect a partner? For a small group of patients, that…

Antiretroviral drugs for HIV infection have enabled most people living with the virus to live long and healthy lives.

For many years, doctors have focused on heart disease, stroke, kidney failure, and nerve damage as some of the most important complications of diabetes. However, a major new study suggests there is another serious health risk that deserves far more attention: infections. The research was published in the journal Diabetes and presented at the American […] The post Infections Are a Serious Threat f…