pain-management

Scientists at the University of Reading have discovered that psilocybin, the active compound found in magic mushrooms, may provide long-lasting relief from nerve pain and may also improve the effectiveness of existing pain medications. The findings were published in the journal Communications Biology. Nerve pain, also known as neuropathic pain, is one of the most […] The post Single Dose of Psilo…

A daily inulin supplement may help reduce knee osteoarthritis pain while revealing a possible link between gut health, muscle function, and pain sensitivity. For millions of people living with knee osteoarthritis, managing chronic pain often means choosing between medications with unwanted side effects and exercise programs that can be difficult to maintain. Now, researchers have [...]

A single dose of psilocybin - the active compound in magic mushrooms - reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, University of Reading research has found.

Chronic pain is widely recognized as a major global health problem that affects approximately one-fifth of the adult population and is associated with significant physical, psychological, and socioeconomic burden. Current clinical analgesic strategies are mainly based on non-steroidal anti-inflammatory drugs, opioids, and adjuvant agents including antidepressants and antiepileptic drugs. However,…

A surprisingly simple walking tweak may offer new hope for millions living with knee osteoarthritis. In a year-long clinical trial, researchers found that slightly changing the angle of a person’s foot while walking reduced knee pain as effectively as common medications — and even slowed cartilage damage inside the joint.

A new medical study has found that breast cancer patients with low vitamin D levels may experience more pain after surgery and require larger amounts of opioid painkillers during recovery. The research, published in the journal Regional Anesthesia & Pain Medicine, suggests that checking vitamin D levels before surgery could potentially help improve patient care […] The post Breast cancer patients…

Vitamin D deficiency is associated with more moderate to severe pain following breast cancer surgery and an increased consumption of opioid drugs, finds research published online in the journal Regional Anesthesia & Pain Medicine.

Researchers at Rutgers University-New Brunswick are working to measure pain more accurately beyond the single, subjective question patients are often asked: "On a scale of 1 to 10, how bad is your pain?"

IntroductionLumbar disc herniation is commonly treated with epidural steroid injections to relieve radicular pain. Dexamethasone palmitate, a newer lipophilic formulation, is theoretically safer and provides longer-lasting effects compared to traditional corticosteroids like betamethasone. However, direct clinical evidence comparing their efficacy and safety is still limited.MethodsThis multicent…

For the 32 million Americans living with osteoarthritis, treatment options have included painkillers, injections or surgery. Now, UC San Diego Health is offering a new option -- low-dose radiation therapy (LDRT) for chronic joint pain.

BackgroundChronic low back pain (CLBP) is a common clinical syndrome and a leading cause of disability. The high disability rate associated with CLBP is more susceptible to reduced labor capacity, poorer quality of life, and increased psychological, social, and medical burdens. Tai Chi is an effective and safe therapy for treating chronic low back pain (CLBP).ObjectiveThis study aims to determine…

Chronic neuropathic pain remains one of the most challenging conditions to treat, with current therapies offering limited benefit and being over-reliant on opioids. Researchers at Rensselaer Polytechnic Institute (RPI), along with collaborators from the University of Sydney and the University of Copenhagen, have developed an approach that offers a clearer path towards safer, non-addictive pain th…

ObjectiveTo evaluate the effects of various transcranial magnetic stimulation (TMS) parameters—including stimulation duration, intensity, pulse number, frequency, and target region—on pain scores in patients with neuropathic pain (NP).MethodsRandomized controlled trials (RCTs) assessing the effects of TMS on NP were identified through searches of PubMed, Embase, Web of Science, and the Cochrane L…

A sweeping analysis of nearly 10,000 patients challenges assumptions about how best to treat knee osteoarthritis. For many people with knee osteoarthritis, relief may not require medication. A large new analysis suggests that simple physical treatments can ease pain and improve movement, often more effectively than some high-tech options. Knee osteoarthritis is one of the [...]

BackgroundClinical trials of brief mindfulness interventions (BMIs) for chronic pain frequently report small average effect sizes, which may mask substantial heterogeneity in treatment responses. Rather than testing general efficacy, this exploratory study investigated whether a BMI is associated with concurrently coupled psychological and sensory improvements within individuals, potentially refl…

ObjectiveThe purpose of this study was to evaluate the efficacy and safety of Nalbuphine compared to Pethidine for pain relief during oocyte retrieval.MethodsIn a double-blinded, non-inferiority randomized controlled trial (n = 94), participants were randomized equally into two groups. The intervention group received 10 mg intravenous Nalbuphine combined with 5 mg of Midazolam, while the control …

The first participants have been enrolled in a pivotal clinical trial for the treatment of chronic pain.

Chronic pain is a condition that affects millions of people around the world. Unlike short-term pain that goes away after an injury heals, chronic pain lasts for months or even years. It can affect how people work, move, sleep, and enjoy life. Many people focus on the physical causes of pain, but scientists are now […] The post Why struggling to understand your feelings can make chronic pain wors…

A large, two-year study led by researchers at Johns Hopkins Medicine and consisting of more than 1,400 adults living with chronic pain across the United States found that people who struggle to identify and describe their emotions experience greater disruption to daily life from pain over time due to increased psychological distress.

Living with chronic knee pain can make everyday life difficult. Simple tasks like walking, climbing stairs, or even standing for long periods can become uncomfortable. Because of this, many people look for different treatments to ease their pain. Some have turned to combining cannabis with opioid medications, hoping the two together might provide better relief. […] The post Cannabis may not boost…