organic-chemistry

Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72920-9 Ru-catalyzed asymmetric ring-closing metathesis (ARCM) reactions are less reported and restricted to the synthesis of tertiary stereocenters. Herein, the authors report ARCM to produce chiral heterocyclic compounds with quaternary stereocenters, by synthesizing stereogenic-at-Ru catalysts via controllable C–H act…

Scientific Reports, Published online: 05 May 2026; doi:10.1038/s41598-026-47154-w Novel green synthesis of polyfunctionally substituted phthalazines promoted by visible light, DFT studies and molecular docking with antimicrobial and antibiofilm potency

Curiosity just found molecules on Mars tied to the chemistry of life, hinting at a more habitable past. NASA’s Curiosity rover has discovered a wide variety of organic molecules on Mars, including compounds often viewed as essential ingredients for the origin of life on Earth. These results come from a chemical experiment carried out on [...]

Nature Communications, Published online: 02 May 2026; doi:10.1038/s41467-026-72546-x Alkene 1,1- difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular frameworks. Here, the authors report an electrochemical strategy for 1,1-difunctionalization of halogenated aromatics with unactivated alkenes, …

Nature Communications, Published online: 02 May 2026; doi:10.1038/s41467-026-72684-2 The development of chemoenzymatic dynamic kinetic resolution has long been constrained by principal limitations, which need precise synchronization of racemization and resolution steps for rate matching. Here, the authors introduce a membrane-modulated strategy that circumvents the mandatory requirement for stric…

Nature Communications, Published online: 01 May 2026; doi:10.1038/s41467-026-72121-4 Bimolecular nucleophilic substitution is a fundamental reaction in organic chemistry. Here, the authors uncover a “flip-over” retention mechanism for the SN2 pathway of Cl− + (CH3)3CI from molecular cross beam experiments and dynamics simulations.

Nature Communications, Published online: 01 May 2026; doi:10.1038/s41467-026-72120-5 A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl‒ and (CH3)3CI can proceed via a flip-over mechanism — a new type of SN2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.

NASA’s Curiosity Mars rover found organic molecules that have never been seen before on Mars. A rock that the rover drilled and analyzed in 2020 includes the most diverse collection of organic molecules ever found on Mars, NASA announced last week. Of the 21 carbon-containing molecules identified in the sample, seven of them had never… The post Martian chemistry: how the Curiosity rover detected …

Nature Communications, Published online: 30 April 2026; doi:10.1038/s41467-026-72564-9 Traditional bisphenol A diglycidyl ether (BADGE) synthesis from bisphenol A and epichlorohydrin using NaOH suffers from side reactions, low purity product and high viscosity. Here, the authors report an organocatalytic NaOH-free route, yielding higher purity BADGE and improved epoxy resins.

A study of the organic compounds in the lunar crust and in terrestrial model systems. Preti, George. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1971; Vita.; Includes bibliographical references.

An examination of esterification of sebacic acid and iso-octyl alcohol Bhadani, Surendra Kumar. Thesis: B.S., Massachusetts Institute of Technology, Department of Chemical Engineering, 1955; Bibliography: leaf 43.

Career paths in organic chemistry are not always linear, and returning after a career break (≥2 years) can be challenging. The DOC is seeking to better understand the experiences of those who have struggled to re-enter the field, as well as those who have successfully navigated a return. If this applies to you―or someone you … Read More The post Returning to the Organic Chemistry Working World af…

Nature Communications, Published online: 30 April 2026; doi:10.1038/s41467-026-72466-w Penicillin derivatives remain among the most widely prescribed antibiotics. In this study, the authors report an alternative pathway to penicillins that uses standalone ligase and epimerase enzymes to generate peptide precursors, which can be transformed into penicillin derivatives using an engineered isopenici…

Nature Catalysis, Published online: 29 April 2026; doi:10.1038/s41929-026-01532-9 Stereoselective radical C–C couplings remain a major challenge. Now photometallobiocatalytic cross-coupling of organotrifluoroborates and α-diazoesters is achieved with high enantio- and diastereoselectivity via an outer-sphere radical mechanism mediated by engineered cytochrome c and eosin B.

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10463-1 A Pd-catalysed method enables regio- and diastereoselective C–H alkylation of diverse alkenes using carboxylic acids, expanding synthetic access to complex substituted alkenes.

MustGrow Biologics has received Georgia Department of Agriculture registration for TerraSante™, its mustard plant-based organic biofertilizer. The post MustGrow Biologics Secures Georgia Registration for TerraSante™, Expanding Organic Biofertilizer Reach in High-Value Crop Markets appeared first on iGrow News .

New research from Professor Anna Slater and colleagues at the University of Liverpool demonstrates how continuous flow chemistry, combined with inline UV-Vis spectroscopy, can transform both the understanding and execution of porphyrin synthesis leading to improved yields in both quality and quantity.