GEN – Genetic Engineering and Biotechnology News

Medicines Discovery Catapult provided its investment and expert support to help two biotech companies accelerate the development of new treatments for a range of autoimmune, inflammatory, and age-related diseases. The post Medicines Discovery Catapult Backs Two U.K. Biotech Companies Tackling Chronic Diseases appeared first on GEN - Genetic Engineering and Biotechnology News .

Researchers used a novel human 3D micro-bladder model to demonstrate how phage therapy could help to reduce recurrent urinary tract infections (UTIs) by attacking the reservoirs of bacteria hidden deep within the bladder wall, which antibiotics can’t address. The post Micro-Bladder Model Demonstrates How Phage Therapy Could Help to Reduce Recurrent UTIs appeared first on GEN - Genetic Engineering…

A new study from CHOP challenges the assumption that infant C. difficile colonization is harmless, finding that it can reshape the developing gut and immune system with potentially lasting health effects. The post <i>C. difficile</i> Have Lasting Effects on the Infant Gut, Challenging Long-Held Assumption appeared first on GEN - Genetic Engineering and Biotechnology News .

Venetoclax, a cancer drug that inhibits BCL-2, reduced the intact SIV reservoir in macaques, offering preclinical support for targeting BCL-2 as part of HIV cure strategies. The post Cancer Drug Reduces SIV Reservoir in Macaques, May Inform HIV Cure Strategies appeared first on GEN - Genetic Engineering and Biotechnology News .

The Flatiron Park facility in Colorado will serve as the Watchmaker Boulder Manufacturing Center of Excellence for reagent manufacturing and will house the company’s manufacturing, quality, R&D, and operations teams. The post Watchmaker Genomics Boosts Manufacturing Capacity with Major Boulder Campus Expansion appeared first on GEN - Genetic Engineering and Biotechnology News .

A study in mice traces immune cells that drive neurodegeneration to the body’s lymph nodes, suggesting that processes outside the brain contribute to the damage seen in various tauopathies. The post Immune Cells Driving Alzheimer’s-Like Neurodegeneration Traced to Lymph Nodes appeared first on GEN - Genetic Engineering and Biotechnology News .

A study found that psilocybin given before chemotherapy prevented the onset of nerve injury in mouse models, even after repeated treatment cycles, and also protected tumor-bearing mice from neuropathy, without impairing antitumor efficacy. The post Psilocybin Prevents Chemotherapy-Related Peripheral Neuropathy in Mice appeared first on GEN - Genetic Engineering and Biotechnology News .

Semaglutide improved health, reduced aging-related changes, and extended lifespan in older female mice, sometimes outperforming caloric restriction. However, human longevity benefits remain unproven. The post GLP-1 Drug Semaglutide Slows Aging and Extends Lifespan in Mice appeared first on GEN - Genetic Engineering and Biotechnology News .

Loss of function in the ALDH3B2 gene can convert human pancreatic duct cells into functional β-like cells that in tests secreted insulin in response to glucose, and lowered blood glucose levels when transplanted into diabetic mice. The post Converted Human Pancreatic Duct Cells Show Diabetes Therapy Potential appeared first on GEN - Genetic Engineering and Biotechnology News .

A new spectrometry technique could help companies better understand what happens when antigens and antibodies bind. Its developers hope it could help with applications including choosing formulation buffers during manufacturing. The post New Spectrometry Technique Could Aid Formulation Development appeared first on GEN - Genetic Engineering and Biotechnology News .

A new mathematical model tracks how plasmids move through competing E. coli populations, revealing how antibiotics, genetic costs, and plasmid loss could shape biotechnology cultures and future probiotic dosing strategies in the gut. The post Math Model Predicts Plasmid Power Struggles appeared first on GEN - Genetic Engineering and Biotechnology News .

To produce stable cell lines for monoclonal antibody production, manufacturers typically use the piggyBac transposon system. For larger, multi-specific antibodies that have payloads of three or four cistrons, piggyBac is only the starting point. The post Bicistornic Vectors + piggyBac = Improved Antibody Cell Line Production appeared first on GEN - Genetic Engineering and Biotechnology News .

Advances in technology are making it easier for biopharma companies to embrace continuous manufacturing. However, they are also changing what regulators expect from drug firms in terms of the process control strategies they use. The post Regulatory Demands for More Process Control Data Fueling Innovation appeared first on GEN - Genetic Engineering and Biotechnology News .

Researchers generated a single-cell atlas of the striatum, identifying 31 neuronal subpopulations and disease-linked vulnerabilities that could inform studies of Huntington’s disease, schizophrenia, depression, and substance use disorder. The post Single-Cell Striatum Atlas Reveals Neurological Disorder Vulnerabilities appeared first on GEN - Genetic Engineering and Biotechnology News .

TraceIQ, which was developed and being marketing by Systech, combines enterprise traceability, operational intelligence, and AI-assisted investigations to help manufacturers prevent disruptions, accelerate exception resolution, and improve product availability. The post TraceIQ Launched to Maximize Pharmaceutical Traceability appeared first on GEN - Genetic Engineering and Biotechnology News .

Under the agreement, Andelyn will transition Genprex's adeno-associated virus (AAV)-based diabetes gene therapy candidate with process optimization, scale-up, and IND-enabling and clinical-stage manufacturing to support clinical trials. The post Andelyn to Support Manufacturing Scaleup for Genprex’s Diabetes Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News .

Researchers showed how optical metabolic imaging (OMI) can be used to characterize metabolic activity within immune cells from the peripheral blood of patients, which could potentially help to improve disease diagnostics and the production of cell therapies. The post Advanced Imaging Technique Reveals Immune Cell Metabolic States in Blood Samples appeared first on GEN - Genetic Engineering and Bi…

Based in Cambridge, MA, Merida develops biologic drugs that are engineered to selectively degrade pathogenic autoantibodies linked to a number of immune-mediated conditions. Merida has said its precision degradation approach aims to address the biological cause of these diseases, rather than broadly suppressing the immune system as done by many current treatments. The post Lilly Looks Beyond Obes…

A new spatial transcriptomics framework compares tumor “floor plans." In a study of 262 solid tumors, the team identified recurring spatial groups that may connect spatial structure, biological function, and response to therapy. The post Spatial Transcriptomics Tools May Link Tumor Organization to Treatment Response appeared first on GEN - Genetic Engineering and Biotechnology News .

Researchers discovered an unexpected role for lysyl oxidase inside triple negative breast cancer cells, and demonstrated that blocking LOX disrupts cellular processes to create a weakness that can be exploited using a second drug. The post ‘One-Two Punch’ Targets Resistance Mechanism in Aggressive Triple-Negative Breast Cancer appeared first on GEN - Genetic Engineering and Biotechnology News .