precision-medicine

From Biomarker Validation to Multi-Omics: Preparing Bioanalysis for the Next Generation of Precision Medicine By Ruwini Rajapaksha, PhD, Postdoctoral Fellow at Lovelace Biomedical Throughout my career, I have had the opportunity to work across academic research, startup innovation, diagnostics development, and preclinical bioanalysis. While the technologies and applications have varied— from opto…

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide and is characterized by substantial clinical, imaging, and molecular heterogeneity that complicates disease prediction and therapeutic management. Recent advances in artificial intelligence (AI) and precision therapeutics have created new opportunities for more individualized and data-driven AMD care. …

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

USC research shows that a common genetic variant in Indigenous American populations silences the mitochondrial microprotein “MENTSH.” Restoring it improves insulin signaling and blocks diet-induced weight gain in preclinical studies. The post Newly discovered microprotein linked to Type 2 diabetes, shows promise as a precision treatment appeared first on USC .

Emerging Trends in Precision Medicine: A Systematic Review of Clinical Applications No results See all results High-Impact Journals Understanding Precision Medicine Evolution of Precision Medicine in […] The post Emerging Trends in Precision Medicine: A Systematic Review of Clinical Applications appeared first on Pubrica .

Clinical biobanks that combine genomic data with electronic health records (EHRs) have become powerful resources for discovering genetic variants associated with disease.

One disease can look very different across individuals. Even within the same subtype of a particular disease, patients may experience dramatically different disease progression rates, treatment responses, complications, and more.

Why do some people lose substantial weight with GLP-1-based medications while others see more modest results? A Mayo Clinic study offers a potential answer by identifying a distinct biological subtype of obesity that responds especially well to tirzepatide, a medication that mimics two naturally occurring hormones involved in appetite and blood sugar regulation, moving the field closer to precisi…

BackgroundTuberculosis (TB) remains a global health crisis, with complex molecular mechanisms that are not fully understood. Traditional pathway analysis methods fail to capture the intricate non-linear relationships within biological networks.MethodsWe developed a novel artificial intelligence framework integrating graph neural networks (GNNs), transformer architectures, and multimodal deep lear…

Scientists at the Sbarro Health Research Organization (SHRO) have recently been named the recipients of The Joy Cappel Investigator Award in recognition of their work translating focused research into meaningful experimental tools and scientific advancement.

At ESHG 2026, MGI Tech presents cutting-edge genomics solutions, emphasizing automation and partnerships to enhance clinical workflows and precision medicine.

IntroductionPersonalized Medicine and precision therapeutics hold promise to revolutionize modern clinical practice, by improving clinical decision making and maximizing drug efficacy, while minimizing drug toxicity, based on the unique patient’s genetic profile. Clinical decision support tools aim to help clinicians to implement genome-guided therapeutics and genomic medicine with the translatio…

A UK Biobank study of nearly 390,000 people mapped 251 NMR-derived plasma metabolic traits against hundreds of health traits, prevalent diseases, and future disease outcomes. The atlas revealed tens of thousands of replicated associations, showed stronger prediction for selected short-term and cardiometabolic outcomes, and identified putative causal links that may guide future precision medicine …

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04421-7 The Hong Kong Genome Project established a genome sequencing database that provides improved diagnoses for patients and more efficient, population-tailored carrier status screening. Actionable pharmacogenomic variants were identified in almost all participants, informing drug prescriptions. This work establishes a gen…

Brain activity relating to how young adults value reward appears to be linked to longer-term drinking patterns, according to a study of college students with family histories of alcohol use disorder (AUD). The findings raise the possibility of precision medicine--individualized interventions to modify risk--for young people vulnerable to addiction.

Nature Communications, Published online: 19 May 2026; doi:10.1038/s41467-026-73212-y Precision oncology for hepatocellular carcinoma (HCC) remains challenging due to the high diversity of HCC at the clinical and molecular levels. Here, the authors employ an integrative multi-omics approach to identify and characterize nine molecular subtypes and explore their biological and clinical significance …

Nature Cell Biology, Published online: 13 May 2026; doi:10.1038/s41556-026-01957-1 Zhao et al. develop a microwell cell-chip-based culture platform that enables high-throughput generation of micro-tumourspheres and enrichment of functional cancer stem cells from biopsies obtained from patients with breast cancer, facilitating personalized drug testing.

Northeast Ohio Medical University (NEOMED) researchers are advancing precision medicine to replace one-size-fits-all prescribing with individualized drug therapies based on genetic differences. Led by Moses Oyewumi, Ph.D., NEOMED scientists are studying pharmacogenomics to better understand how patients absorb and respond to medications.