organic-chemistry

Scientific Reports, Published online: 15 June 2026; doi:10.1038/s41598-026-47290-3 Chemical composition of essential oil from Lavandula dentata L. to control citrus aphids selectively

Nature Chemistry, Published online: 12 June 2026; doi:10.1038/s41557-026-02148-z N-aryl pyrazole is a prevalent motif among pharmaceuticals across various therapeutic areas but can be challenging to synthesize due to the high similarity of the two nitrogen atoms. Now it has been shown that the use of copper catalysis and arynes provides a switchable protocol to access both regioisomers.

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74370-9 Direct asymmetric α-C conjugate addition of aminomethylphosphonate to α,β-unsaturated ketones is an intriguing strategy to make bioactive chiral phosphonic 1-pyrrolines. Here, the authors present a direct enantioselective α-C conjugate addition of NH2-unprotected aminomethylphosphonate to α,β-unsaturated ketones…

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74186-7 The authors report a visible-light-mediated, chiral Brønsted acid-catalyzed C2-umpolung of 3-azoindoles, enabling their catalytic asymmetric formal nucleophilic C2-substitution with 2-substituted indoles. This strategy provides efficient access to axially chiral 2,3’-bisindoles in good yields with excellent enan…

“I was a non-STEM major when I moved to the US 10 years ago, and I never thought I could be good at science. But my parents were like, ‘You're in the new world, why don't you try new stuff?’ I don't know why, but I decided to study chemistry—and it was amazing. … Somehow I got into UCSD as a transfer student, and I joked to my friend that I would go to Caltech for grad school. But then I actually…

Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02198-3 Author Correction: [2+2] Photocycloaddition reactions of sulfinylamines with alkenes to access β-sultam derivatives

Organic foods are not healthier...or pesticide free. Organic farming is a marketing ploy that exploits the appeal to nature fallacy As a biomedical scientist, it has never failed to annoy me that the term ‘organic’ has been co-opted to spread misinformation. Before we get into the topic as it relates to foods (and other consumer products), I just want to emphasize that the term organic in chemist…

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10580-x A chemical and biological redox process that resembles processes in petrochemical refining is used to convert lignin from poplar into a single, valuable bioproduct, adipic acid, in high yields.

Nature, Published online: 10 June 2026; doi:10.1038/d41586-026-01586-6 An ingredient of nylon has been made in high yields from lignin — revealing a fresh strategy for turning this complex plant biopolymer into industrial chemicals.

Nature Communications, Published online: 10 June 2026; doi:10.1038/s41467-026-74372-7 Benzocyclobutenes (BCBs) represent a highly strained, privileged structural motif with significant applications in drug discovery, medicinal chemistry, organic synthesis, polymers and materials science, yet efficient synthetic methods remain limited. Here, the authors report an oxidant-free Au(I)/Au(III)-catalyz…

Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02177-8 Selective radical capture remains a central challenge in transition metal-catalysed transformations involving multiple radical intermediates. Now a ligand-modulated metal–radical polarity-match mechanism exploiting electronic bias for selective radical capture has been identified. This principle enables general photo…

Nature Communications, Published online: 10 June 2026; doi:10.1038/s41467-026-74244-0 Skeletal editing enables direct structural reorganization of molecular frameworks, providing a powerful strategy for rapid exploration of chemical space in lead optimization. Herein the authors report a mild, photoinduced skeletal editing strategy that converts furans into pharmacologically valuable pyridazines …

Nature Catalysis, Published online: 09 June 2026; doi:10.1038/s41929-026-01539-2 Direct hydrogen atom transfer (d-HAT) for C(sp3)–H functionalization classically relies on O-centred photocatalysts. Now, neutral N-centred acridine photocatalysts have been added to the toolbox, enabling mild, scalable d-HAT that is compatible with a broad substrate scope and transition metal catalysis.

Nature Catalysis, Published online: 09 June 2026; doi:10.1038/s41929-026-01549-0 Functionalization of saturated azacycles through Pd-catalysed C3-C(sp3)–H activation leveraging the endocyclic nitrogen as a directing group has been hindered by the intrinsic geometric strain of the palladacycle intermediate. Now, an amine N-oxide strategy overcomes this issue by forming a favourable five-membered p…

Nature Communications, Published online: 09 June 2026; doi:10.1038/s41467-026-74395-0 Existing synthetic approaches to 3-azabicyclo[3.2.0]heptane and 3-azabicyclo[3.1.1]heptane cores are typically restricted to single scaffolds, limiting scaffold diversity. Here, the authors report a ligandcontrolled, palladium-catalyzed tandem dicarbonylation of readily available cyclobutenols and amines, enabli…

The ACS Division of Organic Chemistry (DOC) wishes to congratulate the winners of the 2026 Early Career and Mid-Career Investigator Awards. These scientists will present their work at the ACS National Meeting held in Chicago, IL. The Early Career Investigator Award is jointly organized with ANYL and MEDI. Thanks to Steve Silverman and Steve Wisniewski … Read More The post 2026 Early & Mid-Career …

Reductive sulfonamidation of ketones, previously impossible, was achieved using new 'diethylsilylium ion'

How to write a point-by-point response to reviewers for the Journal of the American Chemical Society, where a characterization request means new data in the Supporting Information, not a discussion paragraph, and the revision clock is short.