clinical-trials

The Alliance for Clinical Trials in Oncology is now enrolling patients in the ASPIRE trial (A032302)-a large-scale, phase III clinical study investigating whether adding chemotherapy to current standard treatments extends survival for men with advanced prostate cancer.

A randomized controlled trial compared the efficacy, tolerability, and safety of different volumes of polyethylene glycol (PEG) regimens for bowel preparation for inpatient colonoscopy.

Researchers are using focused ultrasound to develop innovative treatments for serious and cancerous conditions of the brain, heart, bones, and more.

The first participants have been enrolled in a pivotal clinical trial for the treatment of chronic pain.

Charlottesville, VA, and Chicago, IL — April 28, 2026 — The Focused Ultrasound Foundation and CURE Epilepsy have announced the co-funding of an innovative CURE Epilepsy Catalyst Award research grant that may pave the way for better control of debilitating seizures in children. The project aims to develop a noninvasive treatment for a severe form ...

ObjectiveTo systematically evaluate the impact of pharmacist interventions on the implementation and clinical efficacy of vancomycin therapeutic drug monitoring (TDM).MethodsA Cochrane systematic review methodology was employed. Databases including PubMed, Medline, Embase, Cochrane Library, CNKI, and Sinomed were searched. After quality assessment and data extraction of eligible clinical studies,…

IntroductionThis clinical trial aimed to assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of LW402, a preferential JAK1 inhibitor, in healthy participants, so as to provide support for its further development in treating autoimmune diseases.MethodsThe study included two phases: a single ascending dose (10–400 mg) with 54 participants and a multiple ascending dose (50–150 mg, b.…

A new approach to treating certain bowel cancers is showing long-lasting effects. Patients with a particular form of bowel cancer have remained cancer-free for nearly three years after receiving a short course of immunotherapy before surgery, rather than chemotherapy afterward. These findings come from the NEOPRISM-CRC clinical trial led by researchers at UCL and UCLH. [...]

Jurassic Park actor is advocating for CAR T-cell therapy, which he underwent as part of a clinical trial, to be rolled out for blood cancer patients across Australia Sam Neill has announced he is now cancer-free after undergoing a new treatment when chemotherapy stopped working on his stage-three blood cancer. The Jurassic Park actor made the announcement on Australian broadcaster 7News while adv…

A five-year, multisite clinical trial will compare two medication strategies for advanced chronic kidney disease, enrolling 1,350 participants nationwide. Advanced chronic kidney disease (CKD) affects over 1 million people in the US. Individuals with advanced CKD have high risks of kidney failure requiring dialysis or transplantation, cardiovascular events, hospitalizations, and death, as well as…

A procedure designed to reopen blocked veins successfully reduced pain, swelling and disability in people with post-thrombotic syndrome — a common and often debilitating complication of deep vein thrombosis — according to results of a clinical trial published in The New England Journal of Medicine. The post Stents Can Ease Symptoms of Post-Thrombotic Syndrome appeared first on News Center .

IntroductionVenous leg ulcers (VLUs) represent a major chronic wound condition associated with high recurrence rates, prolonged healing, and substantial socioeconomic burden. Hydrogels have recently gained attention as effective wound dressings due to their moisture-retentive and biocompatible properties. This study aimed to evaluate the clinical effectiveness of a combined therapy using octenidi…

Nature Medicine, Published online: 27 April 2026; doi:10.1038/s41591-026-04333-6 Selective removal of the placental protein sFlt-1 via antibody-based apheresis was safe and was associated with modest reductions in blood pressure and prolongation of pregnancy in women with very preterm preeclampsia. The treatment supports conducting controlled trials to evaluate its safety and efficacy at a larger…

ObjectiveTo explore the preliminary clinical efficacy and safety of acupuncture plus wet cupping on post-stroke depression (PSD) and to investigate its potential associations with changes in the hypothalamic-pituitary-adrenal (HPA) axis and inflammatory factors.Methods130 mild-to-moderate PSD patients were randomized into two groups: an acupuncture plus wet cupping therapy group (AC group, n=65) …

​Results of the single-center, phase 2 CAR-PRISM (PRecision Intervention Smoldering Myeloma) clinical trial, the first to investigate Chimeric Antigen Receptor (CAR) T-cell therapy in patients with high-risk smoldering multiple myeloma, showed that all 20 patients were negative for minimal residual disease (MRD) within two months of treatment and remained MRD-negative after a median of 15.3 month…

REVA Medical, LLC today announced primary endpoint results from the MOTIV BTK randomized pivotal clinical trial evaluating the MOTIV(r) sirolimus-eluting bioresorbable vascular scaffold in patients with critical limb-threatening ischemia (CLTI).

Introduction   Clinical trial activity is one of the clearest indicators of where the biopharma industry is directing its clinical development efforts. An analysis of ongoing and completed clinical trial activity across companies headquartered in North America and Europe reveals important shifts in therapeutic area focus, development phase distribution, and emerging innovation areas such as rare …

IntroductionErectile dysfunction (ED) is often treated with phosphodiesterase type 5 inhibitors (PDE5i). However, some patients do not respond effectively to this treatment, making regenerative therapy a potential alternative. This study aims to evaluate the safety and efficacy of umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome in patients with severe ED who are unresponsive to si…

Scientific Reports, Published online: 21 April 2026; doi:10.1038/s41598-026-46571-1 Premixed nitrous oxide/oxygen analgesia for removal of vacuum assisted closure dressing: a randomized, double-blinded placebo-controlled trial

A diner scans the menu with her eyes while strands of conversation and random noise – from her party, from other customers, from the kitchen – bombard her ears. She leans in but deciphering what’s being said just across the table can be challenging, if not impossible.