Frontiers in Microbiology | New and Recent Articles

The remediation of polycyclic aromatic hydrocarbon and lead co-contaminated soils in karst regions remains challenging because of strong soil buffering capacity, complex metal speciation, and the distinct transformation mechanisms of organic pollutants and heavy metals. Although urea and biochar are widely used as soil amendments, their interactive effects on plant-assisted remediation and the as…

Candida auris is an emerging multidrug-resistant fungal pathogen posing a major global health threat. In this study, we employed a targeted drug-repurposing strategy to identify novel indications for existing FDA-approved compounds against C. auris, leading to the identification of Tavaborole as a potent fungistatic agent. Tavaborole displayed robust activity across all five tested clades of C. a…

IntroductionPumpkin production in Guangxi, China, is increasingly affected by complex viral diseases, but the regional viral spectrum and mixed-infection structure in symptomatic pumpkin plants remain insufficiently characterized.MethodsWe analyzed 289 symptomatic pumpkin samples collected across Guangxi during 2022-2025 using small-RNA sequencing for virus discovery and targeted PCR/RT-PCR assay…

Disease symptom formation arises from complex interactions between a pathogen and its host. In sugarcane smut disease caused by Sporisorium scitamineum, the whip-shaped sorus—comprising intertwined fungal and plant tissues originating from the primary meristems of infected plants—is the most conspicuous symptom and a major cause of yield loss. Despite its agronomic significance, regulatory mechan…

Obligate methylotrophic bacteria are traditional biotechnological producers due to their ability to grow rapidly in extremely simple growth media. The aim of this study was to isolate a highly efficient methylotrophic producer from natural sources specifically for the “green” synthesis of metal nanoparticles. It was demonstrated that a pure bacterial culture of the genus Methylophilus is the most…

Ecological restoration can effectively boost soil fertility and microbial activity in degraded ecosystems. Yet, its impact on the relationship between soil-specific enzyme activity (SSEA) and microbial necromass carbon in barren sandy soils is still poorly understood. Therefore, we aimed to analyze the effects of ecological restoration on the SSEA per unit of soil organic carbon (SOCE) and SSEA p…

Antimicrobial resistance (AMR) represents a critical and escalating threat to global health, driven not only by microbial evolution but also by fundamental limitations in the pharmacokinetic and spatial delivery of antimicrobial agents in vivo. Conventional antibiotics exhibit non-specific systemic distribution, frequently fail to achieve sustained therapeutic concentrations at infection sites, a…

Rapid and accurate detection of pathogenic microorganisms is the key to clinical diagnosis and treatment as well as public health prevention and control. As a representative of the third-generation sequencing technologies, nanopore sequencing technology has brought revolutionary potential to the field of pathogen detection by virtue of its unique advantages such as long read length, real-time seq…

IntroductionSoil microbial communities play a central role in material cycling and energy transformation within grassland ecosystems. Alterations in their community structure, diversity, and function directly influence soil ecological functions and ecosystem stability. Global warming exerts persistent environmental pressure on soil microbial communities by modifying soil water and thermal conditi…

IntroductionDental caries, a highly prevalent oral disease, significantly compromises oral health. Dental biofilms represent a key etiological factor in caries pathogenesis and pose challenges for eradication due to their protective extracellular matrix.MethodsHerein, we rationally designed a ferro-polydopamine nanozyme (FPN) featuring a flower-like morphology and remarkable peroxidase-like (POD-…

IntroductionThe growth-inhibiting effect of the peptide Uy234, present in the venom of the scorpion Urodacus yaschenkoi, has been investigated in two bacterial pathogens: Staphylococcus aureus ATCC 25923 and Acinetobacter baumannii AE12, the latter being a multidrug-resistant clinical isolate. With the aim of determining the possible role of specific residues in the bioactivity of this peptide, w…

BackgroundCentral line-associated bloodstream infections (CLABSIs) are among the most serious healthcare-associated infections in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare burden. However, evidence regarding the epidemiology and outcomes of CLABSI in Saudi Arabian ICUs remains limited. This systematic review and meta-analysis aimed to evaluate the…

BackgroundStudies have shown that dysregulation of the gut microbiota (GM) plays a crucial role in the development of endometriosis (EMs). Study aimed to investigate the potential of protective GM metabolites in treating EM through network pharmacology and Mendelian randomization (MR), opening new avenues for targeted therapeutic strategies.MethodsAll data were sourced from publicly available dat…

Antibiotic resistance poses one of the most pressing threats to global public health, underscoring the urgent need for novel antimicrobial agents. Mushroom-derived polysaccharides have attracted considerable attention due to their structural diversity, low toxicity and various pharmacological activities. This review provides a comprehensive overview of the antiviral, antibacterial, and antifungal…

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major non-typhoidal Salmonella serovar associated with a substantial global burden of foodborne and invasive infections. Its transmission across human, animal, food, and environmental interfaces highlights its significance its relevance within a One Health framework. The pathogenicity of S. Typhimurium is mediated by multiple virulence…

IntroductionA novel electro-supported dynamic membrane bioreactor (EDMBR) was by integrating electrode function into a dynamic membrane module made of a stainless steel mesh support with a pore size of 444 mm. This work aimed to investigate the effects of voltage application on stabilization time, hydrogen production performance, metabolic pathway shift, and microbial community change during cont…