The R² Illusion: Why Retrospective Curve-Fitting is Failing Nanomedicine Translation (And How D-PARMO Fixes It)
Akeem Adeyemi Oladipo
We celebrate an R² of 0.99 in drug release as a success. But classical models like Higuchi and Korsmeyer-Peppas are merely retrospective curve-fitting. In our latest paper, we introduce the D-PARMO framework to move from descriptive math to actual predictive clinical translation.