cancer

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-76998-z Sex hormones and cancer-cell sex influence tumor growth, but other sex-dependent drivers of oncogenesis remain unclear. Here, the authors reveal that the sex of central neurons alters the peripheral tumor-supportive niche to promote tumor growth.

A long-running study suggests that chemicals formed during drinking water disinfection may play a role in uterine cancer risk. Scientists tracked more than 53,000 California teachers and school administrators for nearly two decades and found that women exposed to higher levels of certain water treatment byproducts were more likely to develop uterine cancer. The findings […] The post Can Tap Water…

Ribophorin I (RPN1), a core component of the oligosaccharyltransferase complex, is traditionally known for its role in endoplasmic reticulum-associated N-glycosylation. Recent studies have identified RPN1 as an emerging regulator of tumor progression and immunity. Aberrant RPN1 overexpression has been reported in multiple malignancies, including glioma, hepatocellular carcinoma, sarcoma, and trip…

In a new study, scientists from Johns Hopkins Medicine report that an experimental mRNA-based platform has the potential to help deliver next-generation mRNA therapeutics, including vaccines fighting against infectious disease, cancer and autoimmune conditions, faster and more efficiently than the industry standard.

IntroductionRegulated cell death (RCD) pathways influence tumor progression and immune modulation. We previously constructed a signature database mapping 25 RCD forms across seven multi-omic layers and 33 tumor types (CancerRCDShiny). Despite their ability to identify risk populations, translating these signatures into personalized clinical workflows requires a shift from cohort stratification to…

In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, PhD, associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys Medical Discovery Institute, establish a unified framework that governs one of cancer's most powerful master regulators.

Screening newborns for cancer risk Blood samples routinely collected at birth could be used for genetic testing, potentially helping 1,000 children a year, st... #health, #cancer, #healthcare, #research, #genetics, #supereducational

Researchers at Washington University School of Medicine in St. Louis have discovered lymph node-like structures in the skull bone marrow of mice for the first time and demonstrated that they act as rapid first responders against brain cancer before distant lymph nodes get the signal that abnormal cells are present. The researchers also found evidence of similar immune cells in human skull bone ma…

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains one of the leading causes of cancer-related deaths worldwide. Despite advances in targeted therapies and immunotherapy, substantial molecular heterogeneity continues to limit accurate prognostic prediction and effective treatment selection. While metabolic reprogramming is increasingly recognized as a hallm…

Nature Communications, Published online: 15 August 2026; doi:10.1038/s41467-026-76757-0 Trained immunity results in improved secondary response to stimulus in innate immune cells. Here the authors show that trained immunity in macrophages establishes a mitochondrial glutamine-restriction metabolic checkpoint and explore its role in a murine model of tumor immunity.

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