oncology

Detecting melanoma before it becomes visible is a major challenge in dermatology. Now, with researchers from Université de Montréal, scientists at Université du Québec's Institut national de la recherche scientifique (INRS) have developed a promising solution.

BackgroundBreast cancer patients are at an increased risk of insomnia, which can lead to emotional disorders, reduced quality of life, and potentially higher cancer mortality. Auricular acupuncture (AA) offers a feasible treatment option due to its short procedure time, low technical complexity, and relative safety. However, while preliminary studies suggest potential benefits of AA for treating …

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01806-9 Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer

Recently, a research team led by Professors Dahong Zhang and Qi Zhang from the Urology Department and the Institute of Urology at Zhejiang Provincial People's Hospital and the Translational Medicine Center discovered that a bladder tumor-targeting polyarginine peptide, R11, can directly bind to actin, destabilize the G-actin tetramer, and trigger the cascade breakdown of the actin-plectin-vimenti…

BackgroundPoorly differentiated squamous cell carcinoma (PDSCC) is an aggressive oral malignancy with rapid progression, high recurrence, and poor survival. This study aimed to evaluate the clinicopathological features, immunohistochemical expression of p63 and EGFR, and quality of life (QOL) in PDSCC compared to well-differentiated SCC (WDSCC).MethodsIn this retrospective observational study, 78…

GLP-1 drugs such as Ozempic, Wegovy, and Mounjaro have become widely known for helping people lose weight and control diabetes. Over the past few years, these medications have rapidly grown in popularity around the world. Many people take them to lower blood sugar, reduce appetite, and improve obesity-related health problems. Now, scientists are discovering that […] The post Popular Weight-Loss D…

When Abdominal Pain Was Neurologic: Acute Intermittent Porphyria Presenting as Posterior Reversible Encephalopathy Syndrome Adapted from "Acute intermittent porphyria presenting as posterior reversible encephalopathy syndrome: a case report." Journal of Medical Case Reports. 2026;20:278.

Scientists in South Africa are exploring a surprising new way to detect one of the world’s deadliest cancers: saliva. Researchers at the Sydney Brenner Institute for Molecular Bioscience at Wits University believe that bacteria living in the mouth may provide important clues about esophageal squamous cell carcinoma, a dangerous form of cancer that affects the […] The post Simple Saliva Test May H…

A new wave of scientific understanding is placing ferroptosis, a distinct form of iron-dependent cell death, at the forefront of efforts to overcome drug resistance in digestive cancers. These cancers, which include gastric, colorectal, liver, pancreatic, and esophageal malignancies, remain among the most challenging to treat due to their ability to evade standard therapies.

A newly published review article highlights the critical role of fatty acid metabolism in shaping the tumor microenvironment and influencing cancer progression, offering fresh perspectives for the development of more effective therapies.

A new review brings attention to the STING pathway as a critical regulator in both colitis and colon cancer, highlighting its complex and often opposing roles in inflammation and tumor development. The findings underscore how this key component of the innate immune system can act as both a driver of disease and a protective mechanism, depending on biological context.

A new review article highlights the expanding importance of glutamine metabolism in shaping the tumor microenvironment, offering fresh perspectives on how metabolic interactions influence cancer progression and therapeutic response

Substantial and sustained weight-loss has been linked to a reduced risk of cancer and cancer-related death, mainly in women. Two new studies now provide clues to why the risk is reduced - and suggest that gender, metabolism and genetics may play a crucial role.

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01829-2 Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication

Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73562-7 While first-line immunochemotherapy has shown efficacy in patients with extensive-stage small-cell lung cancer (ES-SCLC), survival benefit is limited. Here, the authors report a phase II randomised clinical trial comparing durvalumab (anti-PD-1) plus anlotinib (multi-TKI) against durvalumab alone as maintenance t…

BackgroundHuman papillomavirus 33 (HPV33) is among the five most prevalent HPV genotypes in China and is commonly involved in co-infections. However, the synergistic effects of specific genotype combinations on cervical carcinogenesis remain incompletely understood. This study aimed to characterize HPV33 co-infection patterns and their associated genetic variations in relation to cervical lesion …