clinical-trials

Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-76662-6 With the improvement of HER2-targeted therapy in patients with breast cancer, there is growing interest in whether chemotherapy can be eliminated from regimens completely. Here, the authors report a phase 2 clinical trial investigating neoadjuvant zanidatamab (HER2-targeting antibody) in patients with early-st…

The Phase 3 study is evaluating two doses of Novo’s Wegovy pill in people with obesity or overweight in combination with a reduced-calorie diet and increased physical activity.

A comparative study of the cancer clinical trial portfolios supported by federal funding versus industry funding reveals they have distinct, interdependent roles in cancer research.

The Department of Health and Human Services has launched an effort to streamline clinical research, and legislation is pending in Congress. But patients and providers face participation challenges.

A randomized controlled trial has shown that Metaberine significantly enhances metabolic health factors at a low dosage. The berberine ingredient, by nutraceutical company Zeus Hygia Life Sciences, improved fasting glucose levels, GLP-1 secretion, and lipid profiles compared to placebo, at a five- to seven-fold lower dose than conventional formulations.

Scientific Reports, Published online: 16 August 2026; doi:10.1038/s41598-026-66393-5 A randomized crossover clinical study comparing free flow helmet CPAP with full face mask CPAP in acute hypoxemic respiratory failure

Scientific Reports, Published online: 14 August 2026; doi:10.1038/s41598-026-66951-x Postoperative pain after single-visit root canal treatment in teeth with periapical lesion using different irrigation activation techniques: a randomized clinical trial

Note: for a less-technical version, see: Clinical trials Clinical trials vary but the basic idea with most is that clinicians […]

Nature Medicine, Published online: 12 August 2026; doi:10.1038/s41591-026-04564-7 In a multicenter, phase 2 trial, patients with treatment-naive locally advanced unresectable or metastatic triple-negative breast cancer were treated with the PD-1/vascular endothelial growth factor bispecific antibody ivonescimab plus chemotherapy, resulting in encouraging preliminary objective response rates, whic…

The University of Chicago Medicine Comprehensive Cancer Center (UCCCC) and Eli Lilly and Company (Lilly) have partnered to help patients gain greater access to potential cancer treatments by participating in clinical trials. The two-year partnership creates a strong foundation for the two organizations to work together over time to expand access to clinical trials with innovative investigational …

The University of Chicago Medicine Comprehensive Cancer Center (UCCCC) and Eli Lilly and Company (Lilly) have partnered to help patients gain greater access to potential cancer treatments by participating in clinical trials. The two-year partnership creates a strong foundation for the two organizations to work together over time to expand access to clinical trials with innovative investigational …

Researchers found that dexamethasone eye drops may reduce the risk that retinopathy of prematurity advances to the treatment stage. For babies born extremely early, abnormal blood vessel growth in the retina can threaten their sight before they leave the hospital. Researchers in Sweden have now completed the world’s first randomized clinical trial testing whether cortisone [...]

Scientific Reports, Published online: 10 August 2026; doi:10.1038/s41598-026-64669-4 Phase II Non-Randomised Trial of Oral Chlorophyllin in Haemorrhagic Cystitis from Radiation Therapy (CLARITY Trial): clinical and quality-of-life outcomes with exploratory proteomics

IntroductionLow-dose computed tomography (CT) scans can induce DNA damage, including chromosomal aberrations (CAs) and DNA double-strand breaks, which may contribute to long-term cancer risk. D-limonene, a bioactive component present in several Kampo formulas, has shown radioprotective effects in preclinical studies; however, clinical evidence remains limited, and the gastrointestinal side effect…

Nature Medicine, Published online: 06 August 2026; doi:10.1038/s41591-026-04541-0 In a publicly funded trial undertaken in the NHS in England, 60 adults with treatment-resistant major depression received psilocybin or placebo alongside standardized psychological support, with psilocybin showing significant improvements in depression symptoms, good tolerability and support for further research in …

Nature Medicine, Published online: 06 August 2026; doi:10.1038/s41591-026-04557-6 In this phase 1 dose-escalation trial, intracranial delivery of B7-H3-targeting chimeric antigen receptor T cell therapy in patients with glioblastoma showed no dose-limiting toxicity signals and encouraging signals of clinical benefit.

Nature, Published online: 05 August 2026; doi:10.1038/d41586-026-02440-5 Existing treatments for food allergy are limited.

Altering the gut microbiomes of people with peanut allergy using faeces donated from an allergy-free individual improved their peanut tolerance in a clinical trial