Light- and chemical-induced ciliary signaling governs dorsal/ventral regionalization of human telencephalic organoids
Yoichi Kato
Nature Communications, Published online: 22 May 2026; doi:10.1038/s41467-026-73505-2 Brain regionalization is a critical process for human brain development. Here, Shimada et al. show that the primary cilium, a hair-like projection on the cell surface, helps determine regional identity in human brain organoids. Altering signaling in the cilium is sufficient to change neural progenitor cell fate.