biochemistry

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-77053-7 Biomass derived α-, β-hydroxy acids can provide greener routes to valuable amino acids, but selective conversion remains difficult. This study shows isolated ruthenium sites can drive a new pathway from hydroxy acids to amino acids.

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-76869-7 Reductive amination catalysed by imine reductases and reductive aminases is a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, the authors combine large-scale, iterative activity screening, sequence anal…

Cancer drugs are often designed to block specific molecular targets, but what happens after they enter a cell is not always well understood. A new study published in Biophotonics Discovery demonstrates how advanced imaging technology can help answer that question. Using super-resolution microscopy, researchers tracked the cancer drug sunitinib inside living cells and observed how […]

For a new drug to work in the human body, it must make its way to the exact cell type where it's needed and then, in many cases, get inside the cells.

Your birthday tells you how many years you have been alive. But it cannot tell...

Swinburne researchers have discovered how broccoli could help treat an extremely rare and incurable disease that affects only about 200 Australians. A naturally occurring compound in broccoli is being investigated as a possible treatment for Friedreich ataxia, a rare nervous system disease. Research from Swinburne suggests the compound can act on biological processes involved in [...]

Aconitum tanguticum (Maxim.) Stapf., commonly known as “Bangga” when used in combination with Aconitum naviculare (Brühl.) Stapf., is a traditional Tibetan medicine widely used in medicinal preparations. It is documented in the Si-Bu-Yi-Dian and Jing-Zhu-Ben-Cao and is mainly used to treat infectious and inflammatory conditions such as fever, liver and biliary disorders, lung diseases, gastroente…

In a new study, scientists from Johns Hopkins Medicine report that an experimental mRNA-based platform has the potential to help deliver next-generation mRNA therapeutics, including vaccines fighting against infectious disease, cancer and autoimmune conditions, faster and more efficiently than the industry standard.

Xiao Wang, the Thomas D. and Virginia Cabot Associate Professor of Chemistry and Core Member of the Broad Institute of MIT and Harvard, has been selected as the recipient of the 2027 Eli Lilly Award in Biological Chemistry. Administered by the Division of Biological Chemistry (BIOL) of the American Chemical Society (ACS) and sponsored by […]

A comprehensive review published in Engineering systematically outlines the regulatory capacity of silent information regulator 3 (SIRT3), a mitochondrial deacetylase termed the "head goose molecule", and its negentropic mechanism for intervening global metabolic disorders including type 2 diabetes, obesity, and steatotic liver disease.

Rather than generating new wet-lab data for every compound, DeepCyte trains a foundation model that is capable of predicting toxicity mechanisms for compounds that it has never measured. The post DeepCyte Launches Single-Cell Metabolomic Reference Atlas of Drug Toxicity Mechanisms appeared first on GEN - Genetic Engineering and Biotechnology News .

Nature Chemistry, Published online: 21 August 2026; doi:10.1038/s41557-026-02230-6 Bioorthogonal chemistry has greatly advanced our ability to explore and manipulate biological systems. Now, a genetically targeted photocatalytic strategy enables spatially controlled, non-natural organic transformations in specific cell types and subcellular compartments, combining abiotic reactivity with biologic…