anesthesiology

A new study suggests anesthesiologists may be able to safely increase the likelihood that patients dream during surgery -- and that those dreams are typically positive, calming and associated with a better overall surgical experience.

BackgroundPostoperative sleep disturbance (PSD) is a common complication after general anesthesia and is associated with delayed recovery and other adverse postoperative outcomes. Perioperative esketamine may improve postoperative sleep, but current evidence remains inconclusive. This systematic review and meta-analysis assessed the efficacy and safety of perioperative esketamine for preventing P…

Perioperative anaphylaxis is a rare, life‑threatening condition during anesthesia. The unique setting – multiple drugs, patient draping, and altered physiology – causes higher mortality than anaphylaxis elsewhere.

ObjectiveThe research is to explore the half effective dose (ED50) and 95% effective dose (ED95) of ciprofol with intraperitoneal injection of 8-week-old C57BL/6J adult mice, which will provide experimental basis for the reasonable dose design of ciprofol in preclinical basic research.MethodsC57BL/6J mice were selected and divided into 8 dose groups (50, 55, 60, 65, 70, 80, 90, 100 mg/kg), with 1…

BackgroundThe elderly population experiences diminished physiological function and reduced tolerance to surgery and anesthesia. This study explored the role of the esketamine-based multimodal low-opioid anaesthesia during the perioperative period in improving the quality of postoperative recovery in elderly patients undergoing thoracoscopic radical lung cancer resection.Materials and methodsThis …

(Newsweek) – Doctors decided to place her in a medically induced coma. But while the paralytic drugs worked, Millie said the sedative did not fully take effect, leaving her aware of what was happening around her despite being unable to … Read More

BackgroundEtomidate is commonly used for sedation during gastroscopy but is associated with a high incidence of myoclonus. This study evaluated the effectiveness of oliceridine pretreatment in reducing etomidate-induced myoclonus.MethodsIn this prospective, double-blind, randomized controlled trial, 150 patients undergoing painless gastroscopy were assigned to receive oliceridine at 0.01 mg/kg (G…

Nature Communications, Published online: 04 May 2026; doi:10.1038/s41467-026-72614-2 The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

IntroductionPropofol-based sedation for gastroscopy is effective but may cause dose-dependent cardiorespiratory depression; therefore, optimizing adjunct strategies to reduce propofol exposure is clinically important.MethodsWe conducted a prospective, single-center, randomized, double-blind, dose-response trial to evaluate the propofol-sparing effect of remimazolam during procedural sedation for …

IntroductionDespite the established use of nalbuphine hydrochloride in anesthesia and obstetrics, high-quality evidence supporting its application in the intensive care unit (ICU) remains limited. This study aims to assess the efficacy and safety of nalbuphine hydrochloride for analgesia in ICU patients.MethodsThis is a multicenter, randomized, single-blind, parallel, positive control study. Elig…

BackgroundCombination sedation regimens are widely used in pediatric procedural sedation. However, the efficacy and incidence of post-discharge adverse events between intranasal dexmedetomidine combined with oral chloral hydrate and intranasal dexmedetomidine combined with oral midazolam remain unclear.MethodsThis was a single-center, prospective, randomized controlled trial. A total of 180 child…

Background and ObjectivesAdequate sedation with preserved spontaneous breathing and stable hemodynamics is critical for the success and safety of fiberoptic bronchoscopy (FOB). Remimazolam, a novel ultra-short-acting benzodiazepine with rapid metabolism and favorable sedative profiles, has shown promising sedative effects for procedural sedation. However, comparative data on its application in FO…

BackgroundPostpartum depression (PPD) is a significant concern in obstetrics. This study aimed to investigate the effects of hydromorphone in patient-controlled intravenous analgesia (PCIA) on PPD and sleep disorders following cesarean section.MethodsA total of 140 parturients undergoing elective cesarean section under combined spinal-epidural anesthesia, with singleton full-term pregnancy and ag…

BackgroundPostoperative nausea and vomiting (PONV) continue to be some of the most common and troublesome complications following anesthesia. Oliceridine, a G protein-biased µ-opioid receptor agonist, has the potential to provide effective pain relief while reducing the incidence of opioid-associated side effects.ObjectivesThe aim of this study is to evaluate the effectiveness and safety of olice…

Scientific Reports, Published online: 21 April 2026; doi:10.1038/s41598-026-46571-1 Premixed nitrous oxide/oxygen analgesia for removal of vacuum assisted closure dressing: a randomized, double-blinded placebo-controlled trial

Cannabis use has become more common in many parts of the world, especially in places where it is legal for medical or recreational use. Many people see it as a natural and relatively safe substance. However, a new study from Colorado shows that regular cannabis use may have unexpected effects during medical procedures. Researchers found […] The post Cannabis users may need 200% more sedation duri…

Below you will find 10 of the best med school admissions coaches with anesthesiology backgrounds in the USA. Please note that this is a curated list of top experts and not a ‘ranking’ of them. Below you will find 10 of the best med school admissions coaches with anesthesiology backgrounds in the USA. Please note that this is a curated list of top experts and not a ‘ranking’ of them. Dr. Chokkara …

Findings highlight need to reassess intraoperative pain relief strategies, say researchers The use of powerful synthetic opioids, such as sufentanil and remifentanil, during surgery is linked to a subsequent poor ‘pain experience’---a composite of emotional, cognitive, and physical aspects of pain— suggests research published in the open access journal Regional Anesthesia & Pain Medicine. The fin…

Novel anesthesia-inducing drugs developed through multidisciplinary neuroscience-driven approaches could help save numerous lives in conflict and disaster situations