neurology

A new study led by researchers from VIB and KU Leuven shows that Parkinson's disease can be divided into distinct subtypes, helping explain why a single treatment does not work for all patients.

Alzheimer’s Research UK says patients at risk of being left behind as lack of formal or accurate diagnoses closes door to trials People with Alzheimer’s disease are missing out on experimental treatments because they are not diagnosed early or accurately enough to be enrolled in clinical trials, a UK charity has said. Trials of Alzheimer’s drugs reached a record high this year, according to data …

Parkinson’s disease is a condition that slowly affects the brain and body over time. It is most often diagnosed in people between the ages of 55 and 65, although it can sometimes appear earlier. The disease affects movement, causing symptoms such as shaking, slow movement, stiffness, and problems with balance. It can also affect sleep, […] The post Exercise may be the best medicine for Parkinson’…

BackgroundFrontotemporal dementia is an umbrella term that encompasses several clinical syndromes with impaired behavioral, language, and motor functions. These syndromes show considerable overlap in clinical features and imaging patterns. Therefore, there is a need to investigate the syndromic heterogeneity in FTD using unbiased data-driven approaches.MethodsWe used data-driven clustering analys…

IntroductionThe aim of the study is to investigate the association between fatigue, cognitive impairment, and overall QoL in individuals with Multiple Sclerosis (MS).MethodsFifty-one patients with MS with a confirmed diagnosis of relapsing–remitting multiple sclerosis (RRMS), according to established diagnostic criteria were enrolled. Data were collected at a single time point to examine associat…

A new study led by researchers from VIB and KU Leuven shows that Parkinson's disease can be divided into distinct subtypes, helping explain why a single treatment does not work for all patients. Using an machine-learning-driven analysis, the team identified two main groups and five subgroups of the disease, marking an important step toward more personalized therapies. The findings were recently p…

A systematic review of randomized controlled trials evaluated the effectiveness and tolerability of pharmacologic prophylaxis for chronic migraines in adults.

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A new study suggests a surprisingly simple compound could help fight Alzheimer’s disease. Researchers found that arginine—an inexpensive amino acid already considered safe—can reduce the buildup of toxic amyloid proteins in the brain, a hallmark of the disease. In animal models, oral arginine not only lowered harmful protein deposits but also improved behavior and reduced brain inflammation.

ObjectiveThis study aims to investigate the correlation between trace element concentrations, 25-hydroxyvitamin D [25(OH)D] levels, and the severity of tic disorders (TD) in children from the Hubei region. Additionally, it seeks to explore the interrelationships among these monitored indicators to provide a reference for the clinical diagnosis and treatment of pediatric TD.MethodsA retrospective …

Post-stroke cognitive impairment (PSCI) has garnered widespread attention due to its high incidence and its association with increased risk of stroke recurrence and mortality. Growing evidence indicates that early prediction of PSCI and the implementation of effective interventions can help delay disease progression and improve long-term patient outcomes. With advances in imaging technology, the …

BackgroundMutations in the PLA2G6 gene cause a spectrum of neurodegenerative disorders, with autosomal recessive early-onset Parkinson’s disease (AREP) and dystonia-parkinsonism (DP) representing the two primary subtypes of adult-onset PLA2G6-associated neurodegeneration (PLAN).Case presentationWe report a Chinese female patient with parkinsonism caused by compound heterozygous mutations in the P…

BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant-based foods and known for its potent antioxidant properties. Previous studies have shown that Dp3G suppresses oxidative stress and inflammation in atherosclerosis, protects again…

Alzheimer’s disease is widely known as a condition that affects memory and thinking. It is the most common cause of dementia and has a growing impact on people around the world. For many years, scientists have focused on changes inside the brain to explain how the disease develops. But new research is now suggesting that […] The post Your diet and gut may shape Alzheimer’s risk years before sympt…

IntroductionThe long-term efficacy of electroacupuncture (EA) in treating cognitive symptoms of Alzheimer’s disease (AD) remains unclear, and its time-dependent relationship requires further investigation.MethodsSixty-six patients were allocated to the EA or sham EA group, with stimulation for 20 minutes, for a 24-week treatment period, and were followed-up at 4 weeks. The primary outcome was the…

Drugs designed to clear amyloid beta from the brain—once seen as a promising path to slowing Alzheimer’s—may not actually help patients in any meaningful way, according to a major review of over 20,000 participants. Even more concerning, they may increase the risk of brain swelling and bleeding, sometimes without obvious symptoms.

The 18th BioVaria brought a record 360 participants from across the international life-science community to Munich. As Europe's leading platform for commercially promising academic innovations, BioVaria connects researchers, entrepreneurs, investors, and industry partners - accelerating the path fro...

The 18th BioVaria brought a record 360 participants from across the international life-science community to Munich. As Europe's leading platform for commercially promising academic innovations, BioVaria connects researchers, entrepreneurs, investors, and industry partners - accelerating the path fro...

Parkinson’s disease is a condition that slowly affects the brain and makes movement harder over time. People with Parkinson’s may notice shaking, stiffness, and trouble with balance. These symptoms happen because certain brain cells stop working properly. These cells are responsible for making dopamine, a chemical that helps control smooth movement. Most current treatments help […] The post Exper…

Alzheimer’s disease is one of the most serious health challenges in the world today. It affects more than 55 million people, and that number is expected to grow quickly in the coming years. For a long time, scientists believed that Alzheimer’s begins in the brain, caused by the slow buildup of harmful proteins that damage […] The post Could Alzheimer’s start in the gut? appeared first on Knowridg…