genetics

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74021-z The study shows that disruption of calcium homeostasis triggers the aberrant accumulation of S100A6 in the cytoplasm, thereby promoting Hutchinson-Gilford Progeria Syndrome (HGPS) and natural aging. Mianserin was found to effectively retard the aging process and significantly extend the lifespan of both progeroi…

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74090-0 DNA damage repair enzymes protect genomes by recognizing and removing harmful lesions before they become mutations. Here, the authors map how these enzymes bind thousands of damaged DNA sequences, revealing sequence and structural recognition rules linked to genome-wide mutation patterns.

Scientific Data, Published online: 06 June 2026; doi:10.1038/s41597-026-07585-6 A Dataset of Benchmark Boolean Models for Gene Regulatory Networks

Scientific Data, Published online: 06 June 2026; doi:10.1038/s41597-026-07589-2 High quality genome assemblies of African cattle breeds using PacBio HiFi sequencing

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-73793-8 Flowering plants can undergo whole-genome duplications, but how they return to diploid-like states is poorly understood. Here authors show diploidization in the Biscutella genus is shaped by clade divergence and constrained by shared genomic features.

Scientific Reports, Published online: 06 June 2026; doi:10.1038/s41598-026-55649-9 Genetic diversity of Cimex hemipterus and first report of Wolbachia supergroup T in Tehran, Iran: insights from COI and 16 S rRNA analysis

The study, published in Volume 153, Issue 9 of the journal Development on May 14, 2026, by The Company of Biologists, is the first to precisely map endogenous UTY occupancy across the human genome and demonstrate that UTY remains functionally involved in transcriptional regulation during early human development.

Nature, Published online: 05 June 2026; doi:10.1038/d41586-026-01827-8 The ‘base editing’ technique that researchers used is far from ready for the clinic, but critics worry it will spur a rush to commercialization.

Damage to DNA in cancer cells can lead to pieces breaking off chromosomes and floating away, like icebergs cracking off from a glacier. Scientists at Sanford Burnham Prebys Medical Discovery Institute and their colleagues published findings May 28, 2026, in Genome Medicine demonstrating significant similarities between samples of tumors featuring these stranded DNA fragments and research models d…

Damage to DNA in cancer cells can lead to pieces breaking off chromosomes and floating away, like icebergs cracking off from a glacier.

BackgroundThe incidence of bipolar disorder (BD) is an ongoing global public health concern, driving a heightened focus on elucidating its underlying pathophysiology. Mounting evidence indicates that epigenetic mechanisms play a pivotal role in the onset and progression of BD, presenting promising avenues for identifying novel biomarkers and therapeutic targets. However, a comprehensive bibliomet…

BackgroundComplex febrile seizures (CFS) confer an elevated risk of epilepsy progression; however, the underlying genetic architecture remains insufficiently characterized in Chinese pediatric populations. This study aimed to delineate the mutational landscape and genotype–phenotype associations in a clinically stratified high-risk febrile seizure cohort.MethodsThis retrospective, single-center s…

Scientific Data, Published online: 05 June 2026; doi:10.1038/s41597-026-07526-3 DNA methylation profiles of quail blood cells by whole-genome bisulfite and Oxford Nanopore sequencing

Researchers found that, although antibody evolution is highly chaotic at the level of individual cells, germinal centers reliably produce stronger antibodies through repeated rounds of mutation and selection that are only slightly biased toward success.

Mice that contain cells with an added rat chromosome have been created by scientists. The next step is to try this with frozen elephant tissue – and if that works, the team will try it with frozen mammoths

Announcing a new article publication in BIO Integration. Latent tuberculosis infection (LTBI) is difficult to diagnose due to the lack of a definitive gold standard.

IntroductionThe Yunnan pony is an officially protected pony breed in China. However, its gut microbiome characteristics remain largely unexplored. This study aimed to compare the gut microbiome and antibiotic resistance genes (ARGs) profiles between Yunnan ponies and Dutch warmblood horses.MethodologyA total of 14 fresh fecal samples were collected from Yunnan ponies and Dutch warmblood horses. M…

At National Institute of Plant Genome Research. Candidates are invited to appear before the selection committee for filling up the purely temporary …