Newswise Feature Channel: Clinical Trials

A first-in-class therapy to target MYC, one of the most sought-after and difficult targets in cancer biology, showed promise in hard-to-treat blood cancers, according to a new preclinical study from The University of Texas MD Anderson Cancer Center published in Blood.

Researchers at UT Southwestern Medical Center studying Parkinson's disease have discovered a previously unrecognized sequence of abnormal activity across multiple regions of the brain, providing a new level of understanding that could improve treatment options.

Dr. Mina Sedrak is developing strategies to improve physical recovery and reduce frailty in older adults following hematopoietic cell transplantation, commonly known as a bone marrow or stem cell transplant.

Researchers at Washington University in St. Louis have developed a technique that researchers and clinicians can use to assess the reliability of medical imaging tools. The new method also may be useful for regulators who evaluate new AI-backed medical imaging tools as they come to market.

University of Michigan researchers identified two pathways that can simultaneously be targeted to treat transdifferentiated prostate tumors. They hope that their findings can also be applied to other transdifferentiated cancers, including those in the lungs and pancreas.

Spinach, almonds, and sweet potatoes are celebrated as some of the healthiest foods on the planet. But for the millions of Americans living with inflammatory bowel disease (IBD), a new study from the UNC School of Medicine suggests that these same foods may be quietly worsening gut inflammation through a compound most people have never heard of.

Australian researchers have identified a molecular switch that drives the spread of the most aggressive sub-type of breast cancer (triple-negative breast cancer), potentially paving the way for more effective treatments.

A long-standing rule in stem cell transplantation is being challenged. New ACCESS trial findings in Blood Advances show encouraging outcomes with younger, more genetically mismatched unrelated donors. Lead author Antonio Jimenez Jimenez, M.D., can discuss how the findings are reshaping donor selection and patient care.

A large international study of more than 14,000 patients with non-small cell lung cancer found that younger adults were significantly more likely than older patients to have genetic alterations that can be targeted with existing therapies.

Senescence is a state in which stressed cells stop dividing but remain alive. New findings reveal that the underlying process unfolds in distinct stages that depend on the type of drug used, and show how a new class of drugs triggers inflammation.

Researchers at the Icahn School of Medicine at Mount Sinai found that a chemotherapy-free combination of four targeted therapies showed encouraging results in patients with HR-positive, HER2-positive metastatic breast cancer, offering a potential first-line treatment option that may be more convenient for some patients and avoids chemotherapy.

Jordyn Bugarin had made up her mind. After a brutal experience with an experimental drug at another institution -- one that left her skin peeling and her mental health in free fall -- the 22-year-old was finished with clinical research. R..

A pilot study co-led by IU found that a daily 20 mg dose of zinc reduced infections by 38% in young Ugandan children with sickle cell anemia. The researchers believe this affordable solution can be rapidly deployed to save children's lives worldwide.

Galvanize Therapeutics, Inc., a commercial-stage medical technology company pioneering pulsed electric field (PEF) therapies for oncology and chronic lung disease, today announced two new peer-reviewed publications that add to the growing body evidence suggesting Aliya PEF may do more than ablate tissue locally - it may also be immune system activating.

In a new study, scientists from Johns Hopkins Medicine report that an experimental mRNA-based platform has the potential to help deliver next-generation mRNA therapeutics, including vaccines fighting against infectious disease, cancer and autoimmune conditions, faster and more efficiently than the industry standard.

Mayo Clinic researchers have estimated the risk that pancreatic cysts with worrisome or high-risk features will progress to pancreatic cancer or advanced precancerous changes within three years. The findings, published in Gastroenterology, could help physicians and patients better assess risk and make more informed decisions about whether to monitor a cyst or consider surgery.

While a treatment that regrows lost limbs in humans remains many years away, the research of Wake Forest University's Josh Currie has brought the goal one step closer.

A new generation of blood tests may change how Alzheimer's disease is diagnosed. A neurologist answers common questions about these tests.

Medical imaging foundation models are reshaping how artificial intelligence (AI) may interpret scans, combine clinical information, and support multiple tasks from a shared computational base. Rather than training a separate model for every disease or imaging problem, the approach uses large-scale pre-training to encode reusable knowledge into generalizable representations, which can then be adap…

Researchers at The University of Texas MD Anderson Cancer Center found that, in preclinical models of colorectal cancer, tumors can start damaging peripheral nerves before chemotherapy begins.