Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy
Hannele M. Laivuori
Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73122-z Intrahepatic cholestasis of pregnancy is a common liver disorder with poorly defined genetic causes. Here, the authors identify 26 risk loci through a large GWAS meta‑analysis, implicating bile acid and lipid metabolism pathways and revealing shared genetic architecture with pancreatitis.