C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice
Juan Zhang
Nature Communications, Published online: 21 May 2026; doi:10.1038/s41467-026-73368-7 Obesity shows sexual dimorphism. Here, the authors identify the germ cell -specific gene C2orf74 as a driver of diet induced obesity via suppression of androgen signalling and subsequently white adipocyte browning in male but not in female mice.