organic-chemistry

Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02167-w The endo-facial stereoselective transformation of norbornadiene (NBD) remains underdeveloped. Now a nickel(0)-catalysed endo-selective [2+2] cycloaddition of NBDs with unactivated internal alkynes is reported, enabled by ligand-mediated facial differentiation of NBDs and nickel-controlled configuration of a key inter…

Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02164-z A deconstructive alkaloid remodelling strategy comprising a concise set of robust transformations is introduced. Twenty-six altered frameworks are synthesized, requiring an average of ~1.8 steps per analogue. In cellulo evaluation across ten cancer cell lines indicates that an expanded amine bridge and a deconstructe…

Scientific Reports, Published online: 05 June 2026; doi:10.1038/s41598-026-54643-5 One-pot click synthesis of hybrid triazole–pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays

The ACS Division of Organic Chemistry and ACS Publications are proud to announce the winners of the 2026 Organic Letters, Journal of Organic Chemistry, Organometallics, and Organic Process Research & Development lectureship awards. See the ACS Axial article for more information. The Journal of Organic Chemistry Award: Jun Xiao and colleagues at Pfizer, USA, are … Read More The post ACS Catalysis,…

We demonstrate the utility of a simple Oxygen-to-Sulfur exchange for covalent warhead design and related applications. Our findings establish this approach as a powerful strategy for fine-tuning covalent reactivity and expanding the chemical toolbox of covalent drug discovery and chemical biology.

There is a relationship between the chemical structure of dyes and their fastness properties. The assessment of colour fastness is a critical quality control process in the textile industry in order to ascertain that dyed fabrics maintain their aesthetic integrity under various conditions.

Dyes are of great industrial applications . Benzimidazole-based azo dyes are particularly suitable for various applications including high-performance textile colourants and photo-switches and are crucial in textile industry because of their exceptional colour brilliance and fastness properties.

Nature Catalysis, Published online: 03 June 2026; doi:10.1038/s41929-026-01552-5 Selective C–C bond activation adjacent to two heteroatoms is challenging due to competing C–X cleavage. This work develops a Ni–Al catalytic system that enables precise activation of the inert C2–C3 bond in β-lactams, facilitating efficient annulations with π-systems with high regiocontrol.

Though it's a toxic chemical, hydrogen cyanide (HCN) is also important for the development of life. It's a precursor to things like amino acids and nucleic acids and plays a central role in theories of the origin of life on Earth. Recently, difficult questions have been asked about how it could have formed on the early Earth. But the authors of new research in PNAS seemed to have figured it out.

Nature Catalysis, Published online: 02 June 2026; doi:10.1038/s41929-026-01548-1 The C–H activation of secondary and tertiary amines under directed Pd(II) catalysis remains challenging. Now the authors report a Pd-catalysed, site- and diastereoselective C3-C(sp3)–H arylation of saturated azacycles, enabled by conversion of the endocyclic nitrogen as N-oxide directing group and a bifunctional liga…

Nature Chemistry, Published online: 01 June 2026; doi:10.1038/s41557-026-02173-y A strategy is developed that merges triplet nitrene-mediated ring expansion with titanium-catalysed cyanylation for the diastereoselective synthesis of vicinal tetrasubstituted cyclobutane amino nitriles. This strategy unlocks highly functionalized and congested three-dimensional cyclobutanes that could provide scaff…

Nature Chemistry, Published online: 01 June 2026; doi:10.1038/s41557-026-02156-z The availability of sterically hindered vicinal tetrasubstituted amino acids has long been a formidable challenge in medicinal chemistry due to their rigid structures. Now it has been shown that leveraging triplet nitrene reactivity and combining it with titanium catalysis enables access to these valuable building bl…

Nature Communications, Published online: 01 June 2026; doi:10.1038/s41467-026-73603-1 The properties of vinyl polymers are highly influenced by their tacticity, but controlling this is a challenge. Here, the authors report a protected vinylboron monomer for tacticity controlled polymerisations, yielding highly syndiotactic poly(vinyl alcohol)s.

Based in the Department of Chemistry at the University of Bath, the Morrill research group is focused on developing new reactions in organic chemistry and sustainable catalytic methodologies for electrosynthesis The post Parallel Electrochemistry for he development of new electrosynthetic methods at Bath University appeared first on Asynt .

Nature Communications, Published online: 01 June 2026; doi:10.1038/s41467-026-73762-1 Organic electrochemical transistors (OECT) rely on the coupling between ionic and electronic species. Here, Zhang et al. show that delaying cation expulsion enables an anion-cation dual-doping mechanism in OECTs, thus improving current sensitivity and fidelity for physiological signal acquisition.

People have been consuming tobacco for millennia, though it wasn't until the late 1820s that...

Nature Communications, Published online: 30 May 2026; doi:10.1038/s41467-026-73842-2 Sulfide is an important bacterial signal, but how bacteria detect it remains unclear. Here the authors show that NreB uses an unusual iron-sulfur cluster with a labile sulfur ligand to sense sulfide and regulate kinase activity.

Nature Chemistry, Published online: 29 May 2026; doi:10.1038/s41557-026-02166-x Ketones are versatile, but converting them to ketyl radicals typically requires harsh conditions. Now a mild method using a bifunctional silyl reagent has been shown to generate ketyl-type radicals through a radical translocation strategy, enabling redox-neutral Pd-catalysed ketone–olefin couplings to give diverse alk…