Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart
Timothy Grant
Nature Communications, Published online: 16 May 2026; doi:10.1038/s41467-026-73239-1 Restart of failed DNA replication processes is essential but poorly understood. Here, the authors present cryoEM structures of two preprimosome complexes, revealing how the PriA/PriB/DnaT complex assembles and matures. The findings suggest a possible DnaA-like mechanism for replisome recruitment.