Nature Medicine

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04421-7 The Hong Kong Genome Project established a genome sequencing database that provides improved diagnoses for patients and more efficient, population-tailored carrier status screening. Actionable pharmacogenomic variants were identified in almost all participants, informing drug prescriptions. This work establishes a gen…

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04465-9 Pramipexole, in patients with major depressive disorder, dysthymia or bipolar depression, reduced Snaith−Hamilton Pleasure Scale scores significantly compared to placebo.

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04431-5 In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04409-3 We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amylo…

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04510-7 Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda

Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04444-0 Announced in this Comment and in collaboration with Nature Medicine is the convening of the Brain Health for Economic Resilience Commission, a global, transdisciplinary effort to define, measure and operationalize brain health and cognitive capacity as foundational drivers of economic resilience.

Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04436-0 Phase 1 results reveal that BBM-P002, a dual-target gene therapy co-delivering TH and DDC, is safe and well tolerated in Parkinson’s disease, with 12-month motor improvements signaling therapeutic potential.

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04429-z An interim report of a first-in-human phase 1 trial found an adjuvanted, combination inactivated rabies-vectored, Lassa fever vaccine (LASSARAB + 3D-6-acyl PHAD-SE) to be safe and induced immunogenicity to both Lassa and rabies viruses in healthy participants.

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04482-8 Bundibugyo Ebola without vaccines or therapeutics: why public health fundamentals matter more than border closures

Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04440-4 In the phase 2 EMBRAZE study, participants receiving tirzepatide and apitegromab lost less lean mass compared to participants receiving tirzepatide and placebo.

Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04469-5 A nationwide retrospective analysis of 4.5 million Korean adults found that electronic cigarette use after smoking cessation was associated with higher lung cancer incidence and mortality compared with complete smoking cessation.

Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04439-x In a whole-exome sequencing analysis, the beneficial effects of the SGLT2 inhibitor dapagliflozin in reducing the risk of future heart failure hospitalization in individuals with type 2 diabetes were markedly greater in individuals who carried a cardiomyopathy-associated genetic variant compared with noncarriers, sugg…

Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04428-0 In the randomized, double-blind phase 3 ALTAIR trial, patients with resected colorectal cancer who became positive for circulating tumor DNA during post-adjuvant surveillance received trifluridine/tipiracil hydrochloride therapy, which did not significantly prolong disease-free survival compared with placebo.

Nature Medicine, Published online: 07 June 2026; doi:10.1038/s41591-026-04479-3 As presented at the American Diabetes Association Meeting, in this phase 3 trial, weekly subcutaneous injections of survodutide, a glucagon receptor/GLP-1R dual agonist, lowered liver fat content and body weight compared to placebo in adults with obesity and at-risk metabolic dysfunction-associated steatotic liver dis…

Nature Medicine, Published online: 05 June 2026; doi:10.1038/s41591-026-04476-6 As presented at the American Diabetes Association Meeting: this randomized phase 2b trial in 230 adults with overweight or obesity shows that aleniglipron, an oral small-molecule GLP1-RA, led to up to 11.3% body-weight loss compared with placebo after 36 weeks of treatment.

Nature Medicine, Published online: 05 June 2026; doi:10.1038/d41591-026-00030-6 From artificial intelligence-enhanced scans to drugs that target the immune system, inflammation is emerging as a key driver of cardiovascular risk — and clinicians are learning to detect and treat it.

Nature Medicine, Published online: 04 June 2026; doi:10.1038/s41591-026-04422-6 A randomized controlled trial integrating Purrble, a socially assistive tactile robot, into safety planning found that LGBTQ+ youth at risk of self-harm experienced improvements in Difficulties in Emotion Regulation Scale and fewer depressive symptoms compared to safety planning alone.

Nature Medicine, Published online: 04 June 2026; doi:10.1038/s41591-026-04441-3 After preclinical testing, a phase 1 trial involving three individuals with familial hypercholesterolemia demonstrated preliminary evidence for the safety and efficacy of AAV8-mediated LDL receptor gene therapy.

Nature Medicine, Published online: 04 June 2026; doi:10.1038/s41591-026-04435-1 In this feasibility clinical trial, the authors show that epidural stimulation of the cervical spinal cord safely improved strength, function and spasticity in seven people with arm hemiparesis.

Nature Medicine, Published online: 04 June 2026; doi:10.1038/s41591-026-04393-8 Microglia cellular changes underlie divergent resilience-associated mechanisms in human aging.