developmental-biology

A common recessive NDD caused by RNU2-2 mutations disrupts brain development and opens paths for diagnosis and therapy. Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified a newly recognized recessive neurodevelopmental disorder (NDD) that may be the most common of its kind discovered so far. The condition is [...]

IntroductionDevelopmental Language Disorder (DLD) is a common neurodevelopmental condition that affects both the structural and pragmatic aspects of language. Conversational abilities—including topic initiation, maintenance, repair, turn-taking, and the integration of non-verbal behaviors—are essential for social communication and peer relationships. While a substantial body of research has descr…

Scientific Data, Published online: 05 May 2026; doi:10.1038/s41597-026-07396-9 Integrated respiratory metabolism and hemolymph proteome of caste specific features during honeybee ( Apis mellifera L.) development

Amblyopia is a common childhood visual disorder caused by abnormal visual experience that drives visual cortical plasticity during the sensitive period. The timing and forms of treatment with patching therapy and other therapeutic interventions have been extensively studied; however, sex has not been a primary focus in studies examining amblyopia. This mini-review synthesizes evidence for sex dif…

BackgroundThis study investigated whether manual therapy applied to tendon organs ameliorated neuromuscular dysfunction in rats with spasticity induced by upper motor neuron injury associated with spastic cerebral palsy, and analyzed the potential involvement of the C-fiber-mediated CaMKII signaling pathway.MethodsMale rats were used to establish palsy models and divided into groups: Control, Mod…

A University of California, Riverside study reports that cells in the earliest stages of human development could be susceptible to infection by SARS-CoV-2, which causes COVID-19, offering new insight into how the virus interacts with developing human tissues and why that may matter for pregnancy research.

Nature Cell Biology, Published online: 04 May 2026; doi:10.1038/s41556-026-01949-1 Li, Huo, Zhang, Liu and colleagues report that the transcripts of genes involved in haematopoietic stem cell function share a protective mechanism against RNA decay through a non-canonical function of NAT10, independent of its N4-acetylcytidine catalytic activity.

By the time researchers had catalogued 102 genes linked to autism in a single landmark paper five years ago, a quietly uncomfortable question had settled over the field. How could so many genes, doing such different jobs, produce something that looks so much like the same disorder? Some govern how chromosomes are packaged. Others regulate the junctions between neurons. Still others keep brain cel…

BackgroundDevelopmental Coordination Disorder (DCD) affects approximately 5–6% of school-aged children and is characterized by significant motor skill impairments that may persist into adulthood without intervention. Aquatic-based swimming programs have been proposed as a feasible approach to support motor development in children with neurodevelopmental motor difficulties. However, evidence speci…

Embryo Development in Space: Can Humans Reproduce Beyond Earth? Human embryos can begin early development in microgravity, but they do not develop normally under current conditions. Human reproduction beyond Earth faces significant challenges due to microgravity and high radiation, which can impair sperm motility, damage DNA, and disrupt early embryo development. Studies on animals and human cell…

Primary human intestinal epithelial cells (IECs) require microenvironments that reproduce various in vivo cues to maintain survival, differentiation, and function in vitro. In this study, we investigated how intestinal stem cell (ISC)-derived monolayers respond to biomimetic substrates and shear stress using 3D-printed hydrogels based on bioactive decellularized and methacrylated small intestinal…

Nature Communications, Published online: 01 May 2026; doi:10.1038/s41467-026-71821-1 Addendum: Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Nature, Published online: 01 May 2026; doi:10.1038/d41586-026-01428-5 Mini models of the uterus lining give insight into mystery of how it is shed without scarring.

Years before he conducted the research that would earn him a Nobel Prize in Physiology and Medicine, Shinya Yamanaka, MD, PhD, was a postdoctoral scientist at Gladstone Institutes, studying genes.

Childhood abuse forces the biological clock to tick faster and curbs children's willingness to make eye contact, independent consequences that both track with higher rates of emotional and behavioral problems.

BackgroundAutism Spectrum Disorder (ASD) is primarily characterized by differences in communication and social interaction, but motor impairments are also commonly observed, often emerging in early childhood. Understanding these motor characteristics may contribute to earlier identification and intervention. This study aimed to compare walking kinematics between autistic and non-autistic preschoo…