pain-management

ObjectiveTo evaluate the effects of various transcranial magnetic stimulation (TMS) parameters—including stimulation duration, intensity, pulse number, frequency, and target region—on pain scores in patients with neuropathic pain (NP).MethodsRandomized controlled trials (RCTs) assessing the effects of TMS on NP were identified through searches of PubMed, Embase, Web of Science, and the Cochrane L…

A sweeping analysis of nearly 10,000 patients challenges assumptions about how best to treat knee osteoarthritis. For many people with knee osteoarthritis, relief may not require medication. A large new analysis suggests that simple physical treatments can ease pain and improve movement, often more effectively than some high-tech options. Knee osteoarthritis is one of the [...]

BackgroundClinical trials of brief mindfulness interventions (BMIs) for chronic pain frequently report small average effect sizes, which may mask substantial heterogeneity in treatment responses. Rather than testing general efficacy, this exploratory study investigated whether a BMI is associated with concurrently coupled psychological and sensory improvements within individuals, potentially refl…

ObjectiveThe purpose of this study was to evaluate the efficacy and safety of Nalbuphine compared to Pethidine for pain relief during oocyte retrieval.MethodsIn a double-blinded, non-inferiority randomized controlled trial (n = 94), participants were randomized equally into two groups. The intervention group received 10 mg intravenous Nalbuphine combined with 5 mg of Midazolam, while the control …

The first participants have been enrolled in a pivotal clinical trial for the treatment of chronic pain.

Chronic pain is a condition that affects millions of people around the world. Unlike short-term pain that goes away after an injury heals, chronic pain lasts for months or even years. It can affect how people work, move, sleep, and enjoy life. Many people focus on the physical causes of pain, but scientists are now […] The post Why struggling to understand your feelings can make chronic pain wors…

A large, two-year study led by researchers at Johns Hopkins Medicine and consisting of more than 1,400 adults living with chronic pain across the United States found that people who struggle to identify and describe their emotions experience greater disruption to daily life from pain over time due to increased psychological distress.

Living with chronic knee pain can make everyday life difficult. Simple tasks like walking, climbing stairs, or even standing for long periods can become uncomfortable. Because of this, many people look for different treatments to ease their pain. Some have turned to combining cannabis with opioid medications, hoping the two together might provide better relief. […] The post Cannabis may not boost…

Chronic low back pain is a condition that affects millions of people and can make everyday life difficult. It can limit movement, reduce the ability to work, and cause ongoing discomfort. Because it often lasts for a long time and does not always have a clear cause, finding the best treatment can be challenging. A […] The post Which popular treatment is best for long-term back pain? appeared firs…

A new study, led by researchers from the University of Tokyo, involving nearly 1,000 patients in Japan suggests that attention deficit hyperactivity disorder (ADHD)-related traits may be associated with and may contribute to chronic pain.

Temporomandibular joint disorders (TMDs) affect a large portion of the global population and are a common source of chronic jaw pain and difficulty in chewing or speaking.

Many people who live with ongoing pain are constantly searching for better ways to feel relief. Knee arthritis, also known as knee osteoarthritis, is one of the most common causes of pain, especially in older adults. It happens when the cartilage in the knee joint wears down over time, leading to stiffness, swelling, and pain […] The post Mixing cannabis and opioids may not ease arthritis pain ap…

A new study has explored an important question faced by many people living with long-term back pain: what type of treatment should you try first? Chronic low back pain is one of the most common health problems worldwide. It affects daily life, work, and mental health. Many people struggle to find relief, and doctors often […] The post Which treatment works best first for chronic back pain? appear…

Overlooked plant compounds may quietly hold new clues for treating some of the most challenging forms of pain. Researchers at the University of Arizona Health Sciences say compounds from Cannabis sativa may help ease two difficult types of pain: fibromyalgia and pain after surgery. Their findings, published in Pharmacological Reports, suggest that terpenes could offer [...]

Nature Communications, Published online: 21 April 2026; doi:10.1038/s41467-026-72214-0 The neuroanatomical basis of auricular vagus nerve stimulation-induced analgesia remains unclear. Here, the authors identify an auricle-to-brain axis from the auricular concha to the ventrolateral periaqueductal gray, which engages the descending antinociceptive pathway.

A sequential, multiple assignment, randomized trial (SMART) found that people with chronic low back pain experienced slight improvement in daily function when starting treatment with physical therapy compared with cognitive behavioral therapy.

Chronic nerve pain is a difficult condition that affects millions of people around the world. In the United States alone, more than 20 million people live with a type of nerve pain known as neuropathic pain. This kind of pain happens when the nerves themselves are damaged or not working properly. Unlike pain from an […] The post These two drugs could help treat unexplained nerve pain, study finds…

IntroductionKnee osteoarthritis (KOA) is a degenerative bone and joint disease. Jingu Zhitong Gel (JGZTG) exhibits a promising therapeutic effect in the clinical treatment of knee osteoarthritis (KOA). However, the mechanism of JGZTG in treating KOA remains unclear.MethodsWe established a rat model of KOA through surgery and treated rats with JGZTG for 21 days. The pain threshold was measured by …

Whether you have a medical condition or you want to be comfortable while sitting for long periods, these cushion seats have your behind As a writer and frequent traveler, I often find myself sitting for very long periods of time. Normally, that’s not something to worry about too much, but just over a year ago, I was diagnosed with spinal stenosis, which is a fancy way of saying my back hurts if I…

Repeated menstrual cycles may do more than trigger endometriosis. They may rewire the brain.