clinical-trials

BackgroundBreast cancer patients are at an increased risk of insomnia, which can lead to emotional disorders, reduced quality of life, and potentially higher cancer mortality. Auricular acupuncture (AA) offers a feasible treatment option due to its short procedure time, low technical complexity, and relative safety. However, while preliminary studies suggest potential benefits of AA for treating …

Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-73562-7 While first-line immunochemotherapy has shown efficacy in patients with extensive-stage small-cell lung cancer (ES-SCLC), survival benefit is limited. Here, the authors report a phase II randomised clinical trial comparing durvalumab (anti-PD-1) plus anlotinib (multi-TKI) against durvalumab alone as maintenance t…

A surprisingly simple walking tweak may offer new hope for millions living with knee osteoarthritis. In a year-long clinical trial, researchers found that slightly changing the angle of a person’s foot while walking reduced knee pain as effectively as common medications — and even slowed cartilage damage inside the joint.

A small proof-of-concept RCT found that tocilizumab, an IL-6 receptor blocker, showed a non-significant but clinically suggestive pattern of improvement in difficult-to-treat depression linked to low-grade inflammation. The study found that baseline hs-CRP, rather than IL-6, may help identify patients most likely to respond, supporting larger trials of immune-targeted depression care.

I am pleased to share the findings of our randomized clinical trial, published in 2023, which demonstrated the beneficial effects of dual-strain probiotics on weight gain among premature neonates in Afghanistan. Encouragingly, subsequent meta-analyses have supported the findings of our study.

Researchers are now enrolling participants in a clinical trial using focused ultrasound to treat certain types of pancreatic cancer.

Clinical trials in Saudi Arabia are rapidly expanding, aimed at establishing the Kingdom as a regional hub for medical research by... The post How Saudi Arabia’s Brands Use Clinical Trials to Drive Evidence Generation Research appeared first on Food Research Lab .

The Akkermansia Company today announced the publication of a new randomized, placebo-controlled clinical trial in Nature Medicine demonstrating that supplementation with pasteurized Akkermansia muciniphila MucT(r), the proprietary bacterial strain used in the company's products, significantly improved weight loss maintenance in adults with overweight or obesity following an initial weight loss in…

As global clinical trials continue to expand in scale and complexity, operating models have evolved to emphasize centralized planning, standardized processes, and coordinated oversight. These approaches are essential for managing large, distributed programs and ensuring consistency across geographies. However, they do not fully account for where trial performance is ultimately determined.  In pra…

The takeaway: Orforglipron is an FDA-approved non-peptide oral GLP-1 pill, offering a potential alternative to injectable weight-loss drugs. Demand for GLP-1 medications has surged in recent years, but cost and injectable delivery have limited access for many patients. A CU Anschutz researcher is overseeing a clinical trial for orforglipron, and a patient shares her experience in the trial. Every…

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04402-w An open-label, randomized controlled phase 2 trial comparing favipiravir with ribavirin for the treatment of mild-to-moderate Lassa fever in Nigeria found that favipiravir was safe and well tolerated and supports its further optimization as a treatment alternative.

Increasing bone density in patients with a rare genetic condition that causes bones to break easily does not prevent fractures, a large clinical trial has found.

Nature Medicine, Published online: 14 May 2026; doi:10.1038/s41591-026-04395-6 Subcutaneous injections of abatacept were superior to oral hydroxychloroquine in preventing progression to persistent arthritis in individuals with palindromic rheumatism.

Nature Communications, Published online: 14 May 2026; doi:10.1038/s41467-026-72125-0 Epithelial ovarian cancer (EOC) frequently relapses with rising chemoresistance. This phase 1/2 trial evaluates MVP-S vaccination plus pembrolizumab and cyclophosphamide in recurrent EOC, assessing safety, clinical efficacy outcomes, and MVP-S-specific immunity.

Oral orforglipron helped adults maintain clinically meaningful weight loss after prior injectable tirzepatide or semaglutide therapy. The phase 3b ATTAIN-MAINTAIN trial suggests switching to once-daily oral therapy may help reduce weight regain when injectable treatment is discontinued.

Nature Reviews Drug Discovery, Published online: 13 May 2026; doi:10.1038/d41573-026-00081-x Trends in the landscape of clinical trials of innovative drugs in China since 2015

BackgroundCancer-Related Fatigue (CRF) is one of the most prominent subjective symptoms that cancer patients encounter, in particular individuals with gastrointestinal tumors. This fatigue significantly impacts their quality of life, impairs adherence to treatment, and may ultimately reduce overall survival rates. Moxibustion has gradually gained recognition as a therapeutic intervention for CRF.…

Nature Medicine, Published online: 10 May 2026; doi:10.1038/s41591-026-04408-4 As presented at the 2026 ESC Heart Failure Congress, in a phase 2 randomized trial in patients with heart failure with reduced left ventricular ejection fraction after myocardial infarction, treatment with CDR132L, an antisense oligonucleotide inhibitor of miR-132, was well tolerated but did not have a significant effe…

Nature Medicine, Published online: 10 May 2026; doi:10.1038/s41591-026-04406-6 As presented at the 2026 ESC Heart Failure Congress, in a large randomized controlled trial in patients with heart failure with reduced or mildly reduced ejection fraction, treatment with low-dose digoxin was generally safe and well tolerated, but did not significantly reduce the composite endpoint of total worsening h…