pain-management

Purpose of Review Intervention trials for cervicogenic headache (CGH) often yield equivocal results with marked treatment effect heterogeneity, possibly reflecting variations in underlying pain mechanisms throughout the CGH population. Pain phenotyping or classifying patients into subgroups based on their predominant pain mechanism may facilitate more precise CGH treatment. This review aims to ex…

A drug strategy abandoned after causing tremors, seizures and death in animals has been revived with a redesign that makes the compound less “sticky” — allowing it to let go faster from its target in the spinal cord. In mice, the new version relieved neuropathic pain without the dangerous side effects that derailed earlier attempts, potentially opening a new path beyond opioids for chronic nerve …

A drug strategy abandoned after causing tremors, seizures and death in animals has been revived with a redesign that makes the compound less “sticky” — allowing it to let go faster from its target in the spinal cord. In mice, the new version relieved neuropathic pain without the dangerous side effects that derailed earlier attempts, potentially opening a new path beyond opioids for chronic nerve …

For millions of people living with osteoarthritis, daily life can involve a frustrating cycle of pain and stiffness. While current treatments like over-the-counter medications or steroid injections can temporarily dull the ache, they do not stop the joint from deteriorating.

Scientific Reports, Published online: 09 June 2026; doi:10.1038/s41598-026-56099-z Correction: Effects of DRG pulsed radiofrequency parameters on the clinical outcome for battered sensory never syndrome: a prospective, triple-blind, randomized controlled trial

BackgroundLiposomal bupivacaine (LB) provides prolonged postoperative analgesia. This study aimed to evaluate the analgesic efficacy of erector spinae plane block (ESPB) using LB in patients undergoing spinal surgery.MethodsA total of 64 patients undergoing elective spinal surgery were randomly assigned in a 1:1 ratio to receive ESPB with 0.44% liposomal bupivacaine (LB group) or 0.4% ropivacaine…

A new study suggests that lingering rheumatoid arthritis symptoms are not always caused by ongoing inflammation. For people with rheumatoid arthritis, lingering pain and fatigue are often assumed to be signs that inflammation remains active. But new research suggests the real culprit may sometimes lie elsewhere. Researchers at Semmelweis University report that sleep disorders, depression, [...]

Back pain is one of the most common health problems in the world. Nearly everyone experiences it at some point in life. For some people, back pain appears after lifting a heavy object, bending awkwardly, or spending too much time sitting. In many cases, the pain improves within a few days or weeks. However, for […] The post New Injection Treatment May Help Ease Chronic Back Pain appeared first on…

For people living with osteoarthritis, everyday activities such as walking, climbing stairs, or getting out of a chair can become increasingly difficult. The disease affects hundreds of millions of people worldwide and is one of the leading causes of disability among older adults. Although doctors have many ways to manage pain, there is still no […] The post Existing Drug May Repair Joint Damage …

Scientific Reports, Published online: 30 May 2026; doi:10.1038/s41598-026-52127-0 Comparing the effects of ischemic compression and kinesiology taping techniques in patients with chronic low back pain

‘Tennis became a race against time’ after 2005 diagnosis ‘The suffering was less than my passion,’ says tennis great Rafael Nadal has revealed he spent most of his career in pain as he willed himself to play through a chronic foot injury and went on to win 22 grand slam titles while spending two decades ruling men’s tennis alongside Roger Federer and Novak Djokovic. The Spaniard, who retired in 2…

Researchers in the United Kingdom have discovered that psilocybin, the psychedelic compound found in magic mushrooms, may provide long-lasting relief from chronic nerve pain and may even help standard pain medications work better. The study, published in Communications Biology, suggests that psilocybin could eventually become part of a completely new approach to treating difficult chronic […] The…

Researchers at Duke University School of Medicine may have uncovered a surprising new strategy for treating chronic nerve pain: repairing the tiny energy factories inside damaged nerve cells. The study, published in Nature, found that restoring healthy mitochondria helped injured nerves recover and significantly reduced pain in laboratory models of diabetic nerve damage and chemotherapy-related […

A pilot randomized controlled trial found that vaginal bromocriptine reduced menstrual bleeding, pelvic pain, menstrual duration, and cycle irregularity in women with adenomyosis compared with routine treatment.

If you reach for ibuprofen or acetaminophen every time a headache hits, you're not alone. But if those headaches keep coming back, and seem to be getting more frequent, your medication might be part of the problem. This is called a rebound headache, and it's more common than most people realize. The post Rebound Headaches: What They Are and How to Treat Them appeared first on Neuroscience Group .

Millions of people around the world live with chronic nerve pain, a condition that can make even simple everyday sensations feel painful. For some people, a light touch, warm water, or gentle movement can trigger burning, tingling, or stabbing pain that lasts for months or even years. Doctors have long struggled to find effective treatments […] The post Scientists Discover New Way to Reduce Chron…

Scientists at the University of Reading have discovered that psilocybin, the active compound found in magic mushrooms, may provide long-lasting relief from nerve pain and may also improve the effectiveness of existing pain medications. The findings were published in the journal Communications Biology. Nerve pain, also known as neuropathic pain, is one of the most […] The post Single Dose of Psilo…

A daily inulin supplement may help reduce knee osteoarthritis pain while revealing a possible link between gut health, muscle function, and pain sensitivity. For millions of people living with knee osteoarthritis, managing chronic pain often means choosing between medications with unwanted side effects and exercise programs that can be difficult to maintain. Now, researchers have [...]

A single dose of psilocybin - the active compound in magic mushrooms - reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, University of Reading research has found.