Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement
Vibhu Sahni
Nature Communications, Published online: 22 May 2026; doi:10.1038/s41467-026-73476-4 Here authors show cortico-brainstem neurons are molecularly specified in early development to restrict axon growth to the brainstem without extending to spinal cord. This developmentally defined circuit persists into adulthood and supports skilled forelimb movement.