Nature Medicine

Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04621-1 The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health.

Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04642-w In the randomized phase 2 ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma (MM) showed higher rates of complete clinical responses in response to treatment with teclistamab compared with lenalidomide–dexamethasone, although longer follow-up is required to determine durable prevention of prog…

Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04635-9 A 15-year cohort study shows that Alzheimer’s dementia risk is jointly shaped by Alzheimer’s pathology and cognitive resilience, with high resilience linked to lower risk, even under greater pathology.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04695-x A suite of large pre-trained language models accurately extracts computable clinical data from unstructured electronic health records and integrates the findings into knowledge graphs that can facilitate understanding patient trajectories and treatment responses in the real world.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04702-1 Author Correction: Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04640-y This large, population-based analysis shows that both pre- and post-ICI COVID-19 mRNA vaccinations were associated with modest early improvements in overall survival, primarily within the first few months, although similar patterns with other vaccines suggest non-specific effects rather than a vaccine-specific be…

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04602-4 An in-depth phenomic analysis of health and disease patterns from 1.9 million participants of the Our Future Health cohort reports the prevalence of health conditions and medication-use patterns compared with national UK estimates and the UK Biobank.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04703-0 CRISP, a vision-based pathology foundation model developed exclusively from frozen section slides, supports treatment decision-making throughout the surgical workflow with superior performance to current foundation models and extensive validation, including in a prospective cohort.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04572-7 In a phase 1 trial evaluating intravenous delivery of a next-generation CD3×CD19 bispecific T cell engager in patients with active systemic lupus erythematosus, treatment was well tolerated, and there were improvements in disease activity scores for most patients.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04631-z The transition from AI-assisted tools to more integrated, AI-native models of care requires workflow integration, clinician engagement and measurable clinical value.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04596-z An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed.

Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04634-w The Value Cube: translating clinical benefit into realizable value in global oncology

Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04678-y Author Correction: Ablation of TRIP-Br2 , a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04685-z As the availability of clinical trial data continues to lag behind, other forms of evidence generation leveraging real-world data and citizen science need to be considered to improve women’s health.

Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04647-5 Consensus framework for the validation of generative AI: call for collaborators on the Validation Accords

Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04615-z In a phase 2 randomized clinical trial, treatment with the myeloperoxidase (MPO) inhibitor mitiperstat, intended to target the neutrophil–MPO inflammatory pathway, did not improve symptoms or exercise function in individuals with heart failure with preserved or mildly reduced ejection fraction.

Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04607-z Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid.

Nature Medicine, Published online: 08 September 2026; doi:10.1038/s41591-026-04641-x A binding ban, and its limits: Japan legislates on heritable human genome editing

Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04633-x The first generation of medical artificial intelligence (AI) was judged on whether algorithms could match clinicians. The next generation should be judged on whether carefully designed human–AI systems can improve patient outcomes.

Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04645-7 Strengthening clinical trial ethics and regulatory oversight in Africa: lessons from the TRACE initiative