obesity

New NIH research reveals that semaglutide sparks different responses inside appetite-controlling brain cells, offering fresh insight into why GLP-1 weight-loss drugs don’t work the same for everyone. Scientists also found a possible way to extend the drugs’ effects, potentially helping patients push past weight-loss plateaus.

A new “Trojan horse” weight-loss drug sneaks extra metabolic power into cells and delivers striking results in mice. Researchers at Helmholtz Munich have developed a new drug strategy that could improve treatment for obesity and type 2 diabetes. Led by metabolism scientist Prof Timo D. Müller, the team created a hybrid molecule that uses the [...]

Clinical obesity is reconceptualized in this manuscript as a structural affective–endocrine disorder emerging from a chronic fusion of two Core Emotion Framework (CEF) operators: Expanding and Accepting. This maladaptive “Expand–Accept” fusion produces a passive coping metabolic phenotype characterized by boundaryless somatic openness and involuntary yielding, described in the text as “a boundles…

Popular weight loss medications such as Ozempic, Wegovy, Saxenda, and Mounjaro have changed the way doctors treat obesity and type 2 diabetes. Millions of people around the world are now using these medications to help reduce appetite, lose weight, and improve blood sugar control. Now, a large new study presented at the European Congress on […] The post People Who Lost the Most Weight on Glp-1 Dr…

Nature Reviews Drug Discovery, Published online: 22 May 2026; doi:10.1038/d41573-026-00087-5 Incretin-based multi-agonist reverses obesity and diabetes

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04416-4 At week 68, in patients who experienced poor weight loss following bariatric surgery, semaglutide was associated with 18.0% weight loss compared to 0.4% weight gain in patients receiving placebo.

New research presented at the European Congress on Obesity (ECO 2026) suggests that people who lose more weight while taking popular GLP-1 medications may significantly lower their risk of several serious health conditions linked to obesity. The study also found that people who gained weight after starting these medications often had worse health outcomes. The […] The post Study finds bigger weig…

New research suggests obesity may leave a long-lasting “memory” on the immune system, even years after weight loss. Researchers have found that obesity may leave a lasting biological “memory” in the immune system, potentially increasing the risk of obesity-related diseases years after a person loses weight. The findings come from a decade-long study published in [...]

Researchers have discovered that certain patients with obstructive sleep apnea and obesity may experience much greater benefits from the GLP-1 medication tirzepatide than others. The findings could help doctors better predict who is most likely to improve with treatment and who may still need additional therapies for sleep apnea. The research was presented at the […] The post Why some people with…

A new study has found that some people with obstructive sleep apnea and obesity may benefit much more from the GLP-1 medication tirzepatide than others. Researchers say the findings could help doctors better predict which patients are likely to see the strongest improvements in their sleep apnea symptoms and who may still need additional treatments. […] The post Who can benefit most from popular …

Pennington Biomedical Research Center, in collaboration with Vanderbilt University Medical Center, has launched a research study, the COACH trial, to test different ways to help children and their families improve their health through lifestyle changes delivered by primary care clinics in communities in Louisiana and Tennessee.

Tirzepatide GLP-1 medication is known to improve sleep apnea for people with both obstructive sleep apnea (OSA) and obesity, but not all patients benefit equally.

People who lost significant weight while taking Ozempic, Wegovy, Mounjaro, or Saxenda had sharply lower risks of major obesity-related health problems, including sleep apnea and kidney disease. Those who gained weight instead faced higher risks — especially for heart failure — even though many patients discontinued the medications within a year.

Obesity has become one of the biggest health problems in the world, especially among older adults. As people age, extra body weight can place more pressure on the heart, joints, blood vessels, and many other parts of the body. Obesity in older adults is linked to serious health conditions such as heart disease, high blood […] The post This weight-loss drug shows strong effects in older people app…

Obesity has become one of the biggest health challenges in the world. Millions of people struggle with excess weight, and many also face serious health problems linked to obesity, including diabetes, heart disease, high blood pressure, sleep apnea, joint pain, and fatty liver disease. For many years, doctors mainly recommended diet changes, exercise, and traditional […] The post Good news about w…

Many people successfully lose weight through dieting, but keeping the weight off often becomes the hardest part of the journey. Researchers estimate that most people who lose weight eventually regain much of it within several years. This cycle of losing and regaining weight can feel frustrating and discouraging for patients trying to improve their health. […] The post This daily walking goal may …

Obesity affects hundreds of millions of people worldwide and is now considered one of the biggest public health problems of modern times. Carrying too much body fat increases the risk of many serious illnesses, including type 2 diabetes, heart disease, stroke, sleep disorders, fatty liver disease, certain cancers, and joint problems. Many people also struggle […] The post Most weight lost with po…

Obesity is becoming an increasingly serious health problem around the world, especially among older adults. As people age, carrying excess body weight can place extra strain on the heart, joints, blood vessels, lungs, and many other organs. Obesity in older age is linked to high blood pressure, heart disease, sleep problems, diabetes, reduced movement, disability, […] The post Popular weight-loss…

Weight-loss surgery has become one of the most effective treatments for severe obesity and type 2 diabetes. Many people who undergo these operations lose large amounts of weight and see major improvements in their blood sugar levels. Some patients even experience remission of type 2 diabetes, meaning their blood sugar returns to near-normal levels without […] The post Gut may hold the key to diab…

Researchers say daily exposure to cold activates brown fat and could help speed up body’s burning of calories Wearing an ice vest or taking daily cold showers could help people lose weight, according to researchers. Despite the growing popularity of cold-water swimming and freezing plunges, to date there is minimal data on the health benefits of cold exposure. But a study of 47 adults with obesit…