Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter
Ming-Feng Tsai
Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73711-y Cells prevent the mitochondrial Ca2+ uniporter from causing Ca2+ overload and cell death by expressing the non-conductive regulator MCUb. Here, the authors rebuild Ca2+ conductance in MCUb, revealing the molecular basis of its regulatory function.