Nature Medicine

Nature Medicine, Published online: 22 May 2026; doi:10.1038/d41591-026-00027-1 A rare case of genomic integration of an adenovirus vector led to a child developing a tumor — successfully removed by surgery — which highlights the importance of long-term safety monitoring in patients who receive gene therapy.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-y Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04416-4 At week 68, in patients who experienced poor weight loss following bariatric surgery, semaglutide was associated with 18.0% weight loss compared to 0.4% weight gain in patients receiving placebo.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04456-w Naming in medicine: how disease nomenclature shapes diagnosis, research and patient lives

Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04413-7 Housing is not just a backdrop to health, but a powerful intervention. A study now shows that redesigning the home environment can improve child health outcomes, but success requires community co-design and solutions for cost and scalability.

Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04430-6 This Review surveys the fast-developing landscape of CAR T cells in autoimmune disease from both a technological and clinical standpoint, exploring the concept of deep B cell depletion and immune ‘reset’.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04384-9 The authors examine the vaccine landscape through two key areas of research and development—expanding target populations, and emerging vaccine technologies—and discuss cross-cutting issues, including the societal value of vaccines, funding and access, and regional manufacturing.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04374-x Women are now at the very center of the global cancer control agenda, but there are major challenges ahead.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04351-4 This Review discusses global approaches to infectious disease analysis and modeling, focusing on federated methods and addressing long-standing challenges in data interoperability, equity and trust.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04443-1 This special issue focuses on the challenges and opportunities for curtailing the global burden of infectious diseases in a fragmented, conflict-prone world.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04377-8 This Review examines how climate variables affect pathogen transmission, seasonality and outbreak patterns, how these interact with weather extremes and demographic change, and how current data streams can be leveraged to understand future disease trajectories.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04424-4 Using large-scale retinal images from community and tertiary hospitals, we developed Reti-Pioneer, a quality-aware, multi-task framework for multi-disease detection. Diverse external validation confirmed its generalizability. Furthermore, a prospective silent trial and clinical pilot study demonstrated its time efficie…

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04423-5 Analyses of sequencing data from 75,602 children referred for genetic testing from 2016 to 2025 provide insights on the association between pathogenic germline variants and childhood cancer.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04417-3 Unintended consequences of legacy oversight in digital medicine

Nature Medicine, Published online: 19 May 2026; doi:10.1038/d41591-026-00026-2 The portable, low-resource MiniDock MTB test, evaluated across multiple countries, shows promise for detecting pulmonary tuberculosis using sputum and tongue swabs.

Nature Medicine, Published online: 19 May 2026; doi:10.1038/s41591-026-04398-3 In a prospective cohort of 166 participants (and in a 63-participant validation cohort), dermal α-synuclein and 4-repeat tau seed amplification, combined with serum neurofilament light chain assays, were able to identify parkinsonian syndromes.

Nature Medicine, Published online: 18 May 2026; doi:10.1038/s41591-026-04396-5 In this World View, Ali T. Taher explains why thalassemia is a stress test for fragile health systems.

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04412-8 What Galen’s dissections reveal about tacit learning in modern medical education

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04402-w An open-label, randomized controlled phase 2 trial comparing favipiravir with ribavirin for the treatment of mild-to-moderate Lassa fever in Nigeria found that favipiravir was safe and well tolerated and supports its further optimization as a treatment alternative.

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04410-w Part of the Hong Kong Genome Project, genomic analyses of more than 20,000 participants provide information on clinically relevant variants for the Chinese population and offer insights on the implementation of genomic medicine initiatives.