psychiatry

If a small stroke in one corner of the brain can tip a previously healthy person into mania or set off obsessions and compulsions where none existed before, then the circuit connected to that lesion is telling us something rare in psychiatry.

IntroductionIn the treatment of schizophrenia, antipsychotics used during acute inpatient care must control acute symptoms while remaining sufficiently tolerable to support treatment beyond the acute phase. Brexpiprazole, a serotonin-dopamine activity modulator may be one such option; however, its real-world use and short-term continuation in acute inpatient settings remain insufficiently charact…

People living with severe mental disorders such as schizophrenia and bipolar disorder are routinely offered treatment aimed at reducing symptoms and improving daily functioning. Yet ... Read more

Panic attacks can feel overwhelming and out of control. People who experience them often describe a sudden wave of fear, along with physical symptoms like a fast heartbeat, shortness of breath, and dizziness. These attacks can happen without warning and can make everyday life very difficult. Although there are medications available, they do not work […] The post Small dose of antibiotic could hel…

Source: Science Daily - Top Health A new study suggests depression may soon be detectable through a simple blood test that tracks how certain immune cells age. Researchers found that aging in monocytes—a type of white blood cell—is closely tied to the emotional and cognitive symptoms of depression, like hopelessness and loss of pleasure, rather than physical symptoms such as fatigue. The study wa…

Researchers from University of California San Diego have found that microdosing - taking very small amounts of psychoactive substances - is more common among U.S. adults than previously recognized, with cannabis leading by a wide margin.

Older adults often experience a sharp increase in depressive symptoms in the final years of life. New research reveals this "terminal decline" accelerates about four years prior to death, with men experiencing steeper mood drops than women.

For BPD Awareness Month, a look at how far the field has come: BPD is now one of the most treatable conditions in psychiatry—and the care is getting more accessible.

Weill Cornell Medicine investigators have "reverse engineered" ketamine's antidepressant effects to identify potential new strategies for treating depression.

Poststroke anxiety and depression (PSAD/PSAnx) are common and heterogeneous emotional disorders among stroke survivors, significantly impacting functional recovery, quality of life, and long term prognosis. Their pathogenesis is complex and multifactorial, involving neurobiological alterations, cognitive dysfunction, behavioral responses, and social environmental factors. Cognitive impairments, f…

IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and cerebral spinal fluid (CSF) autoantibodies with other routine and novel markers of neuroinflammation, including CSF cytokines in patients with atypical psychiatric presentations of…

BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons, which results in motor issues such as tremors, stiffness, and slowness of movement. In addition to experiencing non-motor symptoms like psychosis. Catatonia, a psychomotor syndrome that is resulted from dopamine and cerebral cortical dysfunction, is considered a rare manifes…

IntroductionTic disorders (TDs) are common neurodevelopmental conditions with unclear pathogenesis and a lack of objective biomarkers. This study aimed to explore the associations among circulating microRNAs (miRNAs), erythroid phenotypes, iron homeostasis, and pediatric TD.MethodsA total of 30 TD children and 10 healthy controls were enrolled. Serum levels of five candidate miRNAs, erythroid par…

IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure patterns, differ across dementia subtypes among older adults with both conditions.MethodsWe analysed anonymised electronic health records from a south London catchment area. We inclu…

ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.MethodsElderly patients with depressive disorder and OSAHS were consecutively enrolled from January to December 2025. A Gower distance matrix was constructed and phenotypes were deriv…

BackgroundSleep problems, including daytime sleepiness, short sleep duration, and poor sleep quality, are strongly associated with suicidality in non-autistic people. Sleep difficulties are also common in Autistic children and adolescents (herein, youth), affecting 40-80%, and may contribute to their elevated suicide risk, which emerges as early as 10 years of age and is 3.5 times higher than the…

GLP-1 drugs like semaglutide—best known for treating diabetes and driving weight loss under the brand names Ozempic and Wegovy—may also deliver a surprising mental health boost. In a massive study tracking nearly 100,000 people over more than a decade, researchers found that these medications were linked to significantly fewer psychiatric hospital visits and sick days.

Drugs designed to clear amyloid beta from the brain—once seen as a promising path to slowing Alzheimer’s—may not actually help patients in any meaningful way, according to a major review of over 20,000 participants. Even more concerning, they may increase the risk of brain swelling and bleeding, sometimes without obvious symptoms.

Medicines that affect the brain, such as antipsychotics and certain sleep drugs, are widely used in older adults. These drugs can sometimes help with symptoms like anxiety, sleep problems, or agitation. However, they can also cause serious side effects, especially in people with memory problems or dementia. A new study from researchers at the University […] The post Why many older people stick to…