Nature Medicine

Nature Medicine, Published online: 05 May 2026; doi:10.1038/s41591-026-04425-3 Author Correction: Benralizumab versus placebo for hypereosinophilic syndrome: a randomized, placebo-controlled phase 3 trial

Nature Medicine, Published online: 05 May 2026; doi:10.1038/s41591-026-04403-9 The agentic artificial intelligence tool SPARK is able to reproduce pathology-based reasoning and produce biological hypotheses and relevant diagnostic, prognostic and predictive cellular parameters. The output of SPARK has the potential to advance the understanding of tumor biology and enable the development of diagno…

Nature Medicine, Published online: 05 May 2026; doi:10.1038/s41591-026-04437-z Comprehensive, multinational validation of the PREVENT and SCORE2 cardiovascular risk scores, used in the United States and Europe, respectively, in 44 observational studies and 18 randomized trials, shows similar performance for the two risk scores and generally good performance across geographical regions.

Nature Medicine, Published online: 04 May 2026; doi:10.1038/s41591-026-04375-w An international and independent scientific foundation for AI governance

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04343-4 A nine-protein plasma signature is predictive of kidney events and mortality in individuals with a high-risk APOL1 genotype and preserved estimated glomerular filtration rate, outperforming existing clinical and genetic risk tools and providing a biologically plausible marker set for early intervention and trial enrich…

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04387-6 Integrating clinical data with simple physiological measures or biomarkers improves triage of febrile children and could reshape frontline care in resource-limited settings.

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04373-y Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems

Nature Medicine, Published online: 30 April 2026; doi:10.1038/d41591-026-00025-3 After years of limited options, a surge of targeted therapies — from immunomodulators to genetically defined drugs — is starting to reshape treatments for kidney disease.

Nature Medicine, Published online: 30 April 2026; doi:10.1038/d41591-026-00024-4 Indoor air purifiers can substantially reduce the global health burden of wildfire smoke, but innovative solutions are needed to overcome financial barriers.

Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04353-2 OBSCORE is a machine learning-based risk prediction tool that uses a set of clinical features to stratify individuals with a body mass index (BMI) of ≥ 27 kg m−2 by their 10-year risk of obesity-related complications, outperforming existing models. OBSCORE is generalizable across diverse populations, supporting risk-…

Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04370-1 To inform precision management of obesity, this study developed and externally validated a parsimonious model (OBSCORE) that accurately predicts the risk of 18 obesity-related complications. This was achieved by integrating thousands of clinical, molecular and other health-related characteristics assessed in 200,000 …

Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04369-8 The alarming rise in the incidence of colorectal cancer among younger individuals is probably due to environmental factors; epigenetic signatures of exposures may help uncover drivers of this trend, but questions remain.

Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04338-1 A multicountry cohort study found that prediction models combining clinical parameters with either pulse oximetry or the host biomarker sTREM1 more accurately identified febrile children needing referral than standard WHO criteria.

Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04366-x Preclinical and phase 1/2 trial data show that anti-CD38 monoclonal antibody treatment restores platelet counts in patients with immune thrombocytopenia by increasing nicotinamide adenine dinucleotide (NAD+) levels, and low-dose oral treatment with the NAD+ precursor nicotinamide mononucleotide can similarly increase…

Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04357-y Evaluated across 18 multicancer cohorts, the agentic artificial intelligence workflow SPARK uses language as a universal interface to autonomously generate biological ideas.

Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04359-w Reti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.

Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04267-z A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis

Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04372-z Genomic screening is increasing rapidly, but insurance protections globally are outdated. Australia’s new law offers the clearest model yet for safeguarding public trust while supporting population genomics.

Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04368-9 As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.

Nature Medicine, Published online: 27 April 2026; doi:10.1038/s41591-026-04333-6 Selective removal of the placental protein sFlt-1 via antibody-based apheresis was safe and was associated with modest reductions in blood pressure and prolongation of pregnancy in women with very preterm preeclampsia. The treatment supports conducting controlled trials to evaluate its safety and efficacy at a larger…