oncology

IntroductionPancreatic cancer remains a leading cause of death with poor prognosis. Current standard chemotherapies offer limited survival benefits, and no standard treatment exists for patients failing two lines of therapy. Preclinical evidence suggests that targeting MNK and VEGFR pathways can remodel the immunosuppressive tumor microenvironment and enhance immunotherapy efficacy. This study ev…

Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of hematopoietic stem cell transplantation in which systemic complement activation induces endothelial injury, leading to microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction. TA-TMA often progresses rapidly and has historically been associated with high mortality. Over the last deca…

Nature, Published online: 14 June 2026; doi:10.1038/d41586-026-01834-9 Lung cancer risk was higher in people who took up electronic cigarettes than in those who quit smoking completely.

Longer lifetime exposure to female hormones may increase the risk of thyroid cancer in women, according to a study being presented Saturday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.

Metastatic testicular germ cell tumours are highly curable, yet a small subgroup of patients deteriorates within days of treatment initiation. Our study focuses on these “super-high-risk” patients, in whom early recognition and rapid supportive care may determine survival.

Poolbeg Pharma to test the treatment in NHS hospitals and says it is also developing a GLP-1 weight loss pill A London-based startup is about to trial a drug at six NHS hospitals that could stop people on cancer immunotherapy getting a life-threatening side-effect. Poolbeg Pharma said its oral drug POLB 001 could make treatment for blood cancer safer by preventing cytokine release syndrome (CRS) …

As people age, changes slowly build up inside their cells. Every day, our cells divide, repair damage, and respond to the environment around them. During these processes, small mistakes can appear in DNA. These mistakes, known as mutations, become more common over time. Most of them are harmless, but some can affect how cells behave. […] The post Surprising Cancer-Like Changes in the Brain May Dr…

Longer lifetime exposure to female hormones may increase the risk of thyroid cancer in women, according to a study being presented Saturday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill. The research suggests reproductive and hormonal factors may be involved in thyroid carcinogenesis.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74061-5 Inhibition of PLK4 is synthetic lethal in cancers with chromosome 17q TRIM37 copy number gain. Here, the authors show that while RP-1664 (PLK4 inhibitor) causes centrosome depletion in a TRIM37-dependent manner as high doses, low dose causes cell death in a TRIM37-independent manner via centrosome amplification …

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74318-z Mechanisms underlying effective immune escape in HPV-associated oropharyngeal cancers despite the presence of immune cells are incompletely understood. Here, authors use single-cell spatial analysis to show that tumors form distinct local immune niches, including hypoxic regions and chemokine foci, that shape im…

Scientists at Florida International University may have found a way to make a powerful cancer treatment work even better. The treatment, called CAR-T therapy, uses a patient’s own immune cells to fight cancer. Doctors remove special immune cells called T-cells from the body, genetically change them in a lab so they can recognize cancer, and […]

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74384-3 The evolutionary changes in cancer genomes under treatment are not fully understood. Here, whole-genome sequencing of 58 single-cell tumoroids and 18 matched bulk tumours from 6 metastatic colorectal cancer patients reveals clonal structures and mutation patterns under therapy.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-73931-2 Bone metastases derived from lung cancer typically exhibit an immunosuppressive microenvironment. This study identifies a YBX1 glycosylation–dependent mechanism that drives both metastasis and immunosuppression, and proposes the small molecule Icaritin as a potential therapeutic strategy through YBX1 degradation.

Metastasis remains the leading cause of death in breast cancer, yet the mechanisms that allow disseminated tumor cells to evade immune surveillance remain poorly understood. We found that NCOR2 promotes metastasis by suppressing antigen presentation and limiting tumor recognition by CD8 T cells.

Doctors have long treated heart disease and cancer as two separate health problems. Heart specialists focus on the cardiovascular system, while cancer specialists focus on tumors and abnormal cell growth. However, scientists are increasingly finding that these two major diseases may be more closely connected than previously believed. A new study led by researchers at […] The post Could Your Heart…

New research co-led by Indiana University School of Medicine scientists presents a significant step toward more precise and effective cancer treatments by using a breakthrough method to deliver therapies directly to cancer cells. The study was recently published in ACS Nano. “One of the biggest challenges in cancer treatment is that many drugs not only […]

Researchers at the University of Illinois Chicago have developed an anti-cancer therapy inspired by bacteria found in cancer tumors. When tested in combination with radiation in animal models of prostate cancer, it was highly effective — the approach effectively shut down tumor growth. The therapy is made from a fragment of a bacterial protein, a […]