structural-biology

Inside every cell, thousands of proteins must reach the right place at the right time. Helping coordinate this complex logistics network are centriolar satellites-tiny, membrane-less organelles that play important roles in protein trafficking, cell division, and the formation of cilia.

Researchers at the University of Cologne, University Hospital Cologne, and the Max Planck Institute for Metabolism Research have developed a method that, for the first time, enables damage to individual cells to be precisely quantified.

A new study provides an exquisitely detailed map of the circuitry of the fovea, the minute structure in

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-76193-0 Here, authors solve three cryo-EM structures of EcMscL in two different lipid environments and two distinct conformational states; closed and open-like, guided by EPR. Additional EPR, MD and HDX-MS experiments provide insight into the gating mechanism.

The mini-brains are full of surprises The post The Remarkable Lives of 5-Year-Old Brain Organoids appeared first on Nautilus .

Researchers kept human brain organoids developing for over five years, revealing prolonged maturation that mirrors human brain development and creating new opportunities to study disorders and test drugs. The post Five-Year Brain Organoids Reveal New Insights Into Human Development appeared first on GEN - Genetic Engineering and Biotechnology News .

Whether you are characterizing cell state transitions, assessing organelle integrity, or building a multiplex immunofluorescence (IF) assay, you need reliable structural markers for your imaging.

A new Northwestern Medicine study has uncovered key molecular design principles that could help supramolecular therapeutics cross the blood-brain barrier, a major challenge for this novel approach to treating neurological disorders. Published in ACS Nano, the study examined how subtle changes in the structure of molecules called peptide amphiphiles affect their ability to move through […]

Scientific Reports, Published online: 21 August 2026; doi:10.1038/s41598-026-61005-8 Facial soft tissue changes following anterior maxillary rehabilitation with different prosthetic concepts assessed using three-dimensional stereophotogrammetry

Nature Communications, Published online: 21 August 2026; doi:10.1038/s41467-026-76928-z Authors identify the TANC complex, comprising TTC33, WDR61 and PHF5A, and show that it nucleates a protein interaction network containing factors implicated in splicing and DNA repair. Its disruption promotes genomic instability.

This is the only paper in the entire literature of alveolar morphometry which describes the difference between chord length and mean linear intercept, and details a step-by-step method to download and install our customized plugin for measuring chord length on lung sections of different animal model

Tabea C. Fricke, Ruth A. Pumroy, Julia A. Rocereta, José J. De Jesús-Pérez, George Oprita, Marvin J. A. Meyer, Christine Herzog, Frank G. Echtermeyer, Kerstin Hill, Andreas Leffler & Vera Y. Moiseenkova-Bell Nature Communications   Abstract Transient receptor potential vanilloid 2 (TRPV2) is a broadly expressed ion channel implicated in diverse physiological and pathological processes. … Continue…

The Arctic whales are the only known animals with straight tusks, and ones that consistently twist to the left. New research reveals that the inner layer twists to the right and that the opposing spirals provide strength and help the tusks grow straight

Nature Communications, Published online: 20 August 2026; doi:10.1038/s41467-026-76904-7 The molecular mechanisms underlying protein condensation remain poorly understood. Here the authors discover and characterise the dynamic condensation of citrate synthase in C. glutamicum, showing condensation is dependent on catalytic activity and substrate binding.

Nature Communications, Published online: 20 August 2026; doi:10.1038/s41467-026-76925-2 Cryo-EM, NMR, and MD simulations reveal how charybdotoxin (CTX) binds to the MthK potassium channel, identifying key residues that stabilize toxin binding and block potassium ion conduction

DNA topoisomerase-IA is an essential enzyme that relaxes supercoiled DNA by introducing transient single-strand breaks through a covalent phosphorylated tyrosine (PTR) intermediate. This cleavage occurs when the active-site tyrosine of dTopo-IA forms a covalent bond with the DNA phosphate backbone, resulting in PTR formation. Although dTopo-IA is believed to mediate strand passage via an enzyme-i…

Bones are living tissues that constantly rebuild, repair and help the body stay in balance.

Many small animals make their teeth and claws from a smooth blend of proteins and heavy elements. These materials can form very sharp tools that make it possible to cut tough substances using tiny muscles.