Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection
Patrick Sung
Nature Communications, Published online: 20 May 2026; doi:10.1038/s41467-026-73479-1 PDS5B, a cohesin regulatory protein, is shown to bind DNA and enhance the RAD51 recombinase in the promotion of DNA strand exchange and protection of DNA from MRE11 RAD50-NBS1. Here the authors use biochemical and cellular analyses to reveal that DNA binding by PDS5B is essential for DNA damage repair and the preservation of stressed DNA replication forks.