drug-delivery

We celebrate an R² of 0.99 in drug release as a success. But classical models like Higuchi and Korsmeyer-Peppas are merely retrospective curve-fitting. In our latest paper, we introduce the D-PARMO framework to move from descriptive math to actual predictive clinical translation.

Getting a cancer drug to a tumor is only half the problem. Within hours of arrival, many therapeutics begin to drift, diluted by blood flow, expelled by pumps embedded in cancer cell membranes, or simply diffusing into surrounding healthy tissue before they’ve had a chance to work. The tumor, in other words, doesn’t hold onto them. And that failure of retention, more than anything else in drug de…

National University of Singapore Researchers at the National University of Singapore (NUS) have developed a high-throughput method to identify gold nanoparticles capable of delivering therapies directly to mitochondria (the energy centres inside cancer cells).

This Collection highlights the growing importance of hydrogels, liposomes, polymeric nanoparticles, and other soft materials in advancing targeted, controlled, and sustainable drug delivery systems. It is open for submissions with a submission deadline of 10 December 2026.

Prof. Vivian Feig et al present a design framework and then examine how it guides development of functional devices delivered as flowable precursors that then assemble into macroscopic, tissue-conformal devices at the target site, enabling minimally invasive implantation.

A practical Journal of Controlled Release submission guide for drug-delivery researchers evaluating their work against the journal's mechanism and translational bar.

Bacterial infections, especially those involving drug-resistant pathogens and biofilms, pose a severe global health threat. Conventional antibiotic therapies are limited by poor penetration, low specificity, and bacterial resistance mechanisms. Magnetic nanoparticles (MNPs) offer a promising alternative by combining magnetically guided targeting, magnetothermal/photothermal effects, multifunction…

Nature Communications, Published online: 15 April 2026; doi:10.1038/s41467-026-71806-0 Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

The standard of care for proliferative retinopathies, such as diabetic retinopathy and age-related macular degeneration, has long relied on invasive intravitreal injections. These direct-to-eye needle procedures are often painful and carry risks of infection or increased ocular pressure. However, a scientific breakthrough published in April 2026 by researchers at Wayne State University and Washin…

Kevin Jahnke Moves On to Independent Research February 26, 2026 We are delighted to share that Dr. Kevin Jahnke has departed the Weitz Lab to begin the next exciting chapter of his scientific career. During his time with us, Kevin made invaluable contributions to the lab’s research in membrane biophysics and drug delivery, engineering novel vehicles for the delivery...

Imagine a drug carrier you can watch as it moves, guide to a target, and then switch on at the right moment

The new company will advance targeted drug delivery in the brain with low-frequency focused ultrasound for blood-brain barrier opening.

Delivering therapeutic agents to the heart has long been a formidable challenge. While cardiovascular diseases remain the world’s leading cause of mortality, modern therapeutic strategies—including RNA medicines, protein drugs, and gene-editing tools—struggle to reach the myocardium in meaningful amounts. The heart’s unique structural and physiological barriers have historically limited the succe…

Abstract: The talk will explore the key challenges in the design and development of drug delivery systems aimed at targeted disease treatment. Special emphasis will be placed on strategies for crossing biological barriers, with a focus on targeting the brain, while also considering broader aspects of precision delivery, safety, and efficacy. The presentation will highlight current limitations, [&…

Neal Kassell, MD, writes about how focused ultrasound is being used to enhance drug delivery.

Key Points A recent paper highlights focused ultrasound’s flexibility as a platform for drug delivery to the brain. The publication, in the September 2024 edition of Nature Communications, demonstrated how focused ultrasound can be tuned to control the immune system’s response during blood-brain barrier (BBB) opening for therapeutic delivery. The researchers used advanced mathematical models and …

Lipid nanoparticles (LNPs) have emerged as one of modern medicine's most significant drug delivery systems.

For a long time, the poor solubility and low bioavailability of APIhave been a major problem for drug developers, and the low solubility has led to the limitation of its […]