cancer

A new wave of scientific understanding is placing ferroptosis, a distinct form of iron-dependent cell death, at the forefront of efforts to overcome drug resistance in digestive cancers. These cancers, which include gastric, colorectal, liver, pancreatic, and esophageal malignancies, remain among the most challenging to treat due to their ability to evade standard therapies.

A new review brings attention to the STING pathway as a critical regulator in both colitis and colon cancer, highlighting its complex and often opposing roles in inflammation and tumor development. The findings underscore how this key component of the innate immune system can act as both a driver of disease and a protective mechanism, depending on biological context.

A new review article highlights the expanding importance of glutamine metabolism in shaping the tumor microenvironment, offering fresh perspectives on how metabolic interactions influence cancer progression and therapeutic response

Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People's Hospital, published a review entitled "Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer".

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite.

When Pat Gentile began to grow out her hair after chemotherapy, she was nervous to go to work for the first time without a wig. An unexpected encounter with a convenience store stranger changed that.

_Sitting with a Madmind : Prelude Trilogy_. forthcomingThis paper proposes that a single structural pathology — captured resonance — recurs across multiple scales of biological organization, with consistent defining features and a consistent recovery geometry at each scale. The argument is supported by three instantiations: cancer at the cellular and tissue scale, with the Soto-Sonnenschein tissu…

Alistipes, a bacterial genus under phylum Bacteroidetes, widely colonizes the gut. Since the first report of Alistipes in 2003, 13 species and 3 subspecies have been successfully isolated and identified from human feces, urine, appendiceal lesions, and rectal abscesses. Alistipes was reported to enhance the efficacy of immunotherapies in cancer treatment, while the detailed descriptions of other …

University of Virginia School of Medicine scientists have revealed how mistakes in the final step of cell division can have dire consequences for developing brain cells.

Glioblastoma is a highly lethal brain tumor, and its outer edges are unexpectedly more viscous than its core. This physical gradient forces tumor cells to push through increasingly thicker fluid as they invade healthy tissue. Researchers have now built an open microfluidic chip that captures this unique mechanical challenge

When cancer spreads beyond its original location, treatment becomes much more difficult. Doctors often depend on imaging scans like CT scans and MRI scans to see where tumors have moved and how large they are. But scans cannot always detect every cancer cell, especially in the early stages of spread. A new international study now […] The post New DNA blood test could help doctors track and treat …

Nature Immunology, Published online: 19 May 2026; doi:10.1038/s41590-026-02505-7 In this Resource paper, Krummel and colleagues provide analysis of 15 commonly used syngeneic mouse tumor models and compare these to the diversity of human tumor microenvironments.

Pancreatic cancer is one of the most lethal cancers, with only 11% five-year survival. Tumour heterogeneity is a key reason: cells within the same tumour behave differently. Here we present a single-cell dataset of 31,000 cells from 41 patient-derived cultures, freely available.

BackgroundThe crotonylation reader DPF2 has been implicated in tumor progression, but its role in colon adenocarcinoma (COAD), especially in cell-type-specific immune regulation and metabolic reprogramming, remains unclear.MethodsWe conducted an integrative multi-omics study combining genetic association analysis for COAD, public transcriptomic validation data, CRC-context single-cell and spatial…

A protein best known for driving cancer growth also helps damaged tumor cells survive by repairing their DNA, according to a new study that could influence how some cancers are treated.

A casual conversation between graduate students helped spark a breakthrough in aging research at Mayo Clinic. Researchers discovered that tiny synthetic DNA molecules called aptamers can selectively attach to senescent “zombie cells,” which are linked to aging, cancer, and neurodegenerative disease. The method could eventually help scientists identify and target these cells in living tissue with …

What if cancer cells are using a signaling shortcut we've been missing? Scientists uncovered a mechanism in a key cell-to-cell communication system--insight that could point to more effective therapies.