The V-ATPase/ATG16L1 axis drives membrane remodeling during epithelial morphogenesis
Fernando Martín-Belmonte
Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73471-9 Here they show that, during lumenogenesis, noncanonical autophagy drives formation of a single central cavity by controlling membrane recycling, while canonical autophagy supports its growth, and provide insights into tissue development from neural tube organoids.