pulmonology

BackgroundChronic Obstructive Pulmonary Disease (COPD) is characterized by a progressive deterioration of lung function, which occurs at its fastest rate in the early stages (GOLD I-II). Preliminary clinical investigation has suggested that Cordyceps militaris capsules can improve post-bronchodilator forced expiratory volume in 1 s (FEV1) in mild-to-moderate COPD. However, previous studies were l…

Scientists have long known that smoking damages the lungs, but a new study has now shown in detail how smoking physically changes lung tissue itself. Researchers at University of California, Riverside have directly measured how smoking affects the mechanical behavior of human lungs. Their findings, published in the Journal of the Royal Society Interface, reveal […] The post Scientists directly me…

A new study has provided some of the clearest evidence yet of how smoking physically damages human lungs. For the first time, scientists directly measured how smoking changes the mechanical behavior of real human lung tissue and found that smoking makes the lungs significantly stiffer, similar to the damage seen in fibrosis, a serious lung […] The post Smoking makes human lungs stiffer like scar …

BackgroundChronic obstructive pulmonary disease (COPD) is a prevalent, debilitating condition linked to significant morbidity and mortality. While glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated clinical benefits for COPD, the effect of tirzepatide on COPD outcomes remains to be fully elucidated.MethodsThis study utilized the TriNetX Global Collaborative Network to analyze …

BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by airflow limitation and marked airway/systemic inflammation, particularly in elderly patients.ObjectiveTo evaluate the association between terbutaline sulfate plus ambroxol hydrochloride and clinical outcomes, pulmonary function, and inflammatory biomarkers in elderly patients with AECOPD.MethodsTh…

Qureight, an end-to-end imaging CRO that provides enterprise-grade imaging and precision endpoints for clinical trials with a focus on lung and heart disease, today announced it has established a Scientific Advisory Board (SAB) focused on pulmonary hypertension (PH).

BackgroundHyperoxia-induced acute lung injury (HALI) is a frequent and clinically relevant complication of oxygen therapy in critically ill patients. Excessive oxygen exposure induces severe oxidative stress and alveolar epithelial cell (AEC) injury, yet the upstream regulatory mechanisms governing regulated cell death under hyperoxic conditions remain incompletely understood. Ferroptosis, an iro…

ObjectiveGiven the high prevalence and clinical significance of insomnia in COPD patients, and the ongoing controversy surrounding benzodiazepine receptor positive allosteric modulators (PAMs) therapy, this study systematically evaluates the dual-temporal (short- and long-term) safety profile of PAMs through simultaneous assessment of therapeutic benefits and multidimensional risks in COPD-insomn…

A new study from researchers at National Jewish Health and collaborating institutions has found that different patterns seen on lung scans can signal how severe sarcoidosis may be, and how it affects breathing.

As people grow older, it is normal for the body to change in many ways. Muscles may become weaker, bones may lose strength, and the lungs may not work as well as they once did. However, new research suggests that obesity may add an extra burden on lung health in older adults, beyond what would […] The post Obesity decreases lung function in older people appeared first on Knowridge Science Report .

IntroductionAcute lung inflammation has recently gained increasing attention due to the high acute respiratory distress syndrome complications with subsequent fibrosis during the COVID-19 pandemic. Our group identified that the antifibrotic effect of the antidepressant fluvoxamine (FLU) in various organs is meditated via sigma-1 receptor (S1R) agonism. Since the actions of FLU on the inflammatory…

BackgroundsType 2 asthma is characterized by airway inflammation, mucus hypersecretion, and remodeling, and circadian rhythm dysregulation is implicated in its pathogenesis. Melatonin, a key circadian hormone, modulates inflammatory signaling, but its role in type 2 airway inflammation remains unclear. This study investigated whether melatonin alleviates airway inflammation and epithelial-mesench…

Next step Choose the next useful decision step first. Use the guide or checklist that matches this page's intent before you ask for a manuscript-level diagnostic. Quick answer: Pulmonology covers a wide range of conditions and research types: asthma, COPD, interstitial lung disease, pulmonary hypertension, lung cancer screening, respiratory infections, sleep medicine, and critical care. The journ…

Bronchoscopy in ventilated patients severely narrows the endotracheal tube lumen and increases resistance, which can lead to hypoventilation and intrinsic PEEP build-up. These ventilation impairments depend on the geometry of the tube-bronchoscope combination, ventilator settings, and patient mechanics. Currently, no predictive method exists to quantify these impairments or guide compensatory...

When it comes to keeping patients breathing comfortably, few specialties are as vital as pulmonology. Pulmonologists serve as the medical detectives of the respiratory system, diagnosing and treating conditions ranging from asthma to more complex illnesses such as lung cancer. Often on the frontlines in the ICU, when patients are struggling to breathe, their role is both challenging and deeply im…

A new Northwestern Medicine study is challenging long-held assumptions about chronic obstructive pulmonary disease (COPD), according to results published in The Journal of Clinical Investigation. The post Carbon Dioxide May Drive Lung Damage in COPD appeared first on News Center .

A new study led by Dr. Frank Sciurba, published in The New England Journal of Medicine, reveals that mepolizumab can significantly reduce exacerbations in COPD patients with eosinophilic inflammation—affecting up to 40% of those with the disease.

Better suppresses usual nocturnal worsening of asthma than dosing at other times May lead to better outcomes without increasing steroid-related side effects or costs A single daily preventer dose of inhaled corticosteroid (beclomethasone), taken mid afternoon, may be the best timing for effective asthma control as it suppresses the usual nocturnal worsening of symptoms more ...

Pulmonary & Respiratory Sciences - Juniper Publishers Abstract Idiopathic Pulmonary Fibrosis (IPF) presents a complex challenge in respiratory medicine, characterized by insidious onset and relentless progression. This comprehensive analysis delves into predictive biomarkers across diverse domains to enhance early detection, precise patient stratification, and personalized therapeutic interventio…