Nature Medicine

Nature Medicine, Published online: 21 August 2026; doi:10.1038/s41591-026-04524-1 A new study offers the first systematic test of whether DNA methylation clocks behave the way a surrogate endpoint for aging should, responding to genuine clinical benefit and remaining stable when there is none.

Nature Medicine, Published online: 21 August 2026; doi:10.1038/s41591-026-04588-z Traditional medicine is already used by billions worldwide. Researchers, regulators and the World Health Organization (WHO) are now working to generate acceptable evidence, win regulatory acceptance, and integrate traditional medicines into modern clinical care.

Nature Medicine, Published online: 21 August 2026; doi:10.1038/s41591-026-04571-8 The largest multiomic atlas of the adult human hippocampus identifies disrupted neurogenesis, gene regulation and neural circuits in major depressive disorder, revealing molecular pathways and potential therapeutic targets related to stress, cellular aging and neuroplasticity.

Nature Medicine, Published online: 21 August 2026; doi:10.1038/s41591-026-04562-9 The responsiveness of 16 different epigenetic aging clocks to a broad array of pharmacological and lifestyle interventions in humans was assessed across 51 different longitudinal studies, providing insights into the potential of aging clocks to serve as reliable aging biomarkers.

Nature Medicine, Published online: 21 August 2026; doi:10.1038/s41591-026-04597-y A feasibility trial delivering psilocybin-assisted therapy for treatment-resistant depression within the UK health service reports encouraging adherence and safety — it opens future questions about who is reached, where treatment happens and what standards will be needed to sustain it.

Nature Medicine, Published online: 20 August 2026; doi:10.1038/d41591-026-00041-3 An ‘off-the-shelf’ vaccine that targets mutant KRAS can safely and durably activate T cell responses in healthy people at high risk of developing pancreatic cancer, according to a phase 1 study.

Nature Medicine, Published online: 20 August 2026; doi:10.1038/s41591-026-04612-2 A nationwide analysis of measles vaccination records from more than 50,000 US schools shows that measles transmission risk crossed the threshold that can lead to epidemics at the school level in the 2–3 years before the 2025–2026 outbreaks, whereas county-level estimates always remained below that threshold.

Nature Medicine, Published online: 19 August 2026; doi:10.1038/s41591-026-04624-y The emergence and spread of drug resistance threatens progress toward malaria control and elimination. We identified a rapidly spreading haplotype on chromosome 7 of Plasmodium falciparum that contains mutations and deletions in the px1 gene. This genomic locus is strongly associated with reduced susceptibility of P…

Nature Medicine, Published online: 19 August 2026; doi:10.1038/s41591-026-04600-6 The Global Neurosurgical Study-1 (GNS-I), conducted across 100 hospitals in 29 countries, found substantial variation in the causes of traumatic brain injury and in associated mortality outcomes across Human Development Index tiers.

Nature Medicine, Published online: 19 August 2026; doi:10.1038/s41591-026-04601-5 A pilot implementation study of a large language model clinical decision support system in a tertiary emergency department showed safe integration but steadily declining clinical adoption over 4 weeks.

Nature Medicine, Published online: 19 August 2026; doi:10.1038/s41591-026-04586-1 Dronabinol, the pharmaceutical form of Δ9-tetrahydrocannabinol, shows promise in the treatment of nightmares related to post-traumatic stress disorder (PTSD), but additional studies are needed to confirm safety and efficacy.

Nature Medicine, Published online: 19 August 2026; doi:10.1038/s41591-026-04589-y Liver DiagnOsis Network (LiON), a contrast-enhanced-computed tomography-based AI system that supports flexible multiphase processing, clinical data integration and workflow-compatible liver malignancy diagnosis, may help reduce missed or delayed diagnoses and guide clinical interventions.

Nature Medicine, Published online: 18 August 2026; doi:10.1038/s41591-026-04591-4 Food is medicine: an opportunity to transform nutrition care in oncology

Nature Medicine, Published online: 18 August 2026; doi:10.1038/s41591-026-04561-w Multiscale modeling shows that measles transmission at the school level in the United States crossed the epidemic threshold after 2022−2023, a shift not detectable by county-level or district-level surveillance.

Nature Medicine, Published online: 17 August 2026; doi:10.1038/s41591-026-04590-5 Whole-genome sequencing of clinical isolates of Plasmodium falciparum in Uganda reveals rapid selection of a PX1-associated haplotype linked to reduced susceptibility to commonly used antimalarials.

Nature Medicine, Published online: 14 August 2026; doi:10.1038/s41591-026-04575-4 In this Comment, we outline the Nordic AI-Health Initiative platform, built on unique large-scale longitudinal and multimodal health data sets from across the region. The platform is designed to enable secure, regulation-compliant access and to deliver generalizable models for responsible AI-driven discovery in medi…

Nature Medicine, Published online: 14 August 2026; doi:10.1038/s41591-026-04566-5 Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to develop aging clocks that reflect tissue structural integrity and organ-level physiological fitness in health and disease.

Nature Medicine, Published online: 14 August 2026; doi:10.1038/s41591-026-04576-3 Reconstructing disease burden data in armed conflict

Nature Medicine, Published online: 13 August 2026; doi:10.1038/d41591-026-00040-4 A new generation of clinical decision support tools is moving into practice, reshaping how evidence is generated, evaluated and used.

Nature Medicine, Published online: 13 August 2026; doi:10.1038/s41591-026-04595-0 Manipulating biology in the physical world is complex; the authors envision an AI-driven digital organism—a system of integrated multiscale foundation models—detailing how to construct and use such a model to advance biological and medical research.